Download PDF
CC BY-NC-ND 4.0 · Rev Bras Ginecol Obstet 2017; 39(12): 686-691
DOI: 10.1055/s-0037-1604065
Systematic Review
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Is Pethidine Safe during Labor? Systematic Review

A petidina é segura durante o trabalho de parto? Revisão sistemática
Rogevando Rodrigues Nunes
1   Obstetrician, Postgraduate vice-rectory, Health Science Center, MSc in Medical Sciences, Universidade de Fortaleza (UNIFOR), Fortaleza, CE, Brazil
,
Paulo Giordano Baima Colares
2   Orthopedist/Traumatology, Universidade de Fortaleza (UNIFOR), Fortaleza, CE, Brazil
,
Juliana Pinto Montenegro
3   Physiotherapist, Universidade de Fortaleza (UNIFOR), Fortaleza, CE, Brazil
› Author Affiliations
Further Information

Publication History

23 February 2017

19 April 2017

Publication Date:
30 June 2017 (online)

   Permissions and Reprints

Abstract

Purpose To verify if pethidine is safe for the conceptus when used during labor.

Methods Systematic review in the Capes Periodicals/PubMed and MEDLINE/Virtual Health Library (BVS, in the Portuguese acronym) databases.

Results A total of 17 studies published from January 1st, 2000, to September 2nd, 2016, with a total of 1,688 participants involved were included in the present review. There was no record of conceptus vitality decrease associated with low doses of pethidine being administered to mothers during labor.

Conclusions Intramuscular (IM) or intravenous (IV) pethidine at low doses, of up to 50 mg, is safe to administer during labor.

Resumo

Objetivo Verificar se a petidina é segura para o concepto quando utilizada durante o trabalho de parto.

Método Revisão sistemática nas bases de dados dos Periódicos Capes/PubMed e MEDLINE/Biblioteca Virtual em Saúde (BVS).

Resultados Um total de 17 estudos, publicados de 1° de janeiro de 2000 a 2 de setembro de 2016, totalizando 1.688 participantes envolvidos, foram incluídos nesta revisão. Não houve registro de depressão na vitalidade dos conceptos com doses baixas de petidina administradas às mães durante o trabalho de parto.

Conclusão Petidina intramuscular (IM) ou intravenosa (IV) em baixas doses, de até 50 mg, é segura durante o trabalho de parto.

Keywords

pethidine - safety - labor

Palavras-chave

petidina - segurança - trabalho de parto

Note

This study was conducted in partnership with Universidade de of Fortaleza (UNIFOR), through the access granted to the digital library of the institution. The authors are part of the MSc Academic Course in Medical Sciences at UNIFOR.


 

  • References

  • 1 Ronconi APL, Perdichizzi FS, Pires OC, Constantino E, Lopes VR, Posso IP. Dor e satisfação durante o trabalho de parto em primigestas: visão da parturiente e do obstetra. Rev Dor. 2010; 11 (04) 277-281
    PubMedGoogle Scholar
  • 2 Nilsen E, Sabatino H, Lopes MHBM. The pain and behavior of women during labor and the different positions for childbirth. Rev Esc Enferm USP 2011; 45 (03) 557-565
    CrossrefPubMedGoogle Scholar
  • 3 Chestnut DH, Wong CA, Tsen LC, Kee WDN, Beilin Y, Mhyre J. Anestesia obstétrica: princípios e prática. 5a ed. Rio de Janeiro: Elsevier; 2016
    Google Scholar
  • 4 Koren G. Medication safety in pregnancy & breastfeeding. New York: McGraw-Hill; 2007
    Google Scholar
  • 5 Kandel PF, Spoerel WE, Kinch RAH. Continuous epidural analgesia for labour and delivery: review of 1000 cases. Can Med Assoc J 1966; 95 (19) 947-953
    PubMedGoogle Scholar
  • 6 Shahriari A, Khooshideh M. A randomized controlled trial of intravenous remifentanil compared with intramuscular meperidine for pain relief in labor. J Med Sci 2007; 7 (04) 635-639
    CrossrefPubMedGoogle Scholar
  • 7 Barnes J. Pethidine in labour; results in 500 cases. BMJ 1947; 1 (4500): 437-442
    CrossrefPubMedGoogle Scholar
  • 8 Bismarck JA. Analgesia em obstetrícia. Lisboa: Permanyer Portugal; 2002
    Google Scholar
  • 9 Abu Dayyh W, El Tannir D, Mallah E. , et al. Pethidine level in Jordanian women and their newborns during labor after a single intravenous dose. Int J Clin Anesthesiol. 2014; 2 (03) 1-7
    PubMedGoogle Scholar
  • 10 Freitas JF, Meinberg S. Analgesia de parto: bloqueios locorregionais e analgesia sistêmica. Rev Med Minas Gerais. 2009; 19 (03) (Suppl. 01) S7-S14
    PubMedGoogle Scholar
  • 11 Reynolds F. Labour analgesia and the baby: good news is no news. Int J Obstet Anesth 2011; 20 (01) 38-50
    CrossrefPubMedGoogle Scholar
  • 12 Minson FP, Ferracini FT, Fernandes Júnior CJ, Sardá Júnior J, Lopes ACB. Redução do uso de Petidina em hospital privado com a implantação de um programa educativo multiprofissional. Rev Dor. 2011; 12 (01) 35-38
    CrossrefPubMedGoogle Scholar
  • 13 Dastur AE. Intrapartum fetal distress. J Obstet Gynaecol India 2005; 55 (02) 115-117
    PubMedGoogle Scholar
  • 14 Yaksh TL, Wallace MS. Opioids, analgesia, and pain management. In: Brunton LL, Chabner BA, Knollmann BC. , editors. Goodman and Gilman's the pharmacological basis of therapeutics. 12th ed. New York: McGraw-Hill; 2011. . p. 481–526
    Google Scholar
  • 15 Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk. 9th ed. Philadelphia: Lippincott Williams & Wilkins; 2011. . Promethazine; p. 1219–20
    Google Scholar
  • 16 El-Refaie TA, El-Said MM, Shoukry AA, Khafagy SM, El-Din AS, Badawy MM. Meperidine for uterine dystocia and its effect on duration of labor and neonatal acid-base status: a randomized clinical trial. J Obstet Gynaecol Res 2012; 38 (02) 383-389
    CrossrefPubMedGoogle Scholar
  • 17 Khooshideh M, Shahriari A. A comparison of tramadol and pethidine analgesia on the duration of labour: a randomised clinical trial. Aust N Z J Obstet Gynaecol 2009; 49 (01) 59-63
    CrossrefPubMedGoogle Scholar
  • 18 Allameh Z, Tehrani HG, Ghasemi M. Comparing the impact of acupuncture and pethidine on reducing labor pain. Adv Biomed Res 2015; 4: 46
    CrossrefPubMedGoogle Scholar
  • 19 Yilmaz B, Kart C, Kelekci S. , et al. Meperidine versus valethamate bromide in shortening the duration of active labor. Int J Gynaecol Obstet 2009; 107 (02) 126-129
    CrossrefPubMedGoogle Scholar
  • 20 Sekhavat L, Behdad S. The effects of meperidine analgesia during labor on fetal heart rate. Int J Biomed Sci 2009; 5 (01) 59-62
    PubMedGoogle Scholar
  • 21 Ng TKT, Cheng BCP, Chan WS, Lam KK, Chan MTV. A double-blind randomised comparison of intravenous patient-controlled remifentanil with intramuscular pethidine for labour analgesia. Anaesthesia 2011; 66 (09) 796-801
    CrossrefPubMedGoogle Scholar
  • 22 Elbohoty AEH, Abd-Elrazek H, Abd-El-Gawad M, Salama F, El-Shorbagy M, Abd-El-Maeboud KHI. Intravenous infusion of paracetamol versus intravenous pethidine as an intrapartum analgesic in the first stage of labor. Int J Gynaecol Obstet 2012; 118 (01) 7-10
    CrossrefPubMedGoogle Scholar
  • 23 Fleet J, Belan I, Jones MJ, Ullah S, Cyna AM. A comparison of fentanyl with pethidine for pain relief during childbirth: a randomised controlled trial. BJOG 2015; 122 (07) 983-992
    CrossrefPubMedGoogle Scholar
  • 24 Loughnan BA, Carli F, Romney M, Doré CJ, Gordon H. Randomized controlled comparison of epidural bupivacaine versus pethidine for analgesia in labour. Br J Anaesth 2000; 84 (06) 715-719
    CrossrefPubMedGoogle Scholar
  • 25 Keskin HL, Keskin EA, Avsar AF, Tabuk M, Caglar GS. Pethidine versus tramadol for pain relief during labor. Int J Gynaecol Obstet 2003; 82 (01) 11-16
    CrossrefPubMedGoogle Scholar
  • 26 Wee MYK, Tuckey JP, Thomas PW, Burnard S. A comparison of intramuscular diamorphine and intramuscular pethidine for labour analgesia: a two-centre randomised blinded controlled trial. BJOG 2014; 121 (04) 447-456
    CrossrefPubMedGoogle Scholar
  • 27 Sosa CG, Balaguer E, Alonso JG, Panizza R, Laborde A, Berrondo C. Meperidine for dystocia during the first stage of labor: A randomized controlled trial. Am J Obstet Gynecol 2004; 191 (04) 1212-1218
    CrossrefPubMedGoogle Scholar
  • 28 Sharma SK, Alexander JM, Messick G. , et al. Cesarean delivery: a randomized trial of epidural analgesia versus intravenous meperidine analgesia during labor in nulliparous women. Anesthesiology 2002; 96 (03) 546-551
    CrossrefPubMedGoogle Scholar
  • 29 Sosa CG, Buekens P, Hughes JM. , et al. Effect of pethidine administered during the first stage of labor on the acid-base status at birth. Eur J Obstet Gynecol Reprod Biol 2006; 129 (02) 135-139
    CrossrefPubMedGoogle Scholar
  • 30 Tsui MHY, Ngan Kee WD, Ng FF, Lau TK. A double blinded randomised placebo-controlled study of intramuscular pethidine for pain relief in the first stage of labour. BJOG 2004; 111 (07) 648-655
    CrossrefPubMedGoogle Scholar
  • 31 Douma MR, Verwey RA, Kam-Endtz CE, van der Linden PD, Stienstra R. Obstetric analgesia: a comparison of patient-controlled meperidine, remifentanil, and fentanyl in labour. Br J Anaesth 2010; 104 (02) 209-215
    CrossrefPubMedGoogle Scholar
  • 32 Jain S, Arya VK, Gopalan S, Jain V. Analgesic efficacy of intramuscular opioids versus epidural analgesia in labor. Int J Gynaecol Obstet 2003; 83 (01) 19-27
    CrossrefPubMedGoogle Scholar
  • 33 Halpern SH, Littleford JA, Brockhurst NJ, Youngs PJ, Malik N, Owen HC. The neurologic and adaptive capacity score is not a reliable method of newborn evaluation. Anesthesiology 2001; 94 (06) 958-962
    CrossrefPubMedGoogle Scholar
  • 34 Apgar V. A proposal for a new method of evaluation of the newborn infant. Curr Res Anest Anal 1953; 32 (04) 260-267
    PubMedGoogle Scholar