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Am J Perinatol 2015; 32(11): 1038-1044
DOI: 10.1055/s-0035-1548729
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Short-Term Outcomes and Medical and Surgical Interventions in Infants with Congenital Diaphragmatic Hernia

Theresa R. Grover
1   Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, Colorado
,
Karna Murthy   *
2   Ann and Robert H. Lurie Children's Hospital and Feinberg School of Medicine, Northwestern University, Chicago, Illinois
,
Beverly Brozanski
3   Children's Hospital of Pittsburgh and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
,
Jason Gien
1   Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, Colorado
,
Natalie Rintoul
4   Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
,
Sarah Keene
5   Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, Georgia
,
Tasnim Najaf
6   Washington University, St. Louis, Missouri
,
Louis Chicoine
7   Nationwide Children's Hospital, Columbus, Ohio
,
Nicolas Porta
2   Ann and Robert H. Lurie Children's Hospital and Feinberg School of Medicine, Northwestern University, Chicago, Illinois
,
Isabella Zaniletti
8   Children's Hospital Association, Overland Park, Kansas
,
Eugenia K. Pallotto   *
9   Children's Mercy Hospital and University of Missouri, Kansas City, Missouri
,
and the Children's Hospitals Neonatal Consortium › Author Affiliations
Further Information

Publication History

14 October 2014

20 January 2015

Publication Date:
31 March 2015 (online)

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Abstract

Objective The aim of this study is to characterize medical and surgical therapies and short-term outcomes in infants with congenital diaphragmatic hernia (CDH).

Study Design Retrospective analysis of CDH infants admitted to 27 children's hospitals submitting data to Children's Hospital Neonatal Database (CHND) from 2010 to 2013, stratified by gestational age, birth weight, and survival.

Results A total of 572 infants were identified, 508 (89%) born ≥ 34 weeks' gestation and ≥ 2 kg. More mature infants had higher APGAR scores, shorter duration of mechanical ventilation, and were more likely to receive extracorporeal membrane oxygenation (ECMO). Overall, mortality for the cohort was 29%, with mortality lower in infants born ≥ 34 weeks' gestation and ≥ 2 kg (26 vs. 50%, p < 0.01). Nonsurvivors were more likely to receive treatment with high-frequency oscillatory ventilation (HFOV), vasopressors, pulmonary vasodilators, and ECMO, and to have associated major congenital anomalies than survivors. In hospital morbidity and complications were relatively uncommon among survivors.

Conclusion Infants with CDH have a high risk of morbidity and mortality, and for preterm infants with CDH those risks are amplified. Patterns of respiratory and circulatory support appeared to be different for survivors. In addition to established data registries, this consortium of regional neonatal intensive care units provides a new collaborative effort to describe short-term outcomes for infants referred with CDH.

Keywords

congenital diaphragmatic hernia - neonatal - pulmonary hypertension - prematurity - NICU - pulmonary hypoplasia - respiratory failure

* Michael A Padula, Jeanette M Asselin, David J Durand, Billie L Short, Francine D Dykes, Kristina M Reber, and Jacquelyn R Evans.


 

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