Clin Colon Rectal Surg 2015; 28(02): 065-069
DOI: 10.1055/s-0035-1547333
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Persistent and Recurrent Clostridium difficile Colitis

Shola A. Cole
1   Section of Colon and Rectal Surgery, MedStar Washington Hospital Center, Washington, District of Columbia
,
Thomas J. Stahl
2   Interim Chair, Department of Surgery, MedStar Washington Hospital Center; Regional Director, MedStar Colorectal Surgery Program, Washington, District of Columbia
› Author Affiliations
Further Information

Publication History

Publication Date:
25 May 2015 (online)

Abstract

Clostridium difficile infection (CDI) is the most frequent cause of nosocomial diarrhea. It has become a significant dilemma in the treatment of patients, and causes increasing morbidity that, in extreme cases, may result in death. Persistent and recurrent disease hamper attempts at eradication of this infection. Escalating levels of treatment and novel therapeutics are being utilized and developed to treat CDI. Further trials are warranted to definitively determine what protocols can be used to treat persistent and recurrent disease.