Semin intervent Radiol 2014; 31(01): 009-019
DOI: 10.1055/s-0033-1363838
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Imaging Management of Incidentally Detected Small Renal Masses

V. Anik Sahni
1   Division of Abdominal Imaging and Intervention, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
,
Stuart G. Silverman
1   Division of Abdominal Imaging and Intervention, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
› Author Affiliations
Further Information

Publication History

Publication Date:
20 February 2014 (online)

Abstract

Both imaging and intervention play an increasingly important role in the management of renal masses in general and renal cancer in particular. Indeed, radiologists are often the first to detect and diagnose renal cancer, and now with the burgeoning role of percutaneous ablation, they are often the treating physicians. Renal mass management begins with imaging, and although most can be diagnosed with a high degree of certainty using imaging, some remain indeterminate and require biopsy or observation, now referred to as active surveillance. Although active surveillance strategies have been employed for indeterminate renal masses that have a reasonable chance of being benign, recent data suggest that some renal cancers can undergo active surveillance safely. This article reviews the current imaging-based diagnostic evaluation of incidentally detected small renal masses, the burgeoning role of percutaneous biopsy, and how both imaging and biopsy are used to help select which patients need treatment and which can undergo active surveillance.

 
  • References

  • 1 Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61 (2) 69-90
  • 2 Tada S, Yamagishi J, Kobayashi H, Hata Y, Kobari T. The incidence of simple renal cyst by computed tomography. Clin Radiol 1983; 34 (4) 437-439
  • 3 Bosniak MA. The current radiological approach to renal cysts. Radiology 1986; 158 (1) 1-10
  • 4 Bosniak MA, Megibow AJ, Hulnick DH, Horii S, Raghavendra BN. CT diagnosis of renal angiomyolipoma: the importance of detecting small amounts of fat. AJR Am J Roentgenol 1988; 151 (3) 497-501
  • 5 Silverman SG, Israel GM, Herts BR, Richie JP. Management of the incidental renal mass. Radiology 2008; 249 (1) 16-31
  • 6 Frank I, Blute ML, Cheville JC, Lohse CM, Weaver AL, Zincke H. Solid renal tumors: an analysis of pathological features related to tumor size. J Urol 2003; 170 (6, Pt 1) 2217-2220
  • 7 Rendon RA, Stanietzky N, Panzarella T , et al. The natural history of small renal masses. J Urol 2000; 164 (4) 1143-1147
  • 8 Beland MD, Mayo-Smith WW, Dupuy DE, Cronan JJ, DeLellis RA. Diagnostic yield of 58 consecutive imaging-guided biopsies of solid renal masses: should we biopsy all that are indeterminate?. AJR Am J Roentgenol 2007; 188 (3) 792-797
  • 9 Edge SE, Byrd DR, Compton CC , et al , eds. AJCC Cancer Staging Manual. New York, NY: Springer; 2009
  • 10 Israel GM, Bosniak MA. Follow-up CT of moderately complex cystic lesions of the kidney (Bosniak category IIF). AJR Am J Roentgenol 2003; 181 (3) 627-633
  • 11 Cloix P, Martin X, Pangaud C , et al. Surgical management of complex renal cysts: a series of 32 cases. J Urol 1996; 156 (1) 28-30
  • 12 Aronson S, Frazier HA, Baluch JD, Hartman DS, Christenson PJ. Cystic renal masses: usefulness of the Bosniak classification. Urol Radiol 1991; 13 (2) 83-90
  • 13 Bosniak MA, Rofsky NM. Problems in the detection and characterization of small renal masses. Radiology 1996; 198 (3) 638-641
  • 14 Smith AD, Remer EM, Cox KL , et al. Bosniak category IIF and III cystic renal lesions: outcomes and associations. Radiology 2012; 262 (1) 152-160
  • 15 Curry NS, Cochran ST, Bissada NK. Cystic renal masses: accurate Bosniak classification requires adequate renal CT. AJR Am J Roentgenol 2000; 175 (2) 339-342
  • 16 Lang EK, Macchia RJ, Gayle B , et al. CT-guided biopsy of indeterminate renal cystic masses (Bosniak 3 and 2F): accuracy and impact on clinical management. Eur Radiol 2002; 12 (10) 2518-2524
  • 17 Harisinghani MG, Maher MM, Gervais DA , et al. Incidence of malignancy in complex cystic renal masses (Bosniak category III): should imaging-guided biopsy precede surgery?. AJR Am J Roentgenol 2003; 180 (3) 755-758
  • 18 Warshauer DM, McCarthy SM, Street L , et al. Detection of renal masses: sensitivities and specificities of excretory urography/linear tomography, US, and CT. Radiology 1988; 169 (2) 363-365
  • 19 Paudice N, Zanazzi M, Agostini S , et al. Contrast-enhanced ultrasound assessment of complex cystic lesions in renal transplant recipients with acquired cystic kidney disease: preliminary experience. Transplant Proc 2012; 44 (7) 1928-1929
  • 20 O'Connor SD, Pickhardt PJ, Kim DH, Oliva MR, Silverman SG. Incidental finding of renal masses at unenhanced CT: prevalence and analysis of features for guiding management. AJR Am J Roentgenol 2011; 197 (1) 139-145
  • 21 Pooler BD, Pickhardt PJ, O'Connor SD, Bruce RJ, Patel SR, Nakada SY. Renal cell carcinoma: attenuation values on unenhanced CT. AJR Am J Roentgenol 2012; 198 (5) 1115-1120
  • 22 O'Connor SD, Silverman SG, Ip IK, Maehara CK, Khorasani R. Simple cyst-appearing renal masses at unenhanced CT: can they presumed to be benign?. Radiology 2013; 269 (3) 793-800
  • 23 Jonisch AI, Rubinowitz A, Mutalik P, Israel G. Can high attenuation renal cysts be differentiated from renal cell carcinoma at unenhanced computed tomography?. Radiology 2007; 243: 445-450
  • 24 Maki DD, Birnbaum BA, Chakraborty DP, Jacobs JE, Carvalho BM, Herman GT. Renal cyst pseudoenhancement: beam-hardening effects on CT numbers. Radiology 1999; 213 (2) 468-472
  • 25 Kataria B, Smedby O. Patient dose and image quality in low-dose abdominal CT: a comparison between iterative reconstruction and filtered back projection. Acta Radiol 2013; ; [Epub ahead of print]
  • 26 Yeh BM, Shepherd JA, Wang ZJ, Teh HS, Hartman RP, Prevrhal S. Dual-energy and low-kVp CT in the abdomen. AJR Am J Roentgenol 2009; 193 (1) 47-54
  • 27 Shinagare AB, Sahni VA, Sadow CA, Erturk SM, Silverman SG. Feasibility of low-tube-voltage excretory phase images during CT urography: assessment using a dual-energy CT scanner. AJR Am J Roentgenol 2011; 197 (5) 1146-1151
  • 28 Leschka S, Stolzmann P, Baumüller S , et al. Performance of dual-energy CT with tin filter technology for the discrimination of renal cysts and enhancing masses. Acad Radiol 2010; 17 (4) 526-534
  • 29 Sahni VA, Shinagare AB, Silverman SG. Virtual unenhanced CT images acquired from dual-energy CT urography: accuracy of attenuation values and variation with contrast material phase. Clin Radiol 2013; 68 (3) 264-271
  • 30 Israel GM, Hindman N, Bosniak MA. Evaluation of cystic renal masses: comparison of CT and MR imaging by using the Bosniak classification system. Radiology 2004; 231 (2) 365-371
  • 31 Miller MA, Brown JJ. Renal cysts and cystic neoplasms. Magn Reson Imaging Clin N Am 1997; 5 (1) 49-66
  • 32 Israel GM, Bosniak MA. MR imaging of cystic renal masses. Magn Reson Imaging Clin N Am 2004; 12 (3) 403-412 , v
  • 33 Sandrasegaran K, Sundaram CP, Ramaswamy R , et al. Usefulness of diffusion-weighted imaging in the evaluation of renal masses. AJR Am J Roentgenol 2010; 194 (2) 438-445
  • 34 Inci E, Hocaoglu E, Aydin S, Cimilli T. Diffusion-weighted magnetic resonance imaging in evaluation of primary solid and cystic renal masses using the Bosniak classification. Eur J Radiol 2012; 81 (5) 815-820
  • 35 Taouli B, Thakur RK, Mannelli L , et al. Renal lesions: characterization with diffusion-weighted imaging versus contrast-enhanced MR imaging. Radiology 2009; 251 (2) 398-407
  • 36 Grobner T. Gadolinium—a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?. Nephrol Dial Transplant 2006; 21 (4) 1104-1108
  • 37 Cowper SE, Robin HS, Steinberg SM, Su LD, Gupta S, LeBoit PE. Scleromyxoedema-like cutaneous diseases in renal-dialysis patients. Lancet 2000; 356 (9234) 1000-1001
  • 38 American College of Radiology. ACR Manual on Contrast Media—Version 9. Reston, VA; 2013
  • 39 Silverman SG, Gan YU, Mortele KJ, Tuncali K, Cibas ES. Renal masses in the adult patient: the role of percutaneous biopsy. Radiology 2006; 240 (1) 6-22
  • 40 Sahni VA, Silverman SG. Biopsy of renal masses: when and why. Cancer Imaging 2009; 9: 44-55
  • 41 Rybicki FJ, Shu KM, Cibas ES, Fielding JR, vanSonnenberg E, Silverman SG. Percutaneous biopsy of renal masses: sensitivity and negative predictive value stratified by clinical setting and size of masses. AJR Am J Roentgenol 2003; 180 (5) 1281-1287
  • 42 Renshaw AA, Granter SR, Cibas ES. Fine-needle aspiration of the adult kidney. Cancer 1997; 81 (2) 71-88
  • 43 Sahni VA, Mortele KJ, Glickman J, Silverman SG. Mixed epithelial and stromal tumour of the kidney: imaging features. BJU Int 2010; 105 (7) 932-939
  • 44 Lane BR, Campbell SC, Remer EM , et al. Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney: clinical, radiographic, and pathologic characteristics. Urology 2008; 71 (6) 1142-1148
  • 45 Rosales JC, Haramis G, Moreno J , et al. Active surveillance for renal cortical neoplasms. J Urol 2010; 183 (5) 1698-1702
  • 46 Kawashima A, Goldman SM, Sandler CM. The indeterminate renal mass. Radiol Clin North Am 1996; 34 (5) 997-1015
  • 47 Sugimoto S, Tsujimoto F, Kato Y , et al. Sonographic patterns of renal cell carcinoma with emphasis on relation to tumor size. J Clin Ultrasound 1984; 12 (5) 247-250
  • 48 Habboub HK, Abu-Yousef MM, Williams RD, See WA, Schweiger GD. Accuracy of color Doppler sonography in assessing venous thrombus extension in renal cell carcinoma. AJR Am J Roentgenol 1997; 168 (1) 267-271
  • 49 Hartman DS, Goldman SM, Friedman AC, Davis Jr CJ, Madewell JE, Sherman JL. Angiomyolipoma: ultrasonic-pathologic correlation. Radiology 1981; 139 (2) 451-458
  • 50 Siegel CL, Middleton WD, Teefey SA, McClennan BL. Angiomyolipoma and renal cell carcinoma: US differentiation. Radiology 1996; 198 (3) 789-793
  • 51 Jinzaki M, Ohkuma K, Tanimoto A , et al. Small solid renal lesions: usefulness of power Doppler US. Radiology 1998; 209 (2) 543-550
  • 52 Bosniak MA, Megibow AJ, Hulnick DH, Horii S, Raghavendra BN. CT diagnosis of renal angiomyolipoma: the importance of detecting small amounts of fat. AJR Am J Roentgenol 1988; 151 (3) 497-501
  • 53 Wasser EJ, Shyn PB, Riveros-Angel M, Sadow CA, Steele GS, Silverman SG. Renal cell carcinoma containing abundant non-calcified fat. Abdom Imaging 2013; 38 (3) 598-602
  • 54 Strotzer M, Lehner KB, Becker K. Detection of fat in a renal cell carcinoma mimicking angiomyolipoma. Radiology 1993; 188 (2) 427-428
  • 55 Schuster TG, Ferguson MR, Baker DE, Schalenbrand JD, Solomon MH. Papillary renal cell carcinoma containing fat without calcification mimicking angiomyolipoma on CT. AJR Am J Roentgenol 2004; 183 (5) 1402-1404
  • 56 Silverman SG, Mortele KJ, Tuncali K, Jinzaki M, Cibas ES. Hyperattenuating renal masses: etiologies, pathogenesis, and imaging evaluation. Radiographics 2007; 27 (4) 1131-1143
  • 57 Jinzaki M, Tanimoto A, Narimatsu Y , et al. Angiomyolipoma: imaging findings in lesions with minimal fat. Radiology 1997; 205 (2) 497-502
  • 58 Zhang YY, Luo S, Liu Y, Xu RT. Angiomyolipoma with minimal fat: differentiation from papillary renal cell carcinoma by helical CT. Clin Radiol 2013; 68 (4) 365-370
  • 59 Pierorazio PM, Hyams ES, Tsai S , et al. Multiphasic enhancement patterns of small renal masses (≤4 cm) on preoperative computed tomography: utility for distinguishing subtypes of renal cell carcinoma, angiomyolipoma, and oncocytoma. Urology 2013; 81 (6) 1265-1271
  • 60 Israel GM, Hindman N, Hecht E, Krinsky G. The use of opposed-phase chemical shift MRI in the diagnosis of renal angiomyolipomas. AJR Am J Roentgenol 2005; 184 (6) 1868-1872
  • 61 Outwater EK, Bhatia M, Siegelman ES, Burke MA, Mitchell DG. Lipid in renal clear cell carcinoma: detection on opposed-phase gradient-echo MR images. Radiology 1997; 205 (1) 103-107
  • 62 Shinmoto H, Yuasa Y, Tanimoto A , et al. Small renal cell carcinoma: MRI with pathologic correlation. J Magn Reson Imaging 1998; 8 (3) 690-694
  • 63 Oliva MR, Glickman JN, Zou KH , et al. Renal cell carcinoma: t1 and t2 signal intensity characteristics of papillary and clear cell types correlated with pathology. AJR Am J Roentgenol 2009; 192 (6) 1524-1530
  • 64 Tikkakoski T, Päivänsalo M, Alanen A , et al. Radiologic findings in renal oncocytoma. Acta Radiol 1991; 32 (5) 363-367
  • 65 Ambos MA, Bosniak MA, Valensi QJ, Madayag MA, Lefleur RS. Angiographic patterns in renal oncocytomas. Radiology 1978; 129 (3) 615-622
  • 66 Davidson AJ, Hayes WS, Hartman DS, McCarthy WF, Davis Jr CJ. Renal oncocytoma and carcinoma: failure of differentiation with CT. Radiology 1993; 186 (3) 693-696
  • 67 Kim JI, Cho JY, Moon KC, Lee HJ, Kim SH. Segmental enhancement inversion at biphasic multidetector CT: characteristic finding of small renal oncocytoma. Radiology 2009; 252 (2) 441-448
  • 68 Woo S, Cho JY, Kim SH , et al. Segmental enhancement inversion of small renal oncocytoma: differences in prevalence according to tumor size. AJR Am J Roentgenol 2013; 200 (5) 1054-1059
  • 69 Zhang J, Tehrani YM, Wang L, Ishill NM, Schwartz LH, Hricak H. Renal masses: characterization with diffusion-weighted MR imaging—a preliminary experience. Radiology 2008; 247 (2) 458-464
  • 70 Wang H, Cheng L, Zhang X , et al. Renal cell carcinoma: diffusion-weighted MR imaging for subtype differentiation at 3.0 T. Radiology 2010; 257 (1) 135-143
  • 71 Chowdhury S, Choueiri TK. Recent advances in the systemic treatment of metastatic papillary renal cancer. Expert Rev Anticancer Ther 2009; 9 (3) 373-379
  • 72 Escudier B, Eisen T, Stadler WM , et al; TARGET Study Group. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007; 356 (2) 125-134
  • 73 Liu J, Fanning CV. Can renal oncocytomas be distinguished from renal cell carcinoma on fine-needle aspiration specimens? A study of conventional smears in conjunction with ancillary studies. Cancer 2001; 93 (6) 390-397
  • 74 Zhou M, Roma A, Magi-Galluzzi C. The usefulness of immunohistochemical markers in the differential diagnosis of renal neoplasms. Clin Lab Med 2005; 25 (2) 247-257
  • 75 Lebret T, Poulain JE, Molinie V , et al. Percutaneous core biopsy for renal masses: indications, accuracy and results. J Urol 2007; 178 (4, Pt 1) 1184-1188 , discussion 1188
  • 76 Leveridge MJ, Finelli A, Kachura JR , et al. Outcomes of small renal mass needle core biopsy, nondiagnostic percutaneous biopsy, and the role of repeat biopsy. Eur Urol 2011; 60 (3) 578-584
  • 77 Shannon BA, Cohen RJ, de Bruto H, Davies RJ. The value of preoperative needle core biopsy for diagnosing benign lesions among small, incidentally detected renal masses. J Urol 2008; 180 (4) 1257-1261 , discussion 1261
  • 78 Sánchez-Ortiz RF, Madsen LT, Bermejo CE , et al. A renal mass in the setting of a nonrenal malignancy: when is a renal tumor biopsy appropriate?. Cancer 2004; 101 (10) 2195-2201
  • 79 Silverman SG, Tuncali K, vanSonnenberg E , et al. Renal tumors: MR imaging-guided percutaneous cryotherapy—initial experience in 23 patients. Radiology 2005; 236 (2) 716-724
  • 80 Choyke PL, Glenn GM, Walther MM, Zbar B, Linehan WM. Hereditary renal cancers. Radiology 2003; 226 (1) 33-46
  • 81 Tickoo SK, Reuter VE, Amin MB , et al. Renal oncocytosis: a morphologic study of fourteen cases. Am J Surg Pathol 1999; 23 (9) 1094-1101
  • 82 Renshaw AA, Lee KR, Madge R, Granter SR. Accuracy of fine needle aspiration in distinguishing subtypes of renal cell carcinoma. Acta Cytol 1997; 41 (4) 987-994
  • 83 Halverson SJ, Kunju LP, Bhalla R , et al. Accuracy of determining small renal mass management with risk stratified biopsies: confirmation by final pathology. J Urol 2013; 189 (2) 441-446
  • 84 Gayed BA, Youssef RF, Bagrodia A , et al. Prognostic role of cell cycle and proliferative biomarkers in patients with clear cell renal cell carcinoma. J Urol 2013; 190 (5) 1662-1667
  • 85 Campbell SC, Novick AC, Belldegrun A , et al; Practice Guidelines Committee of the American Urological Association. Guideline for management of the clinical T1 renal mass. J Urol 2009; 182 (4) 1271-1279
  • 86 Smaldone MC, Kutikov A, Egleston BL , et al. Small renal masses progressing to metastases under active surveillance: a systematic review and pooled analysis. Cancer 2012; 118 (4) 997-1006
  • 87 Kunkle DA, Egleston BL, Uzzo RG. Excise, ablate or observe: the small renal mass dilemma—a meta-analysis and review. J Urol 2008; 179 (4) 1227-1233 , discussion 1233–1234
  • 88 Hollingsworth JM, Miller DC, Daignault S, Hollenbeck BK. Rising incidence of small renal masses: a need to reassess treatment effect. J Natl Cancer Inst 2006; 98 (18) 1331-1334
  • 89 Patel N, Cranston D, Akhtar MZ , et al. Active surveillance of small renal masses offers short-term oncological efficacy equivalent to radical and partial nephrectomy. BJU Int 2012; 110 (9) 1270-1275
  • 90 Donat SM, Diaz M, Bishoff JT , et al. Follow-up for clinically localized renal neoplasms: AUA guideline. J Urol 2013; 190 (2) 407-416
  • 91 Friberg S, Mattson S. On the growth rates of human malignant tumors: implications for medical decision making. J Surg Oncol 1997; 65 (4) 284-297
  • 92 Mues AC, Landman J. Small renal masses: current concepts regarding the natural history and reflections on the American Urological Association guidelines. Curr Opin Urol 2010; 20 (2) 105-110