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CC BY-NC-ND 4.0 · J Neurol Surg Rep 2017; 78(01): e15-e19
DOI: 10.1055/s-0037-1598198
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Imaging and Outcomes for a New Entity: Low-Grade Sinonasal Sarcoma with Neural and Myogenic Features

Richard B. Cannon
1   Division of Otolaryngology – Head & Neck Surgery, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah, United States
3   Department of Radiology, University of Utah School of Medicine, Salt Lake City, Utah, United States
,
Richard H. Wiggins III
1   Division of Otolaryngology – Head & Neck Surgery, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah, United States
,
Benjamin L. Witt
2   The Huntsman Cancer Institute, Salt Lake City, Utah, United States
4   Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States
,
Yusuf Dundar
2   The Huntsman Cancer Institute, Salt Lake City, Utah, United States
,
Tawni M. Johnston
2   The Huntsman Cancer Institute, Salt Lake City, Utah, United States
,
Jason P. Hunt
1   Division of Otolaryngology – Head & Neck Surgery, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah, United States
2   The Huntsman Cancer Institute, Salt Lake City, Utah, United States
› Author Affiliations
Further Information

Publication History

08 June 2016

21 December 2016

Publication Date:
15 February 2017 (online)

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Abstract

Objectives Low-grade sinonasal sarcoma with neural and myogenic features (LGSSNMF) is a new, rare tumor. Our goal is to describe the imaging characteristics and surgical outcomes of this unique skull base malignancy.

Design Retrospective case series.

Setting Academic medical center.

Participants There were three patients who met inclusion criteria with a confirmed LGSSNMF.

Main Outcome Measures Imaging and histopathological characteristics, treatments, survival and recurrence outcomes, complications, morbidity, and mortality.

Results Patients presented with diplopia, facial discomfort, a supraorbital mass, and nasal obstruction. Magnetic resonance imaging and computed tomography imaging in all cases showed an enhancing sinonasal mass with associated hyperostotic bone formation that involved the frontal sinus, invaded the lamina papyracea and anterior skull base, and had intracranial extension. One patient underwent a purely endoscopic surgical resection and the second underwent a craniofacial resection, while the last is pending treatment. All patients recovered well, without morbidity or long-term complications, and are currently without evidence of disease (mean follow-up of 2.1 years). One patient recurred after 17 months and underwent a repeat endoscopic skull base and dural resection.

Conclusions The surgical outcomes and imaging of this unique, locally aggressive skull base tumor are characterized.

Keywords

low-grade sinonasal sarcoma with neural and myogenic features - skull base malignancy - imaging characteristics - surgical outcomes - hyperostotic bone formation - locally aggressive - sinonasal sarcoma

Note

Presented at the 2016 Combined Sections Meeting, January 22 to 24, Miami Beach, Florida, United States.


 

  • References

  • 1 Wu AW, Suh JD, Metson R, Wang MB. Prognostic factors in sinonasal sarcomas: analysis of the surveillance, epidemiology and end result database. Laryngoscope 2012; 122 (10) 2137-2142
    CrossrefPubMedGoogle Scholar
  • 2 Lewis JT, Oliveira AM, Nascimento AG. , et al. Low-grade sinonasal sarcoma with neural and myogenic features: a clinicopathologic analysis of 28 cases. Am J Surg Pathol 2012; 36 (04) 517-525
    CrossrefPubMedGoogle Scholar
  • 3 Powers KA, Han LM, Chiu AG, Aly FZ. Low-grade sinonasal sarcoma with neural and myogenic features--diagnostic challenge and pathogenic insight. Oral Surg Oral Med Oral Pathol Oral Radiol 2015; 119 (05) e265-e269
    CrossrefPubMedGoogle Scholar
  • 4 Riddle NN, Gardner JM. The new kids on the block: recently characterized soft tissue tumors. Surg Pathol Clin 2015; 8 (03) 467-491
    CrossrefPubMedGoogle Scholar
  • 5 Wenig BM. Recently described sinonasal tract lesions/neoplasms: considerations for the new world health organization book. Head Neck Pathol 2014; 8 (01) 33-41
    CrossrefPubMedGoogle Scholar
  • 6 Bishop JA, Thompson LD, Cardesa A. , et al. Rhabdomyoblastic differentiation in head and neck malignancies other than rhabdomyosarcoma. Head Neck Pathol 2015; 9 (04) 507-518
    CrossrefPubMedGoogle Scholar
  • 7 Turner JH, Reh DD. Incidence and survival in patients with sinonasal cancer: a historical analysis of population-based data. Head Neck 2012; 34 (06) 877-885
    CrossrefPubMedGoogle Scholar