Semin Neurol 2017; 37(03): 383-390
DOI: 10.1055/s-0037-1603510
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Organized Outpatient Care of Patients with Transient Ischemic Attack and Minor Stroke

R. A. Joundi
1   Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
,
G. Saposnik
2   Stroke Outcomes Research Unit, Division of Neurology, Department of Medicine, Institute of Health Policy, Management and Evaluation, University of Toronto, St. Michael's Hospital, Toronto, Ontario, Canada
› Author Affiliations
Further Information

Publication History

Publication Date:
31 July 2017 (online)

Abstract

The risk of recurrent stroke after transient ischemic attack (TIA) is high. In the past 10 years, TIA has increasingly been recognized as a medical emergency. Health systems have adapted toward rapid evaluation, investigation, and secondary prevention in patients with presumed TIA and minor stroke, and the significant benefits in reducing recurrent stroke and mortality have been borne out in several landmark studies. Various scores have been developed and debated to better risk stratify patients with TIA for hospitalization or urgent referral. However, scoring systems face challenges in identifying all patients with high-risk etiologies such as atrial fibrillation and carotid stenosis, and therefore require further refinement before widespread use. Further challenges include the role of advanced imaging in TIA, and ensuring rapid access to specialist care for all patients. In the absence of definitive risk stratification methods, the authors conclude that all patients with suspected TIA and minor stroke should be assessed and treated on an urgent basis, ideally through rapid outpatient referral programs.

 
  • References

  • 1 Rothwell PM, Warlow CP. Timing of TIAs preceding stroke: time window for prevention is very short. Neurology 2005; 64 (05) 817-820
  • 2 Giles MF, Rothwell PM. The need for emergency treatment of transient ischemic attack and minor stroke. Expert Rev Neurother 2005; 5 (02) 203-210
  • 3 Lovett JK, Dennis MS, Sandercock PA, Bamford J, Warlow CP, Rothwell PM. Very early risk of stroke after a first transient ischemic attack. Stroke 2003; 34 (08) e138-e140
  • 4 Johnston SC, Gress DR, Browner WS, Sidney S. Short-term prognosis after emergency department diagnosis of TIA. JAMA 2000; 284 (22) 2901-2906
  • 5 Coull AJ, Lovett JK, Rothwell PM. ; Oxford Vascular Study. Population based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services. BMJ 2004; 328 (7435): 326
  • 6 Eliasziw M, Kennedy J, Hill MD, Buchan AM, Barnett HJM. ; North American Symptomatic Carotid Endarterectomy Trial Group. Early risk of stroke after a transient ischemic attack in patients with internal carotid artery disease. CMAJ 2004; 170 (07) 1105-1109
  • 7 Stroke Unit Trialists' Collaboration. Organised inpatient (stroke unit) care for stroke. Cochrane Database Syst Rev 2013; (09) CD000197
  • 8 Chandratheva A, Lasserson DS, Geraghty OC, Rothwell PM. ; Oxford Vascular Study. Population-based study of behavior immediately after transient ischemic attack and minor stroke in 1000 consecutive patients: lessons for public education. Stroke 2010; 41 (06) 1108-1114
  • 9 Oppenheim C, Lamy C, Touzé E. , et al. Do transient ischemic attacks with diffusion-weighted imaging abnormalities correspond to brain infarctions?. AJNR Am J Neuroradiol 2006; 27 (08) 1782-1787
  • 10 Amarenco P, Lavallée PC, Labreuche J. , et al; TIAregistry.org Investigators. One-year risk of stroke after transient ischemic attack or minor stroke. N Engl J Med 2016; 374 (16) 1533-1542
  • 11 Rothwell PM, Giles MF, Chandratheva A. , et al; Early use of Existing Preventive Strategies for Stroke (EXPRESS) study. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet 2007; 370 (9596): 1432-1442
  • 12 Cates C. Dr Chris Cates' EBM Web Site. Available at: http://www.nntonline.net/visualrx/introduction . Accessed November 19, 2016
  • 13 Lavallée PC, Meseguer E, Abboud H. , et al. A transient ischaemic attack clinic with round-the-clock access (SOS-TIA): feasibility and effects. Lancet Neurol 2007; 6 (11) 953-960
  • 14 Webster F, Saposnik G, Kapral MK, Fang J, O'Callaghan C, Hachinski V. Organized outpatient care: stroke prevention clinic referrals are associated with reduced mortality after transient ischemic attack and ischemic stroke. Stroke 2011; 42 (11) 3176-3182
  • 15 Wasserman J, Perry J, Dowlatshahi D. , et al. Stratified, urgent care for transient ischemic attack results in low stroke rates. Stroke 2010; 41 (11) 2601-2605
  • 16 Torres Macho J, Peña Lillo G, Pérez Martínez D. , et al. Outcomes of atherothrombotic transient ischemic attack and minor stroke in an emergency department: results of an outpatient management program. Ann Emerg Med 2011; 57 (05) 510-516
  • 17 Olivot J-M, Wolford C, Castle J. , et al. Two aces: transient ischemic attack work-up as outpatient assessment of clinical evaluation and safety. Stroke 2011; 42 (07) 1839-1843
  • 18 Wu CM, Manns BJ, Hill MD, Ghali WA, Donaldson C, Buchan AM. Rapid evaluation after high-risk TIA is associated with lower stroke risk. Can J Neurol Sci 2009; 36 (04) 450-455
  • 19 Hörer S, Schulte-Altedorneburg G, Haberl RL. Management of patients with transient ischemic attack is safe in an outpatient clinic based on rapid diagnosis and risk stratification. Cerebrovasc Dis 2011; 32 (05) 504-510
  • 20 Guarino M, Rondelli F, Favaretto E. , et al. Short- and long-term stroke risk after urgent management of transient ischaemic attack: the Bologna TIA clinical pathway. Eur Neurol 2015; 74 (1-2): 1-7
  • 21 Hackam DG, Spence JD. Combining multiple approaches for the secondary prevention of vascular events after stroke: a quantitative modeling study. Stroke 2007; 38 (06) 1881-1885
  • 22 Rothwell PM, Algra A, Chen Z, Diener H-C, Norrving B, Mehta Z. Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: time-course analysis of randomised trials. Lancet 2016; 388 (10042): 365-375
  • 23 O'Donnell MJ, Chin SL, Rangarajan S. , et al; INTERSTROKE investigators. Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study. Lancet 2016; 388 (10046): 761-775
  • 24 Dahlöf B, Devereux R, de Faire U. , et al; The LIFE Study Group. The Losartan Intervention For Endpoint reduction (LIFE) in Hypertension study: rationale, design, and methods. Am J Hypertens 1997; 10 (7 Pt 1): 705-713
  • 25 Lithell H, Hansson L, Skoog I. , et al; SCOPE Study Group. The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial. J Hypertens 2003; 21 (05) 875-886
  • 26 PROGRESS Collaborative Group. Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet 2001; 358 (9287): 1033-1041
  • 27 Davis BR, Whelton PK. ; ALLHAT Collaborative Research Group. Benazepril plus amlodipine or hydrochlorothiazide for hypertension. N Engl J Med 2009; 360 (11) 1148-1149 , author reply 1149–1150
  • 28 Mihaylova B, Emberson J, Blackwell L. , et al; Cholesterol Treatment Trialists' (CTT) Collaborators. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet 2012; 380 (9841): 581-590
  • 29 Amarenco P, Bogousslavsky J, Callahan III A. , et al; Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 2006; 355 (06) 549-559
  • 30 Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med 2007; 146 (12) 857-867
  • 31 Ruff CT, Giugliano RP, Braunwald E. , et al. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet 2014; 383 (9921): 955-962
  • 32 Rothwell PM, Eliasziw M, Gutnikov SA, Warlow CP, Barnett HJM. ; Carotid Endarterectomy Trialists Collaboration. Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery. Lancet 2004; 363 (9413): 915-924
  • 33 Coutts SB, Wein TH, Lindsay MP. , et al; Heart, and Stroke Foundation Canada Canadian Stroke Best Practices Advisory Committee. Canadian Stroke Best Practice Recommendations: secondary prevention of stroke guidelines, update 2014. Int J Stroke 2015; 10 (03) 282-291
  • 34 Donnan GA, Davis SM, Hill MD, Gladstone DJ. Patients with transient ischemic attack or minor stroke should be admitted to hospital. Stroke 2006; 37 (04) 1137-1138
  • 35 Gubitz G, Phillips S, Dwyer V. What is the cost of admitting patients with transient ischaemic attacks to hospital?. Cerebrovasc Dis 1999; 9 (04) 210-214
  • 36 Ovbiagele B, Saver JL, Fredieu A. , et al. In-hospital initiation of secondary stroke prevention therapies yields high rates of adherence at follow-up. Stroke 2004; 35 (12) 2879-2883
  • 37 Scholte op Reimer WJ, Dippel DW, Franke CL. , et al. Quality of hospital and outpatient care after stroke or transient ischemic attack: insights from a stroke survey in the Netherlands. Stroke 2006; 37 (07) 1844-1849
  • 38 Kapral MK, Hall R, Fang J. , et al. Association between hospitalization and care after transient ischemic attack or minor stroke. Neurology 2016; 86 (17) 1582-1589
  • 39 Tsai JP, Rochon PA, Raptis S, Bronskill SE, Bell CM, Saposnik G. A prescription at discharge improves long-term adherence for secondary stroke prevention. J Stroke Cerebrovasc Dis 2014; 23 (09) 2308-2315
  • 40 Paul NLM, Koton S, Simoni M, Geraghty OC, Luengo-Fernandez R, Rothwell PM. Feasibility, safety and cost of outpatient management of acute minor ischaemic stroke: a population-based study. J Neurol Neurosurg Psychiatry 2013; 84 (03) 356-361
  • 41 Nguyen-Huynh MN, Johnston SC. Is hospitalization after TIA cost-effective on the basis of treatment with tPA?. Neurology 2005; 65 (11) 1799-1801
  • 42 Warrior L, Prabhakaran S. Transient ischemic attack evaluation models: hospitalization, same-day clinics, or rapid evaluation units. Am J Ther 2011; 18 (01) 45-50
  • 43 Nahab F, Leach G, Kingston C. , et al. Impact of an emergency department observation unit transient ischemic attack protocol on length of stay and cost. J Stroke Cerebrovasc Dis 2012; 21 (08) 673-678
  • 44 Canadian Stroke Best Practices. Available at: http://www.strokebestpractices.ca/ . Accessed November 19, 2016
  • 45 Kamal N, Hill MD, Blacquiere DPV. , et al. Rapid assessment and treatment of transient ischemic attacks and minor stroke in Canadian emergency departments: time for a paradigm shift. Stroke 2015; 46 (10) 2987-2990
  • 46 Johnston SC, Rothwell PM, Nguyen-Huynh MN. , et al. Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet 2007; 369 (9558): 283-292
  • 47 Rothwell PM, Giles MF, Flossmann E. , et al. A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. Lancet 2005; 366 (9479): 29-36
  • 48 Tsivgoulis G, Stamboulis E, Sharma VK. , et al. Multicenter external validation of the ABCD2 score in triaging TIA patients. Neurology 2010; 74 (17) 1351-1357
  • 49 Stroke and transient ischaemic attack in over 16s: diagnosis and initial management. Available at: https://www.nice.org.uk/guidance/cg68 . Accessed November 19, 2016
  • 50 Amarenco P, Labreuche J, Lavallée PC. Patients with transient ischemic attack with ABCD2 <4 can have similar 90-day stroke risk as patients with transient ischemic attack with ABCD2 ≥4. Stroke 2012; 43 (03) 863-865
  • 51 Josephson SA, Sidney S, Pham TN, Bernstein AL, Johnston SC. Higher ABCD2 score predicts patients most likely to have true transient ischemic attack. Stroke 2008; 39 (11) 3096-3098
  • 52 Bradley D, Cronin S, Kinsella JA. , et al. Frequent inaccuracies in ABCD2 scoring in non-stroke specialists' referrals to a daily Rapid Access Stroke Prevention service. J Neurol Sci 2013; 332 (1-2): 30-34
  • 53 Perry JJ, Sharma M, Sivilotti MLA. , et al. Prospective validation of the ABCD2 score for patients in the emergency department with transient ischemic attack. CMAJ 2011; 183 (10) 1137-1145
  • 54 Coutts SB, Eliasziw M, Hill MD. , et al; VISION study group. An improved scoring system for identifying patients at high early risk of stroke and functional impairment after an acute transient ischemic attack or minor stroke. Int J Stroke 2008; 3 (01) 3-10
  • 55 Giles MF, Albers GW, Amarenco P. , et al. Addition of brain infarction to the ABCD2 Score (ABCD2I): a collaborative analysis of unpublished data on 4574 patients. Stroke 2010; 41 (09) 1907-1913
  • 56 Yaghi S, Rostanski SK, Boehme AK. , et al. Imaging parameters and recurrent cerebrovascular events in patients with minor stroke or transient ischemic attack. JAMA Neurol 2016; 73 (05) 572-578
  • 57 Merwick A, Albers GW, Amarenco P. , et al. Addition of brain and carotid imaging to the ABCD2 score to identify patients at early risk of stroke after transient ischaemic attack: a multicentre observational study. Lancet Neurol 2010; 9 (11) 1060-1069
  • 58 Giles MF, Albers GW, Amarenco P. , et al. Early stroke risk and ABCD2 score performance in tissue- vs time-defined TIA: a multicenter study. Neurology 2011; 77 (13) 1222-1228
  • 59 Wardlaw J, Brazzelli M, Miranda H. , et al. An assessment of the cost-effectiveness of magnetic resonance, including diffusion-weighted imaging, in patients with transient ischaemic attack and minor stroke: a systematic review, meta-analysis and economic evaluation. Health Technol Assess 2014; 18 (27) 1-368 , v–vi
  • 60 Ay H, Buonanno FS, Rordorf G. , et al. Normal diffusion-weighted MRI during stroke-like deficits. Neurology 1999; 52 (09) 1784-1792
  • 61 Wessels T, Röttger C, Jauss M, Kaps M, Traupe H, Stolz E. Identification of embolic stroke patterns by diffusion-weighted MRI in clinically defined lacunar stroke syndromes. Stroke 2005; 36 (04) 757-761
  • 62 Smith EE, O'Donnell M, Dagenais G. , et al; PURE Investigators. Early cerebral small vessel disease and brain volume, cognition, and gait. Ann Neurol 2015; 77 (02) 251-261
  • 63 van der Holst HM, van Uden IWM, Tuladhar AM. , et al. Factors associated with 8-year mortality in older patients with cerebral small vessel disease: The Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC) Study. JAMA Neurol 2016; 73 (04) 402-409
  • 64 Batchelor FA, Williams SB, Wijeratne T, Said CM, Petty S. Balance and gait impairment in transient ischemic attack and minor stroke. J Stroke Cerebrovasc Dis 2015; 24 (10) 2291-2297
  • 65 Kenmuir CL, Hammer M, Jovin T, Reddy V, Wechsler L, Jadhav A. Predictors of outcome in patients presenting with acute ischemic stroke and mild stroke scale scores. J Stroke Cerebrovasc Dis 2015; 24 (07) 1685-1689
  • 66 Kerr E, Arulraj N, Scott M. , et al. A telephone hotline for transient ischaemic attack and stroke: prospective audit of a model to improve rapid access to specialist stroke care. BMJ 2010; 341: c3265
  • 67 Ferro JM, Falcão I, Rodrigues G. , et al. Diagnosis of transient ischemic attack by the nonneurologist. A validation study. Stroke 1996; 27 (12) 2225-2229
  • 68 Martin PJ, Young G, Enevoldson TP, Humphrey PR. Overdiagnosis of TIA and minor stroke: experience at a regional neurovascular clinic. QJM 1997; 90 (12) 759-763
  • 69 Rothwell PM, Eliasziw M, Gutnikov SA. , et al; Carotid Endarterectomy Trialists' Collaboration. Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis. Lancet 2003; 361 (9352): 107-116
  • 70 Easton JD, Saver JL, Albers GW. , et al; American Heart Association; American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; Interdisciplinary Council on Peripheral Vascular Disease. Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease. The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists. Stroke 2009; 40 (06) 2276-2293