Handchir Mikrochir Plast Chir 2014; 46(04): 248-255
DOI: 10.1055/s-0034-1385851
Consensus Statement
© Georg Thieme Verlag KG Stuttgart · New York

Rekonstruktion der vaskulär kompromittierten unteren Extremität – Bericht des Consensus-Workshops im Rahmen der 35. Jahrestagung der DAM 2013 in Deidesheim

Reconstruction of the Vascular Compromised Lower Extremity – Report of the Consensus Workshop at the 35. Meeting of the DAM (Deutschsprachige Gemeinschaft für Mikrochirurgie der peripheren Nerven und Gefäße) 2013 in Deidesheim
A. Daigeler
1   Klinik für Plastische Chirurgie und Schwerbrandverletzte, Handchirurgiezentrum Operatives Referenzzentrum für Gliedmaßentumoren, BG-Universitätsklinikum Bergmannsheil, Ruhr-Universität Bochum, Bochum
,
U. Kneser
2   Klinik für Hand-, Plastische und Rekonstruktive Chirurgie, Schwerbrandverletztenzentrum, BG-Unfallklinik Ludwigshafen, Klinik für Plastische Chirurgie und Handchirurgie an der Rupprecht-Karls-Universität Heidelberg, Ludwigshafen
,
H. Fansa
3   Heitmann und Fansa – Ästhetisch Plastische Chirurgie, Gemeinschaftspraxis für Plastisch Ästhetische Chirurgie, München
,
T. Riester
4   Chirurgische Klinik, Gefäßchirurgie, Universitätsklinikum Mannheim, ­Universitätsmedizin Mannheim, Mannheim,
,
M. Uder
5   Radiologisches Institut, Universitätsklinikum Erlangen, Erlangen
,
R. E. Horch
6   Universitätsklinikum Erlangen, Plastische und Handchirurgie, Erlangen
› Author Affiliations
Further Information

Publication History

eingereicht 31 March 2014

akzeptiert 02 July 2014

Publication Date:
27 August 2014 (online)

Zusammenfassung

Einleitung: Nachdem die mikrochirurgische Rekonstruktion bei Patienten mit kritischen Perfusionsstörungen und arterieller Verschlusskrankheit in mehreren Zentren zunehmend durchgeführt wird, besteht die Notwendigkeit einer Standardisierung des interdisziplinären Diagnostik- und Therapieregimes bei diesen kritisch kranken Patienten. Im Rahmen eines Consensus-Workshops zur Rekonstruktion der vaskulär kompromittierten unteren Extremität anlässlich der 35. Jahrestagung der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der peripheren Nerven und Gefäße 2013 in Deidesheim wurden durch Mitglieder der DAM zusammen mit Gefäßchirurgen und interventionellen Radiologen die Diagnose- und Therapiemöglichkeiten bei diesen Fragestellungen eruiert, interdisziplinär diskutiert und wesentliche Empfehlungen festgehalten.

Methode: Anhand einer Literaturrecherche und der Ergebnisse der Expertendiskussion werden die Therapiemöglichkeiten und -grenzen aufgezeigt und Hinweise zur erfolgreichen Rekonstruktion durch Kooperation gegeben.

Ergebnisse: Durch die interdisziplinäre Zusammenarbeit können Extremitäten erhalten werden und dadurch nicht nur die Lebensqualität verbessert, sondern – wie sich anhand von Literaturdaten zeigt – auch die Lebensdauer von schwer gefäßerkrankten Patienten verlängert werden. Es wurden unterschiedliche Konzepte für diese Patientengruppe entwickelt, bei denen ein- oder mehrzeitige rekonstruktive Eingriffe mit gefäßerweiternden Verfahren, alleine oder in Kombination mit unterschiedlichen Konfigura­tionen von autologen Bypasses zur differenzierten Anwendung kommen. Freie Lappenplastiken erhalten durch die Revaskularisierung im Sinne eines „nutrient flap“ Anschlussmöglichkeiten und können zu einer verbesserten Perfusion der unteren Extremität beitragen. Die erhöhten perioperativen Risiken erscheinen bei sorgfältiger präoperativer Evaluation und adäquater Indikationsstellung für die Patienten vertretbar.

Diskussion: Der schlechte Allgemeinzustand der Patienten ­erfordert eine entsprechende interdisziplinäre präoperative Planung, die auf den Einzelfall abgestimmt werden muss. Der ­Anschluss von freien Lappen auf einen Bypass oder an eine rekanalisierte Gefäßachse ermöglicht nicht nur die Deckung von großen Defekten, er stellt auch durch die Erhöhung des Blutflusses im Bypass einen hämodynamischen Vorteil dar. Dies ist auf das zusätzliche Gefäßbett zurückzuführen, das mit dem freien Lappen transplantiert wird. Der Erhalt der Mobilität bietet für dieses Patientengut wesentliche Vorteile, wobei stets der initial weniger belastende Eingriff der Amputation auch in Betracht gezogen werden muss.

Abstract

Introduction: As microsurgical reconstruction is now being increasingly performed on patients with critical peripheral perfusion and/or arterial occlusive disease in numerous centres, there is a need for standardisation of interdisciplinary diagnostic approach and treatment regimens in such critically ill patients. In a consensus workshop on reconstruction of the vascular compromised lower extremity during the 35th Annual Meeting of the German working group microsurgery of the peripheral nerves and vessels (DAM) in 2013 in Deidesheim, DAM members together with vascular surgeons and interventional radiologists attempted to establish interdisciplinarily routine pathways for diagnosis and therapy and to consolidate key recommendations for treatment.

Methods: By reviewing the literature and considering the results of the expert meetings, options and limits of therapy were illustrated and recommendations for successful cooperative treatment formulated.

Results: By means of interdisciplinary cooperation, limbs can be salvaged and the quality of live as well as survival of patients with severe peripheral vascular disease improved. Different techniques including angioplasty, bypass surgery and microsurgical free flaps can be applied and individualised concepts allow extremity salvage even in patients with severely compromised limbs. Revascularisation provides the possibility of free flap transfer while the risk for the patients is moderate.

Discussion: The poor general condition of the patient requires a sufficient interdisciplinary preoperative planning. By means of interdisciplinary cooperation, the limbs can be salvaged. This not only improves the quality of life but also increases the survival time of patients with occlusive vascular disease. Different concepts for this group of patients have been developed. Surgical treatment with a distal bypass or recanalisation and free flap not only allow for the coverage of large defects, but also represent a haemodynamic advantage by increased blood flow in the bypass. This is attributed to the additional vascular bed that is transplanted with the free flap. Limb salvage means relevant improvement, however, the initially less demanding procedure of amputation must always be considered.

 
  • Literatur

  • 1 Kolbenschlag J, Hellmich S, Germann G et al. Free tissue transfer in patients with severe peripheral arterial disease: functional outcome in reconstruction of chronic lower extremity defects. Journal of reconstructive microsurgery 2013; 29: 607-614
  • 2 Keagy BA, Schwartz JA, Kotb M et al. Lower extremity amputation: the control series. Journal of vascular surgery 1986; 4: 321-326
  • 3 Luther M. Surgical treatment for chronic critical leg ischaemia: a 5 year follow-up of socioeconomic outcome. European journal of vascular and endovascular surgery: the official journal of the European Society for Vascular Surgery 1997; 13: 452-459
  • 4 Luther M. Surgical treatment of chronic critical leg ischaemia. A five-year follow-up of survival, mobility, and treatment level. The European journal of surgery=Acta chirurgica 1998; 164: 35-43
  • 5 Aust MC, Spies M, Guggenheim M et al. Lower limb revascularisation preceding surgical wound coverage – an interdisciplinary algorithm for chronic wound closure. Journal of plastic, reconstructive & aesthetic surgery: JPRAS 2008; 61: 925-933
  • 6 Fitzgerald O’Connor EJ, Vesely M, Holt PJ et al. A systematic review of free tissue transfer in the management of non-traumatic lower extremity wounds in patients with diabetes. European journal of vascular and endovascular surgery: the official journal of the European Society for Vascular Surgery 2011; 41: 391-399
  • 7 Mackey WC, McCullough JL, Conlon TP et al. The costs of surgery for limb-threatening ischemia. Surgery 1986; 99: 26-35
  • 8 Graziani L, Silvestro A, Bertone V et al. Vascular involvement in diabetic subjects with ischemic foot ulcer: a new morphologic categorization of disease severity. European journal of vascular and endovascular surgery: the official journal of the European Society for Vascular Surgery 2007; 33: 453-460
  • 9 Brillu C, Picquet J, Villapadierna F et al. Percutaneous transluminal angioplasty for management of critical ischemia in arteries below the knee. Annals of vascular surgery 2001; 15: 175-181
  • 10 Romiti M, Albers M, Brochado-Neto FC et al. Meta-analysis of infrapopliteal angioplasty for chronic critical limb ischemia. Journal of vascular surgery 2008; 47: 975-981
  • 11 Adam DJ, Beard JD, Cleveland T et al. Bypass versus angioplasty in severe ischaemia of the leg (BASIL): multicentre, randomised controlled trial. Lancet 2005; 366: 1925-1934
  • 12 Lipsky BA, Berendt AR, Deery HG et al. Diagnosis and treatment of diabetic foot infections. Plastic and reconstructive surgery 2006; 117: 212 S-238 S
  • 13 Lipsky BA, Berendt AR, Deery HG et al. Diagnosis and treatment of diabetic foot infections. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America 2004; 39: 885-910
  • 14 Schirmer S, Ritter RG, Rice A et al. Preventing lower limb amputations in patients suffering from diabetic foot syndrome and peripheral vascular disease – opportunities and limitations. Handchirurgie, Mikrochirurgie, plastische Chirurgie: Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie: Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefäße 2011; 43: 338-344
  • 15 Schirmer S, Ritter RG, Fansa H. Vascular surgery, microsurgery and supramicrosurgery for treatment of chronic diabetic foot ulcers to prevent amputations. PloS one 2013; 8: e74704
  • 16 Rao N, Ziran BH, Lipsky BA. Treating osteomyelitis: antibiotics and surgery. Plastic and reconstructive surgery 2011; 127 (Suppl. 01) 177 S-187 S
  • 17 Lorenzetti F, Tukiainen E, Alback A et al. Blood flow in a pedal bypass combined with a free muscle flap. European journal of vascular and endovascular surgery: the official journal of the European Society for Vascular Surgery 2001; 22: 161-164
  • 18 Malikov S, Magnan PE, Casanova D et al. Bypass flap reconstruction, a novel technique for distal revascularization: outcome of first 10 clinical cases. Annals of vascular surgery 2009; 23: 745-752
  • 19 Illig KA, Moran S, Serletti J et al. Combined free tissue transfer and infrainguinal bypass graft: an alternative to major amputation in selected patients. Journal of vascular surgery 2001; 33: 17-23
  • 20 Selber JC, Garvey PB, Clemens MW et al. A prospective study of transit-time flow volume measurement for intraoperative evaluation and optimization of free flaps. Plastic and reconstructive surgery 2013; 131: 270-281
  • 21 Malikov S, Casanova D, Magnan PE et al. Anatomical bases of the bypass-flap: study of the thoracodorsal axis. Surgical and radiologic anatomy: SRA 2005; 27: 86-93
  • 22 Cornelius JF, George B, Kolb F. Combined use of a radial fore arm free flap for extra-intracranial bypass and for antero-lateral skull base reconstruction – a new technique and review of literature. Acta neurochirurgica 2006; 148: 427-434
  • 23 Horch RE, Horbach T, Lang W. The nutrient omentum free flap: revascularization with vein bypasses and greater omentum flap in severe arterial ulcers. Journal of vascular surgery 2007; 45: 837-840
  • 24 Horch RE, Dragu A, Lang W et al. Coverage of exposed bones and joints in critically ill patients: lower extremity salvage with topical negative pressure therapy. Journal of cutaneous medicine and surgery 2008; 12: 223-229
  • 25 Tukiainen E, Kallio M, Lepantalo M. Advanced leg salvage of the critically ischemic leg with major tissue loss by vascular and plastic surgeon teamwork: Long-term outcome. Annals of surgery. 2006; 244: 649-957 discussion 957-948
  • 26 Tukiainen E, Biancari F, Lepantalo M. Lower limb revascularization and free flap transfer for major ischemic tissue loss. World journal of surgery 2000; 24: 1531-1536
  • 27 Kristensen MT, Holm G, Kirketerp-Moller K et al. Very low survival rates after non-traumatic lower limb amputation in a consecutive series: what to do?. Interactive cardiovascular and thoracic surgery 2012; 14: 543-547
  • 28 Davies MG. Criticial limb ischemia: epidemiology. Methodist DeBakey cardiovascular journal 2012; 8: 10-14
  • 29 Moran SL, Salgado CJ, Serletti JM. Free tissue transfer in patients with renal disease. Plastic and reconstructive surgery 2004; 113: 2006-2011
  • 30 Briggs SE, Banis Jr JC, Kaebnick H et al. Distal revascularization and microvascular free tissue transfer: an alternative to amputation in ischemic lesions of the lower extremity. Journal of vascular surgery 1985; 2: 806-811
  • 31 Lepantalo M, Tukiainen E. Combined vascular reconstruction and microvascular muscle flap transfer for salvage of ischaemic legs with major tissue loss and wound complications. European journal of vascular and endovascular surgery: the official journal of the European Society for Vascular Surgery 1996; 12: 65-69
  • 32 Serletti JM, Hurwitz SR, Jones JA et al. Extension of limb salvage by combined vascular reconstruction and adjunctive free-tissue transfer. Journal of vascular surgery. 1993; 18: 972-978 discussion 978–980
  • 33 Ciresi KF, Anthony JP, Hoffman WY et al. Limb salvage and wound coverage in patients with large ischemic ulcers: a multidisciplinary approach with revascularization and free tissue transfer. Journal of vascular surgery. 1993; 18: 648-653 discussion 653-645
  • 34 Czerny M, Trubel W, Zimpfer D et al. Limb-salvage by femoro-distal bypass and free muscle flap transfer. European journal of vascular and endovascular surgery: the official journal of the European Society for Vascular Surgery 2004; 27: 635-639
  • 35 Eweida AM, Lang W, Schmitz M et al. Salvage of a free radial forearm flap by creation of an arteriovenous fistula at the distal arterial pedicle. Microsurgery 2013; 33: 391-395
  • 36 Fischer S, Klinkenberg M, Behr B et al. Comparison of donor-site morbidity and satisfaction between anterolateral thigh and parascapular free flaps in the same patient. Journal of reconstructive microsurgery 2013; 29: 537-544
  • 37 Bergman BA, Zamboni WA, Brown RE. Microvascular anastomosis of a rectus abdominis free flap into a prosthetic vascular bypass graft. Journal of reconstructive microsurgery 1992; 8: 9-12
  • 38 Kasabian AK, Glat PM, Eidelman Y et al. Limb salvage with microvascular free flap reconstruction using simultaneous polytetrafluoroethylene graft for inflow. Annals of plastic surgery 1995; 35: 310-315
  • 39 Malikov S, Magnan PE, Champsaur P et al. Subscapular artery Y-shaped flow-through muscle flap: a novel one-stage limb salvage procedure. Journal of vascular surgery 2008; 48: 159-166
  • 40 Malikov S, Casanova D, Champsaur P et al. The bypass flap: an innovative technique of distal revascularization – anatomical study and clinical application. Annals of vascular surgery 2004; 18: 535-543
  • 41 Partecke BD, Buck-Gramcko D. Free forearm flap as a possibility for simultaneous reconstruction of damaged peripheral circulation and skin. Handchirurgie, Mikrochirurgie, plastische Chirurgie: Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie: Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefäße 1984; 16: 3-6
  • 42 Tukiainen E, Laurila K, Kallio M et al. Internal arteriovenous fistula within a radial forearm flap – a novel technique to increase femorodistal bypass graft flow to the diabetic foot and flap covering ischaemic tissue loss. European journal of vascular and endovascular surgery: the official journal of the European Society for Vascular Surgery 2006; 31: 423-430
  • 43 Sunar H, Aygit CA, Afsar Y et al. Arterial and venous reconstruction for free tissue transfer in diabetic ischemic foot ulcers. European journal of vascular and endovascular surgery: the official journal of the European Society for Vascular Surgery 2004; 27: 210-215
  • 44 Sonntag BV, Murphy Jr RX, Chernofsky MA et al. Microvascular steal phenomenon in lower extremity reconstruction. Annals of plastic surgery. 1995; 34: 336-339 discussion 339–340
  • 45 Salgado CJ, Smith A, Kim S et al. Effects of late loss of arterial inflow on free flap survival. Journal of reconstructive microsurgery 2002; 18: 579-584
  • 46 Mimoun M, Hilligot P, Baux S. The nutrient flap: a new concept of the role of the flap and application to the salvage of arteriosclerotic lower limbs. Plastic and reconstructive surgery 1989; 84: 458-467
  • 47 Walgenbach KJ, Voigt M, Horch R et al. Surgically-induced angiogenesis as basic principle in treatment ov hypovascularized wounds – the nutritive flap. Langenbecks Archiv für Chirurgie Supplement Kongressband Deutsche Gesellschaft für Chirurgie Kongress 1998; 115: 1186-1188
  • 48 Cavadas PC. Arteriovenous vascular loops in free flap reconstruction of the extremities. Plastic and reconstructive surgery 2008; 121: 514-520
  • 49 Igari K, Kudo T, Toyofuku T et al. Combined arterial reconstruction and free tissue transfer for patients with critical limb ischemia. Annals of vascular diseases 2013; 6: 706-710
  • 50 Kneser U, Arkudas A, Beier JP et al. Extended skin and soft tissue defects after vascular wounds: plastic surgical concepts. Zentralblatt für Chirurgie 2013; 138: 536-542