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Z Gastroenterol 2017; 55(09): 883-936
DOI: 10.1055/s-0043-116856
DOI: 10.1055/s-0043-116856
Leitlinie
S2k-Leitlinie Gastrointestinale Blutung
AWMF-Register Nr. 021–28S2k Guideline Gastrointestinal BleedingGuideline of the German Society of Gastroenterology DGVSFurther Information
Publication History
Publication Date:
12 September 2017 (online)
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Literatur
- 1 Gralnek IM, Dumonceau JM, Kuipers EJ. et al. Diagnosis and management of nonvariceal upper gastrointestinal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy 2015; 47: a1-a46
- 2 Denzer U, Beilenhoff U, Eickhoff A. et al. S2k guideline: quality requirements for gastrointestinal endoscopy, AWMF registry no. 021-022. Zeitschrift fur Gastroenterologie 2015; 53: 1496-1530
- 3 Wacharasint P, Nakada TA, Boyd JH. et al. Normal-range blood lactate concentration in septic shock is prognostic and predictive. Shock 2012; 38: 4-10
- 4 Nguyen HB, Rivers EP, Knoblich BP. et al. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med 2004; 32: 1637-1642
- 5 Koch A, Buendgens L, Duckers H. et al. Bleeding origin, patient-related risk factors, and prognostic indicators in patients with acute gastrointestinal hemorrhages requiring intensive care treatment. A retrospective analysis from 1999 to 2010. Medizinische Klinik, Intensivmedizin und Notfallmedizin 2013; 108: 214-222
- 6 Rockey DC, Elliott A, Lyles T. Prediction of esophageal varices and variceal hemorrhage in patients with acute upper gastrointestinal bleeding. Journal of investigative medicine: the official publication of the American Federation for Clinical Research 2016; 64: 745-751
- 7 Castera L, Pinzani M, Bosch J. Non invasive evaluation of portal hypertension using transient elastography. Journal of hepatology 2012; 56: 696-703
- 8 Salzl P, Reiberger T, Ferlitsch M. et al. Evaluation of portal hypertension and varices by acoustic radiation force impulse imaging of the liver compared to transient elastography and AST to platelet ratio index. Ultraschall in Med 2014; 35: 528-533
- 9 Attia D, Schoenemeier B, Rodt T. et al. Evaluation of Liver and Spleen Stiffness with Acoustic Radiation Force Impulse Quantification Elastography for Diagnosing Clinically Significant Portal Hypertension. Ultraschall in Med 2015; 36: 603-610
- 10 Takuma Y, Nouso K, Morimoto Y. et al. Prediction of oesophageal variceal bleeding by measuring spleen stiffness in patients with liver cirrhosis. Gut 2016; 65: 354-355
- 11 Blatchford O, Murray WR, Blatchford M. A risk score to predict need for treatment for upper-gastrointestinal haemorrhage. Lancet 2000; 356: 1318-1321
- 12 Cheng DW, Lu YW, Teller T. et al. A modified Glasgow Blatchford Score improves risk stratification in upper gastrointestinal bleed: a prospective comparison of scoring systems. Alimentary pharmacology & therapeutics 2012; 36: 782-789
- 13 Stanley AJ. Update on risk scoring systems for patients with upper gastrointestinal haemorrhage. World journal of gastroenterology: WJG 2012; 18: 2739-2744
- 14 Rockall TA, Logan RF, Devlin HB. et al. Risk assessment after acute upper gastrointestinal haemorrhage. Gut 1996; 38: 316-321
- 15 Dicu D, Pop F, Ionescu D. et al. Comparison of risk scoring systems in predicting clinical outcome at upper gastrointestinal bleeding patients in an emergency unit. Am J Emerg Med 2013; 31: 94-99
- 16 de Franchis R, Baveno VIF. Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension. Journal of hepatology 2015; 63: 743-752
- 17 Laine L. Risk Assessment Tools for Gastrointestinal Bleeding. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 2016; 14: 1571-1573
- 18 Aoki T, Nagata N, Shimbo T. et al. Development and Validation of a Risk Scoring System for Severe Acute Lower Gastrointestinal Bleeding. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 2016; 14: 1562-1570 e1562
- 19 Camus M, Jensen DM, Ohning GV. et al. Comparison of Three Risk Scores to Predict Outcomes of Severe Lower Gastrointestinal Bleeding. Journal of clinical gastroenterology 2016; 50: 52-58
- 20 Patel R, Clancy R, Crowther E. et al. A rectal bleeding algorithm can successfully reduce emergency admissions. Colorectal disease: the official journal of the Association of Coloproctology of Great Britain and Ireland 2014; 16: 377-381
- 21 Pasha SF, Shergill A. Committee ASoP. et al. The role of endoscopy in the patient with lower GI bleeding. Gastrointestinal endoscopy 2014; 79: 875-885
- 22 Lin HJ, Wang K, Perng CL. et al. Early or delayed endoscopy for patients with peptic ulcer bleeding. A prospective randomized study. Journal of clinical gastroenterology 1996; 22: 267-271
- 23 Lim LG, Ho KY, Chan YH. et al. Urgent endoscopy is associated with lower mortality in high-risk but not low-risk nonvariceal upper gastrointestinal bleeding. Endoscopy 2011; 43: 300-306
- 24 Robertson M, Majumdar A, Boyapati R. et al. Risk stratification in acute upper GI bleeding: comparison of the AIMS65 score with the Glasgow-Blatchford and Rockall scoring systems. Gastrointestinal endoscopy 2016; 83: 1151-1160
- 25 Garcia-Tsao G, Bosch J. Management of varices and variceal hemorrhage in cirrhosis. The New England journal of medicine 2010; 362: 823-832
- 26 Tripathi D, Stanley AJ, Hayes PC. et al. U.K. guidelines on the management of variceal haemorrhage in cirrhotic patients. Gut 2015; 64: 1680-1704
- 27 Villanueva C, Piqueras M, Aracil C. et al. A randomized controlled trial comparing ligation and sclerotherapy as emergency endoscopic treatment added to somatostatin in acute variceal bleeding. Journal of hepatology 2006; 45: 560-567
- 28 Bañares R, Albillos A, Rincón D. et al. Endoscopic treatment versus endoscopic plus pharmacologic treatment for acute variceal bleeding: a meta-analysis. Hepatology 2002; 35: 609-615
- 29 Tripathi D, Stanley AJ, Hayes PC. et al. UK guidelines on the management of variceal haemorrhage in cirrhotic patients. Gut 2015; 64: 1680-1704
- 30 Carbonell N, Pauwels A, Serfaty L. et al. Improved survival after variceal bleeding in patients with cirrhosis over the past two decades. Hepatology 2004; 40: 652-659
- 31 Hreinsson JP, Gumundsson S, Kalaitzakis E. et al. Lower gastrointestinal bleeding: incidence, etiology, and outcomes in a population-based setting. European journal of gastroenterology & hepatology 2013; 25: 37-43
- 32 Gomez-Outes A, Suarez-Gea ML, Lecumberri R. et al. Direct oral anticoagulants in the treatment of venous thromboembolism, with a focus on patients with pulmonary embolism: an evidence-based review. Vasc Health Risk Manag 2014; 10: 627-639
- 33 Gomez-Outes A, Terleira-Fernandez AI, Lecumberri R. et al. Direct oral anticoagulants in the treatment of acute venous thromboembolism: a systematic review and meta-analysis. Thrombosis research 2014; 134: 774-782
- 34 Strate LL. Lower GI bleeding: epidemiology and diagnosis. Gastroenterology clinics of North America 2005; 34: 643-664
- 35 Strate LL, Saltzman JR, Ookubo R. et al. Validation of a clinical prediction rule for severe acute lower intestinal bleeding. The American journal of gastroenterology 2005; 100: 1821-1827
- 36 Meier A, Messmann H, Golder SK. Endoscopic management of lower gastrointestinal bleeding. Medizinische Klinik, Intensivmedizin und Notfallmedizin 2015; 110: 515-520
- 37 Repaka A, Atkinson MR, Faulx AL. et al. Immediate unprepared hydroflush colonoscopy for severe lower GI bleeding: a feasibility study. Gastrointestinal endoscopy 2012; 76: 367-373
- 38 Braun JP, Kumpf O, Deja M. et al. The German quality indicators in intensive care medicine 2013--second edition. Ger Med Sci 2013; 11: Doc09
- 39 Wehrmann T, Riphaus A. Sedation with propofol for interventional endoscopic procedures: a risk factor analysis. Scandinavian journal of gastroenterology 2008; 43: 368-374
- 40 Riphaus A, Wehrmann T, Hausmann J. et al. S3-guidelines "sedation in gastrointestinal endoscopy" 2014 (AWMF register no. 021/014). Zeitschrift für Gastroenterologie 2015; 53: E1
- 41 Ogasawara N, Mizuno M, Masui R. et al. Predictive factors for intractability to endoscopic hemostasis in the treatment of bleeding gastroduodenal peptic ulcers in Japanese patients. Clin Endosc 2014; 47: 162-173
- 42 Braun G, Messmann H. New therapeutical options for heavy gastrointestinal bleeding. Dtsch Med Wochenschr 2015; 140: 888-891
- 43 Garcia-Pagan JC, Caca K, Bureau C. et al. Early use of TIPS in patients with cirrhosis and variceal bleeding. The New England journal of medicine 2010; 362: 2370-2379
- 44 Hubmann R, Bodlaj G, Czompo M. et al. The use of self-expanding metal stents to treat acute esophageal variceal bleeding. Endoscopy 2006; 38: 896-901
- 45 European Association for the Study of the Liver. Electronic address eee. EASL Clinical Practice Guidelines: Liver transplantation. Journal of hepatology 2016; 64: 433-485
- 46 Baradarian R, Ramdhaney S, Chapalamadugu R. et al. Early intensive resuscitation of patients with upper gastrointestinal bleeding decreases mortality. The American journal of gastroenterology 2004; 99: 619-622
- 47 Kwan I, Bunn F, Chinnock P. et al. Timing and volume of fluid administration for patients with bleeding. The Cochrane database of systematic reviews 2014; 3 DOI: CD002245.
- 48 Marx G, Schindler AW, Mosch C. et al. Intravascular volume therapy in adults: Guidelines from the Association of the Scientific Medical Societies in Germany. European journal of anaesthesiology 2016; DOI: 10.1097/EJA.0000000000000447.
- 49 Gattas DJ, Dan A, Myburgh J. et al. Fluid resuscitation with 6 % hydroxyethyl starch (130/0.4 and 130/0.42) in acutely ill patients: systematic review of effects on mortality and treatment with renal replacement therapy. Intensive Care Med 2013; 39: 558-568
- 50 Annane D, Siami S, Jaber S. et al. Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial. JAMA: the journal of the American Medical Association 2013; 310: 1809-1817
- 51 Bruells CS, Schindler A, Marx G. The role of colloids in intensive care medicine. Evidence instead of emotions. Medizinische Klinik, Intensivmedizin und Notfallmedizin 2015; 110: 133-137
- 52 Dellinger RP, Levy MM, Rhodes A. et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013; 41: 580-637
- 53 Beloncle F, Meziani F, Lerolle N. et al. Does vasopressor therapy have an indication in hemorrhagic shock?. Annals of intensive care 2013; 3: 13
- 54 Shah A, Stanworth SJ, McKechnie S. Evidence and triggers for the transfusion of blood and blood products. Anaesthesia 2015; 70 (Suppl. 01) 10–19, e13–15
- 55 Villanueva C, Colomo A, Bosch A. et al. Transfusion strategies for acute upper gastrointestinal bleeding. The New England journal of medicine 2013; 368: 11-21
- 56 Jairath V, Kahan BC, Gray A. et al. Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomised feasibility trial. Lancet 2015; 386: 137-144
- 57 (BÄK). B. Querschnitts-Leitlinie der Bundesärztekammer (BÄK) zur Therapie mit Blutkomponenten und Plasmaderivaten (4. überarbeitete und aktualisierte Auflage 2014). 2014
- 58 Hwang JH, Fisher DA, Ben-Menachem T. et al. The role of endoscopy in the management of acute non-variceal upper GI bleeding. Gastrointestinal endoscopy 2012; 75: 1132-1138
- 59 Barkun AN, Bardou M, Martel M. et al. Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointestinal endoscopy 2010; 72: 1138-1145
- 60 Sreedharan A, Martin J, Leontiadis GI. et al. Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding. The Cochrane database of systematic reviews 2010; DOI: 0.1002/14651858.CD005415.pub3:CD005415.
- 61 Sachar H, Vaidya K, Laine L. Intermittent vs continuous proton pump inhibitor therapy for high-risk bleeding ulcers: a systematic review and meta-analysis. JAMA internal medicine 2014; 174: 1755-1762
- 62 Tripathi D, Stanley AJ, Hayes PC. et al. U.K. guidelines on the management of variceal haemorrhage in cirrhotic patients. Gut 2015; 64: 1680-1704
- 63 Kim KR, Jun CH, Cho KM. et al. Can proton pump inhibitors reduce rebleeding following Histoacryl sclerotherapy for gastric variceal hemorrhage?. The Korean journal of internal medicine 2015; 30: 593-601
- 64 Dultz G, Piiper A, Zeuzem S. et al. Proton pump inhibitor treatment is associated with the severity of liver disease and increased mortality in patients with cirrhosis. Alimentary pharmacology & therapeutics 2015; 41: 459-466
- 65 Min YW, Lim KS, Min BH. et al. Proton pump inhibitor use significantly increases the risk of spontaneous bacterial peritonitis in 1965 patients with cirrhosis and ascites: a propensity score matched cohort study. Alimentary pharmacology & therapeutics 2014; 40: 695-704
- 66 D'Amico G, Pagliaro L, Bosch J. The treatment of portal hypertension: a meta-analytic review. Hepatology 1995; 22: 332-354
- 67 Wells M, Chande N, Adams P. et al. Meta-analysis: vasoactive medications for the management of acute variceal bleeds. Alimentary pharmacology & therapeutics 2012; 35: 1267-1278
- 68 Villanueva C, Ortiz J, Sabat M. et al. Somatostatin alone or combined with emergency sclerotherapy in the treatment of acute esophageal variceal bleeding: a prospective randomized trial. Hepatology 1999; 30: 384-389
- 69 Sung JJ, Chung SC, Yung MY. et al. Prospective randomised study of effect of octreotide on rebleeding from oesophageal varices after endoscopic ligation. Lancet 1995; 346: 1666-1669
- 70 Besson I, Ingrand P, Person B. et al. Sclerotherapy with or without octreotide for acute variceal bleeding. The New England journal of medicine 1995; 333: 555-560
- 71 Azam Z, Hamid S, Jafri W. et al. Short course adjuvant terlipressin in acute variceal bleeding: a randomized double blind dummy controlled trial. Journal of hepatology 2012; 56: 819-824
- 72 Seo YS, Park SY, KIM MY. et al. Lack of difference among terlipressin, somatostatin, and octreotide in the control of acute gastroesophageal variceal hemorrhage. Hepatology 2014; 60: 954-963
- 73 Chavez-Tapia NC, Barrientos-Gutierrez T, Tellez-Avila F. et al. Meta-analysis: antibiotic prophylaxis for cirrhotic patients with upper gastrointestinal bleeding – an updated Cochrane review. Alimentary pharmacology & therapeutics 2011; 34: 509-518
- 74 Fernandez J, Ruiz del Arbol L, Gomez C. et al. Norfloxacin vs ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage. Gastroenterology 2006; 131: 1049-1056 ; quiz 1285
- 75 Engelmann L, Schmitt DV. Tarragona strategy--appropriate antibiotic therapy in the ICU. Medizinische Klinik, Intensivmedizin und Notfallmedizin 2014; 109: 156-161
- 76 Hearnshaw SA, Logan RF, Lowe D. et al. Use of endoscopy for management of acute upper gastrointestinal bleeding in the UK: results of a nationwide audit. Gut 2010; 59: 1022-1029
- 77 Bai Y, Guo JF, Li ZS. Meta-analysis: erythromycin before endoscopy for acute upper gastrointestinal bleeding. Alimentary pharmacology & therapeutics 2011; 34: 166-171
- 78 Szary NM, Gupta R, Choudhary A. et al. Erythromycin prior to endoscopy in acute upper gastrointestinal bleeding: a meta-analysis. Scandinavian journal of gastroenterology 2011; 46: 920-924
- 79 Theivanayagam S, Lim RG, Cobell WJ. et al. Administration of erythromycin before endoscopy in upper gastrointestinal bleeding: a meta-analysis of randomized controlled trials. Saudi journal of gastroenterology: official journal of the Saudi Gastroenterology Association 2013; 19: 205-210
- 80 Winstead NS, Wilcox CM. Erythromycin prior to endoscopy for acute upper gastrointestinal haemorrhage: a cost-effectiveness analysis. Alimentary pharmacology & therapeutics 2007; 26: 1371-1377
- 81 Barkun AN, Bardou M, Kuipers EJ. et al. International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Annals of internal medicine 2010; 152: 101-113
- 82 Koch DG, Arguedas MR, Fallon MB. Risk of aspiration pneumonia in suspected variceal hemorrhage: the value of prophylactic endotracheal intubation prior to endoscopy. Digestive diseases and sciences 2007; 52: 2225-2228
- 83 Rudolph SJ, Landsverk BK, Freeman ML. Endotracheal intubation for airway protection during endoscopy for severe upper GI hemorrhage. Gastrointestinal endoscopy 2003; 57: 58-61
- 84 Rehman A, Iscimen R, Yilmaz M. et al. Prophylactic endotracheal intubation in critically ill patients undergoing endoscopy for upper GI hemorrhage. Gastrointestinal endoscopy 2009; 69: e55-e59
- 85 Hayat U, Lee PJ, Ullah H. et al. Association of prophylactic endotracheal intubation in critically ill patients with upper GI bleeding and cardiopulmonary unplanned events. Gastrointestinal endoscopy 2016; DOI: 10.1016/j.gie.2016.12.008.
- 86 Janssens U, Burchardi H, Duttge G. et al. Change in therapy target and therapy limitations in intensive care medicine. Position paper of the Ethics Section of the German Interdisciplinary Association for Intensive Care and Emergency Medicine. Der Anaesthesist 2013; 62: 47-52
- 87 Denzer U, Beilenhoff U, Eickhoff A. et al. S2k guideline: quality requirements for gastrointestinal endoscopy, AWMF registry no. 021-022, recommendations. Zeitschrift für Gastroenterologie 2015; 53: E1-E227
- 88 Seshasai SR, Wijesuriya S, Sivakumaran R. et al. Effect of aspirin on vascular and nonvascular outcomes: meta-analysis of randomized controlled trials. Arch Intern Med 2012; 172: 209-216
- 89 McQuaid KR, Laine L. Systematic review and meta-analysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trials. The American journal of medicine 2006; 119: 624-638
- 90 Hansen ML, Sorensen R, Clausen MT. et al. Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation. Arch Intern Med 2010; 170: 1433-1441
- 91 Lamberts M, Gislason GH, Lip GY. et al. Antiplatelet therapy for stable coronary artery disease in atrial fibrillation patients taking an oral anticoagulant: a nationwide cohort study. Circulation 2014; 129: 1577-1585
- 92 Lamberts M, Olesen JB, Ruwald MH. et al. Bleeding after initiation of multiple antithrombotic drugs, including triple therapy, in atrial fibrillation patients following myocardial infarction and coronary intervention: a nationwide cohort study. Circulation 2012; 126: 1185-1193
- 93 Kikkert WJ, Hassell ME, Delewi R. et al. Predictors and prognostic consequence of gastrointestinal bleeding in patients with ST-segment elevation myocardial infarction. Int J Cardiol 2015; 184: 128-134
- 94 Cote R, Zhang Y, Hart RG. et al. ASA failure: does the combination ASA/clopidogrel confer better long-term vascular protection?. Neurology 2014; 82: 382-389
- 95 Chen Z, Qian J, Chen Y. et al. Addition of cilostazol to conventional dual antiplatelet therapy reduces the risk of cardiac events and restenosis after drug-eluting stent implantation: a meta-analysis. J Clin Pharmacol 2013; 53: 532-539
- 96 Guerrouij M, Uppal CS, Alklabi A. et al. The clinical impact of bleeding during oral anticoagulant therapy: assessment of morbidity, mortality and post-bleed anticoagulant management. Journal of thrombosis and thrombolysis 2011; 31: 419-423
- 97 Holbrook A, Schulman S, Witt DM. et al. Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141: e152S-e184S
- 98 Rikala M, Kastarinen H, Tiittanen P. et al. Natural history of bleeding and characteristics of early bleeders among warfarin initiators – a cohort study in Finland. Clin Epidemiol 2016; 8: 23-35
- 99 Caldeira D, Barra M, Ferreira A. et al. Systematic review with meta-analysis: the risk of major gastrointestinal bleeding with non-vitamin K antagonist oral anticoagulants. Alimentary pharmacology & therapeutics 2015; 42: 1239-1249
- 100 Gallagher AM, van Staa TP, Murray-Thomas T. et al. Population-based cohort study of warfarin-treated patients with atrial fibrillation: incidence of cardiovascular and bleeding outcomes. BMJ Open 2014; 4: e003839
- 101 Holster IL, Valkhoff VE, Kuipers EJ. et al. New oral anticoagulants increase risk for gastrointestinal bleeding: a systematic review and meta-analysis. Gastroenterology 2013; 145: 105-112 e115
- 102 Leon MB, Baim DS, Popma JJ. et al. A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. Stent Anticoagulation Restenosis Study Investigators. The New England journal of medicine 1998; 339: 1665-1671
- 103 Ng FH, Wong SY, Lam KF. et al. Gastrointestinal bleeding in patients receiving a combination of aspirin, clopidogrel, and enoxaparin in acute coronary syndrome. The American journal of gastroenterology 2008; 103: 865-871
- 104 Dewilde WJ, Oirbans T, Verheugt FW. et al. Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial. Lancet 2013; 381: 1107-1115
- 105 Segal JB, Dzik WH. Transfusion Medicine/Hemostasis Clinical Trials N.. Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: an evidence-based review. Transfusion 2005; 45: 1413-1425
- 106 Davis A, Walsh M, McCarthy P. et al. Tranexamic acid without prophylactic factor replacement for prevention of bleeding in hereditary bleeding disorder patients undergoing endoscopy: a pilot study. Haemophilia 2013; 19: 583-589
- 107 (BÄK). B. Querschnitts-Leitlinien (BÄK) zur Therapie mit Blutkomponenten und Plasmaderivaten. 2014 http://bundesaerztekammerde/downloadsQLL_Haemotherapie_2014pdf
- 108 Srivastava A, Brewer AK, Mauser-Bunschoten EP. et al. Guidelines for the management of hemophilia. Haemophilia 2013; 19: e1-e47
- 109 Denzer U, Beilenhoff U, Eickhoff A. et al. S2k guideline: quality requirements for gastrointestinal endoscopy, AWMF registry no. 021-022. Zeitschrift für Gastroenterologie 2015; 53: E1-E227
- 110 Tripodi A, Caldwell SH, Hoffman M. et al. Review article: the prothrombin time test as a measure of bleeding risk and prognosis in liver disease. Alimentary pharmacology & therapeutics 2007; 26: 141-148
- 111 Tripodi A, Mannucci PM. Abnormalities of hemostasis in chronic liver disease: reappraisal of their clinical significance and need for clinical and laboratory research. Journal of hepatology 2007; 46: 727-733
- 112 Tripodi A, Anstee QM, Sogaard KK. et al. Hypercoagulability in cirrhosis: causes and consequences. Journal of thrombosis and haemostasis: JTH 2011; 9: 1713-1723
- 113 Choudari CP, Rajgopal C, Palmer KR. Acute gastrointestinal haemorrhage in anticoagulated patients: diagnoses and response to endoscopic treatment. Gut 1994; 35: 464-466
- 114 Rubin TA, Murdoch M, Nelson DB. Acute GI bleeding in the setting of supratherapeutic international normalized ratio in patients taking warfarin: endoscopic diagnosis, clinical management, and outcomes. Gastrointestinal endoscopy 2003; 58: 369-373
- 115 Jairath V, Kahan BC, Logan RF. et al. National audit of the use of surgery and radiological embolization after failed endoscopic haemostasis for non-variceal upper gastrointestinal bleeding. The British journal of surgery 2012; 99: 1672-1680
- 116 Lordkipanidze M. Is platelet transfusion the solution to reverse platelet inhibition in patients on triple antiplatelet therapy?. Thrombosis research 2015; 136: 1057-1058
- 117 Bhal V, Herr MJ, Dixon M. et al. Platelet function recovery following exposure to triple anti-platelet inhibitors using an in vitro transfusion model. Thrombosis research 2015; 136: 1216-1223
- 118 Bhatt DL, Scheiman J, Abraham NS. et al. ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. Circulation 2008; 118: 1894-1909
- 119 Acosta RD, Abraham NS. Committee ASoP. et al. The management of antithrombotic agents for patients undergoing GI endoscopy. Gastrointestinal endoscopy 2016; 83: 3-16
- 120 Sung JJ, Lau JY, Ching JY. et al. Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial. Annals of internal medicine 2010; 152: 1-9
- 121 Biondi-Zoccai GG, Lotrionte M, Agostoni P. et al. A systematic review and meta-analysis on the hazards of discontinuing or not adhering to aspirin among 50,279 patients at risk for coronary artery disease. European heart journal 2006; 27: 2667-2674
- 122 Burger W, Chemnitius JM, Kneissl GD. et al. Low-dose aspirin for secondary cardiovascular prevention – cardiovascular risks after its perioperative withdrawal versus bleeding risks with its continuation – review and meta-analysis. J Intern Med 2005; 257: 399-414
- 123 Witt DM, Delate T, Garcia DA. et al. Risk of thromboembolism, recurrent hemorrhage, and death after warfarin therapy interruption for gastrointestinal tract bleeding. Arch Intern Med 2012; 172: 1484-1491
- 124 Qureshi W, Mittal C, Patsias I. et al. Restarting anticoagulation and outcomes after major gastrointestinal bleeding in atrial fibrillation. Am J Cardiol 2014; 113: 662-668
- 125 Sengupta N, Feuerstein JD, Patwardhan VR. et al. The risks of thromboembolism vs. recurrent gastrointestinal bleeding after interruption of systemic anticoagulation in hospitalized inpatients with gastrointestinal bleeding: a prospective study. The American journal of gastroenterology 2015; 110: 328-335
- 126 Radaelli F, Paggi S, Terruzzi V. et al. Management of warfarin-associated coagulopathy in patients with acute gastrointestinal bleeding: a cross-sectional physician survey of current practice. Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2011; 43: 444-447
- 127 Roudaut R, Serri K, Lafitte S. Thrombosis of prosthetic heart valves: diagnosis and therapeutic considerations. Heart 2007; 93: 137-142
- 128 Maulaz AB, Bezerra DC, Michel P. et al. Effect of discontinuing aspirin therapy on the risk of brain ischemic stroke. Arch Neurol 2005; 62: 1217-1220
- 129 Wolf AT, Wasan SK, Saltzman JR. Impact of anticoagulation on rebleeding following endoscopic therapy for nonvariceal upper gastrointestinal hemorrhage. The American journal of gastroenterology 2007; 102: 290-296
- 130 Skaistis J, Tagami T. Risk of Fatal Bleeding in Episodes of Major Bleeding with New Oral Anticoagulants and Vitamin K Antagonists: A Systematic Review and Meta-Analysis. PloS one 2015; 10: e0137444
- 131 Sartori MT, Prandoni P. How to effectively manage the event of bleeding complications when using anticoagulants. Expert Rev Hematol 2016; 9: 37-50
- 132 Marlu R, Hodaj E, Paris A. et al. Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers. Thrombosis and haemostasis 2012; 108: 217-224
- 133 Farrell JJ, Friedman LS. Review article: the management of lower gastrointestinal bleeding. Alimentary pharmacology & therapeutics 2005; 21: 1281-1298
- 134 Laine L, Shah A. Randomized trial of urgent vs. elective colonoscopy in patients hospitalized with lower GI bleeding. The American journal of gastroenterology 2010; 105: 2636-2641 ; quiz 2642
- 135 Ohyama T, Sakurai Y, Ito M. et al. Analysis of urgent colonoscopy for lower gastrointestinal tract bleeding. Digestion 2000; 61: 189-192
- 136 Jensen DM, Machicado GA, Jutabha R. et al. Urgent colonoscopy for the diagnosis and treatment of severe diverticular hemorrhage. The New England journal of medicine 2000; 342: 78-82
- 137 Mizuki A, Tatemichi M, Hatogai K. et al. Timely colonoscopy leads to faster identification of bleeding diverticulum. Nihon Shokakibyo Gakkai Zasshi 2013; 110: 1927-1933
- 138 Yamada A, Niikura R, Yoshida S. et al. Endoscopic management of colonic diverticular bleeding. Dig Endosc 2015; 27: 720-725
- 139 Green BT, Rockey DC, Portwood G. et al. Urgent colonoscopy for evaluation and management of acute lower gastrointestinal hemorrhage: a randomized controlled trial. The American journal of gastroenterology 2005; 100: 2395-2402
- 140 Niikura R, Nagata N, Aoki T. et al. Predictors for identification of stigmata of recent hemorrhage on colonic diverticula in lower gastrointestinal bleeding. Journal of clinical gastroenterology 2015; 49: e24-e30
- 141 Angtuaco TL, Reddy SK, Drapkin S. et al. The utility of urgent colonoscopy in the evaluation of acute lower gastrointestinal tract bleeding: a 2-year experience from a single center. The American journal of gastroenterology 2001; 96: 1782-1785
- 142 Adamopoulos AB, Baibas NM, Efstathiou SP. et al. Differentiation between patients with acute upper gastrointestinal bleeding who need early urgent upper gastrointestinal endoscopy and those who do not. A prospective study. European journal of gastroenterology & hepatology 2003; 15: 381-387
- 143 Bjorkman DJ, Zaman A, Fennerty MB. et al. Urgent vs. elective endoscopy for acute non-variceal upper-GI bleeding: an effectiveness study. Gastrointestinal endoscopy 2004; 60: 1-8
- 144 Lee JG, Turnipseed S, Romano PS. et al. Endoscopy-based triage significantly reduces hospitalization rates and costs of treating upper GI bleeding: a randomized controlled trial. Gastrointestinal endoscopy 1999; 50: 755-761
- 145 Wysocki JD, Srivastav S, Winstead NS. A nationwide analysis of risk factors for mortality and time to endoscopy in upper gastrointestinal haemorrhage. Alimentary pharmacology & therapeutics 2012; 36: 30-36
- 146 Tohda G, Higashi S, Sakumoto H. et al. Efficacy and safety of nurse-administered propofol sedation during emergency upper endoscopy for gastrointestinal bleeding: a prospective study. Endoscopy 2006; 38: 684-689
- 147 Park CH, Han DS, Jeong JY. et al. Outcomes of Propofol Sedation During Emergency Endoscopy Performed for Upper Gastrointestinal Bleeding. Digestive diseases and sciences 2016; 61: 825-834
- 148 Yoon W, Jeong YY, Shin SS. et al. Acute massive gastrointestinal bleeding: detection and localization with arterial phase multi-detector row helical CT. Radiology 2006; 239: 160-167
- 149 Scheffel H, Pfammatter T, Wildi S. et al. Acute gastrointestinal bleeding: detection of source and etiology with multi-detector-row CT. European radiology 2007; 17: 1555-1565
- 150 Jaeckle T, Stuber G, Hoffmann MH. et al. Detection and localization of acute upper and lower gastrointestinal (GI) bleeding with arterial phase multi-detector row helical CT. European radiology 2008; 18: 1406-1413
- 151 Frattaroli FM, Casciani E, Spoletini D. et al. Prospective study comparing multi-detector row CT and endoscopy in acute gastrointestinal bleeding. World J Surg 2009; 33: 2209-2217
- 152 Kuhle WG, Sheiman RG. Detection of active colonic hemorrhage with use of helical CT: findings in a swine model. Radiology 2003; 228: 743-752
- 153 Dobritz M, Engels HP, Schneider A. et al. Evaluation of dual-phase multi-detector-row CT for detection of intestinal bleeding using an experimental bowel model. European radiology 2009; 19: 875-881
- 154 Chua AE, Ridley LJ. Diagnostic accuracy of CT angiography in acute gastrointestinal bleeding. J Med Imaging Radiat Oncol 2008; 52: 333-338
- 155 Wu LM, Xu JR, Yin Y. et al. Usefulness of CT angiography in diagnosing acute gastrointestinal bleeding: a meta-analysis. World journal of gastroenterology: WJG 2010; 16: 3957-3963
- 156 Garcia-Blazquez V, Vicente-Bartulos A, Olavarria-Delgado A. et al. Accuracy of CT angiography in the diagnosis of acute gastrointestinal bleeding: systematic review and meta-analysis. European radiology 2013; 23: 1181-1190
- 157 Artigas JM, Marti M, Soto JA. et al. Multidetector CT angiography for acute gastrointestinal bleeding: technique and findings. Radiographics 2013; 33: 1453-1470
- 158 Geffroy Y, Rodallec MH, Boulay-Coletta I. et al. Multidetector CT angiography in acute gastrointestinal bleeding: why, when, and how. Radiographics 2011; 31: E35-E46
- 159 Stuber T, Hoffmann MH, Stuber G. et al. Pitfalls in detection of acute gastrointestinal bleeding with multi-detector row helical CT. Abdom Imaging 2009; 34: 476-482
- 160 Kennedy DW, Laing CJ, Tseng LH. et al. Detection of active gastrointestinal hemorrhage with CT angiography: a 4(1/2)-year retrospective review. Journal of vascular and interventional radiology: JVIR 2010; 21: 848-855
- 161 Fisher L, Lee Krinsky M. Committee ASoP. et al. The role of endoscopy in the management of obscure GI bleeding. Gastrointestinal endoscopy 2010; 72: 471-479
- 162 Bresci G, Parisi G, Bertoni M. et al. The role of video capsule endoscopy for evaluating obscure gastrointestinal bleeding: usefulness of early use. Journal of gastroenterology 2005; 40: 256-259
- 163 Singh A, Marshall C, Chaudhuri B. et al. Timing of video capsule endoscopy relative to overt obscure GI bleeding: implications from a retrospective study. Gastrointestinal endoscopy 2013; 77: 761-766
- 164 Gilbert D, O'Malley S, Selby W. Are repeat upper gastrointestinal endoscopy and colonoscopy necessary within six months of capsule endoscopy in patients with obscure gastrointestinal bleeding?. Journal of gastroenterology and hepatology 2008; 23: 1806-1809
- 165 Leaper M, Johnston MJ, Barclay M. et al. Reasons for failure to diagnose colorectal carcinoma at colonoscopy. Endoscopy 2004; 36: 499-503
- 166 Pennazio M, Spada C, Eliakim R. et al. Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy 2015; 47: 352-376
- 167 Berkelhammer C, Radvany A, Lin A. et al. Heparin provocation for endoscopic localization of recurrent obscure GI hemorrhage. Gastrointestinal endoscopy 2000; 52: 555-556
- 168 Raines DL, Jex KT, Nicaud MJ. et al. Pharmacologic provocation combined with endoscopy in refractory cases of GI bleeding. Gastrointestinal endoscopy 2017; 85: 112-120
- 169 de Leusse A, Vahedi K, Edery J. et al. Capsule endoscopy or push enteroscopy for first-line exploration of obscure gastrointestinal bleeding?. Gastroenterology 2007; 132: 855-862 ; quiz 1164–1165
- 170 Lepileur L, Dray X, Antonietti M. et al. Factors associated with diagnosis of obscure gastrointestinal bleeding by video capsule enteroscopy. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 2012; 10: 1376-1380
- 171 Bandorski D, Irnich W, Bruck M. et al. Do endoscopy capsules interfere with implantable cardioverter-defibrillators?. Endoscopy 2009; 41: 457-461
- 172 Herrerias JM, Leighton JA, Costamagna G. et al. Agile patency system eliminates risk of capsule retention in patients with known intestinal strictures who undergo capsule endoscopy. Gastrointestinal endoscopy 2008; 67: 902-909
- 173 May A, Albert J, Keuchel M. et al. Capsule endoscopy for the diagnosis of small bowel diseases. An updated statement by the endoscopy section of DGVS. Zeitschrift fur Gastroenterologie 2010; 48: 1384-1404
- 174 Spada C, Riccioni ME, Costamagna G. The new, dissolving patency capsule: a safe and effective tool to avoid the complication of retained video capsules. Journal of clinical gastroenterology 2008; 42: 761-762
- 175 Macdonald J, Porter V, McNamara D. Negative capsule endoscopy in patients with obscure GI bleeding predicts low rebleeding rates. Gastrointestinal endoscopy 2008; 68: 1122-1127
- 176 Min YW, Kim JS, Jeon SW. et al. Long-term outcome of capsule endoscopy in obscure gastrointestinal bleeding: a nationwide analysis. Endoscopy 2014; 46: 59-65
- 177 Tanizawa Y, Bando E, Kawamura T. et al. Early postoperative anastomotic hemorrhage after gastrectomy for gastric cancer. Gastric Cancer 2010; 13: 50-57
- 178 Abell TL, Minocha A. Gastrointestinal complications of bariatric surgery: diagnosis and therapy. Am J Med Sci 2006; 331: 214-218
- 179 Malik AH, East JE, Buchanan GN. et al. Endoscopic haemostasis of staple-line haemorrhage following colorectal resection. Colorectal disease: the official journal of the Association of Coloproctology of Great Britain and Ireland 2008; 10: 616-618
- 180 Martinez-Serrano MA, Pares D, Pera M. et al. Management of lower gastrointestinal bleeding after colorectal resection and stapled anastomosis. Tech Coloproctol 2009; 13: 49-53
- 181 Cirocco WC, Golub RW. Endoscopic treatment of postoperative hemorrhage from a stapled colorectal anastomosis. Am Surg 1995; 61: 460-463
- 182 Linn TY, Moran BJ, Cecil TD. Staple line haemorrhage following laparoscopic left-sided colorectal resections may be more common when the inferior mesenteric artery is preserved. Tech Coloproctol 2008; 12: 289-293
- 183 Beyer L, Bonmardion R, Marciano S. et al. Results of non-operative therapy for delayed hemorrhage after pancreaticoduodenectomy. Journal of gastrointestinal surgery: official journal of the Society for Surgery of the Alimentary Tract 2009; 13: 922-928
- 184 Yekebas EF, Wolfram L, Cataldegirmen G. et al. Postpancreatectomy hemorrhage: diagnosis and treatment: an analysis in 1669 consecutive pancreatic resections. Annals of surgery 2007; 246: 269-280
- 185 Vernadakis S, Christodoulou E, Treckmann J. et al. Pseudoaneurysmal rupture of the common hepatic artery into the biliodigestive anastomosis. A rare cause of gastrointestinal bleeding. JOP 2009; 10: 441-444
- 186 Andersson B, Nilsson J, Brandt J. et al. Gastrointestinal complications after cardiac surgery. The British journal of surgery 2005; 92: 326-333
- 187 Sakorafas GH, Tsiotos GG. Intra-abdominal complications after cardiac surgery. Eur J Surg 1999; 165: 820-827
- 188 Valentine RJ, Hagino RT, Jackson MR. et al. Gastrointestinal complications after aortic surgery. Journal of vascular surgery 1998; 28: 404-411 ; discussion 411–402
- 189 Baril DT, Carroccio A, Ellozy SH. et al. Evolving strategies for the treatment of aortoenteric fistulas. Journal of vascular surgery 2006; 44: 250-257
- 190 Peck JJ, Eidemiller LR. Aortoenteric fistulas. Arch Surg 1992; 127: 1191-1193 ; discussion 1193–1194
- 191 Hiramoto JS, Terdiman JP, Norton JA. Evidence-based analysis: postoperative gastric bleeding: etiology and prevention. Surg Oncol 2003; 12: 9-19
- 192 Cook DJ, Fuller HD, Guyatt GH. et al. Risk factors for gastrointestinal bleeding in critically ill patients. Canadian Critical Care Trials Group. The New England journal of medicine 1994; 330: 377-381
- 193 Forrest JA, Finlayson ND, Shearman DJ. Endoscopy in gastrointestinal bleeding. Lancet 1974; 2: 394-397
- 194 de Groot NL, van Oijen MG, Kessels K. et al. Reassessment of the predictive value of the Forrest classification for peptic ulcer rebleeding and mortality: can classification be simplified?. Endoscopy 2014; 46: 46-52
- 195 Elmunzer BJ, Young SD, Inadomi JM. et al. Systematic review of the predictors of recurrent hemorrhage after endoscopic hemostatic therapy for bleeding peptic ulcers. The American journal of gastroenterology 2008; 103: 2625-2632 ; quiz 2633
- 196 Bour B, Person B, Cales P. et al. Interobserver agreement on endoscopic diagnosis of bleeding peptic ulcers. Gastrointestinal endoscopy 1997; 46: 27-32
- 197 Lau JY, Sung JJ, Chan AC. et al. Stigmata of hemorrhage in bleeding peptic ulcers: an interobserver agreement study among international experts. Gastrointestinal endoscopy 1997; 46: 33-36
- 198 Mondardini A, Barletti C, Rocca G. et al. Non-variceal upper gastrointestinal bleeding and Forrest's classification: diagnostic agreement between endoscopists from the same area. Endoscopy 1998; 30: 508-512
- 199 Laine L, McQuaid KR. Endoscopic therapy for bleeding ulcers: an evidence-based approach based on meta-analyses of randomized controlled trials. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 2009; 7: 33-47
- 200 Lin HJ, Wang K, Perng CL. et al. Natural history of bleeding peptic ulcers with a tightly adherent blood clot: a prospective observation. Gastrointestinal endoscopy 1996; 43: 470-473
- 201 Bleau BL, Gostout CJ, Sherman KE. et al. Recurrent bleeding from peptic ulcer associated with adherent clot: a randomized study comparing endoscopic treatment with medical therapy. Gastrointestinal endoscopy 2002; 56: 1-6
- 202 Jensen DM, Kovacs TO, Jutabha R. et al. Randomized trial of medical or endoscopic therapy to prevent recurrent ulcer hemorrhage in patients with adherent clots. Gastroenterology 2002; 123: 407-413
- 203 Kahi CJ, Jensen DM, Sung JJ. et al. Endoscopic therapy versus medical therapy for bleeding peptic ulcer with adherent clot: a meta-analysis. Gastroenterology 2005; 129: 855-862
- 204 Petersen B, Barkun A, Carpenter S. et al. Tissue adhesives and fibrin glues. Gastrointestinal endoscopy 2004; 60: 327-333
- 205 Kato M, Jung Y, Gromski MA. et al. Prospective, randomized comparison of 3 different hemoclips for the treatment of acute upper GI hemorrhage in an established experimental setting. Gastrointestinal endoscopy 2012; 75: 3-10
- 206 Chan SM, Chiu PW, Teoh AY. et al. Use of the Over-The-Scope Clip for treatment of refractory upper gastrointestinal bleeding: a case series. Endoscopy 2014; 46: 428-431
- 207 Manno M, Mangiafico S, Caruso A. et al. First-line endoscopic treatment with OTSC in patients with high-risk non-variceal upper gastrointestinal bleeding: preliminary experience in 40 cases. Surg Endosc 2016; 30: 2026-2029
- 208 Skinner M, Gutierrez JP, Neumann H. et al. Over-the-scope clip placement is effective rescue therapy for severe acute upper gastrointestinal bleeding. Endosc Int Open 2014; 2: E37-E40
- 209 Barkun AN, Martel M, Toubouti Y. et al. Endoscopic hemostasis in peptic ulcer bleeding for patients with high-risk lesions: a series of meta-analyses. Gastrointestinal endoscopy 2009; 69: 786-799
- 210 Marmo R, Rotondano G, Piscopo R. et al. Dual therapy versus monotherapy in the endoscopic treatment of high-risk bleeding ulcers: a meta-analysis of controlled trials. The American journal of gastroenterology 2007; 102: 279-289 ; quiz 469
- 211 Sung JJ, Tsoi KK, Lai LH. et al. Endoscopic clipping versus injection and thermo-coagulation in the treatment of non-variceal upper gastrointestinal bleeding: a meta-analysis. Gut 2007; 56: 1364-1373
- 212 Vergara M, Bennett C, Calvet X. et al. Epinephrine injection versus epinephrine injection and a second endoscopic method in high-risk bleeding ulcers. The Cochrane database of systematic reviews 2014; DOI: 10.1002/14651858.CD005584.pub3:CD005584.
- 213 Holster IL, van Beusekom HM, Kuipers EJ. et al. Effects of a hemostatic powder hemospray on coagulation and clot formation. Endoscopy 2015; 47: 638-645
- 214 Masci E, Arena M, Morandi E. et al. Upper gastrointestinal active bleeding ulcers: review of literature on the results of endoscopic techniques and our experience with Hemospray. Scandinavian journal of gastroenterology 2014; 49: 1290-1295
- 215 Smith LA, Stanley AJ, Bergman JJ. et al. Hemospray application in nonvariceal upper gastrointestinal bleeding: results of the Survey to Evaluate the Application of Hemospray in the Luminal Tract. Journal of clinical gastroenterology 2014; 48: e89-e92
- 216 Chen YI, Barkun A, Nolan S. Hemostatic powder TC-325 in the management of upper and lower gastrointestinal bleeding: a two-year experience at a single institution. Endoscopy 2015; 47: 167-171
- 217 Beg S, Al-Bakir I, Bhuva M. et al. Early clinical experience of the safety and efficacy of EndoClot in the management of non-variceal upper gastrointestinal bleeding. Endosc Int Open 2015; 3: E605-E609
- 218 Prei JC, Barmeyer C, Burgel N. et al. EndoClot Polysaccharide Hemostatic System in Nonvariceal Gastrointestinal Bleeding: Results of a Prospective Multicenter Observational Pilot Study. Journal of clinical gastroenterology 2016; 50: e95-e100
- 219 Ferlitsch A, Puspok A, Bota S. et al. Efficacy and safety of bovine activated factors IIa/VIIa/IXa/Xa in patients with active gastrointestinal bleeding: a proof of concept study. Endoscopy 2016; 48: 380-384
- 220 Yoshida M, Goto N, Kawaguchi M. et al. Initial clinical trial of a novel hemostat, TDM-621, in the endoscopic treatments of the gastric tumors. Journal of gastroenterology and hepatology 2014; 29 (Suppl. 04) 77-79
- 221 Huang SP, Wang HP, Lee YC. et al. Endoscopic hemoclip placement and epinephrine injection for Mallory-Weiss syndrome with active bleeding. Gastrointestinal endoscopy 2002; 55: 842-846
- 222 Llach J, Elizalde JI, Guevara MC. et al. Endoscopic injection therapy in bleeding Mallory-Weiss syndrome: a randomized controlled trial. Gastrointestinal endoscopy 2001; 54: 679-681
- 223 Yamaguchi Y, Yamato T, Katsumi N. et al. Endoscopic hemoclipping for upper GI bleeding due to Mallory-Weiss syndrome. Gastrointestinal endoscopy 2001; 53: 427-430
- 224 Cho YS, Chae HS, Kim HK. et al. Endoscopic band ligation and endoscopic hemoclip placement for patients with Mallory-Weiss syndrome and active bleeding. World journal of gastroenterology: WJG 2008; 14: 2080-2084
- 225 Swanson E, Mahgoub A, MacDonald R. et al. Medical and endoscopic therapies for angiodysplasia and gastric antral vascular ectasia: a systematic review. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 2014; 12: 571-582
- 226 Dray X, Repici A, Gonzalez P. et al. Radiofrequency ablation for the treatment of gastric antral vascular ectasia. Endoscopy 2014; 46: 963-969
- 227 Gross SA, Al-Haddad M, Gill KR. et al. Endoscopic mucosal ablation for the treatment of gastric antral vascular ectasia with the HALO90 system: a pilot study. Gastrointestinal endoscopy 2008; 67: 324-327
- 228 Jana T, Thosani N, Fallon MB. et al. Radiofrequency ablation for treatment of refractory gastric antral vascular ectasia (with video). Endosc Int Open 2015; 3: E125-E127
- 229 Park CH, Sohn YH, Lee WS. et al. The usefulness of endoscopic hemoclipping for bleeding Dieulafoy lesions. Endoscopy 2003; 35: 388-392
- 230 Gomez V, Kyanam Kabir Baig KR, Lukens FJ. et al. Novel treatment of a gastric Dieulafoy lesion with an over-the-scope clip. Endoscopy 2013; 45 (Suppl. 02) E71
- 231 Alis H, Oner OZ, Kalayci MU. et al. Is endoscopic band ligation superior to injection therapy for Dieulafoy lesion?. Surg Endosc 2009; 23: 1465-1469
- 232 Karamanolis G, Triantafyllou K, Tsiamoulos Z. et al. Argon plasma coagulation has a long-lasting therapeutic effect in patients with chronic radiation proctitis. Endoscopy 2009; 41: 529-531
- 233 Alvaro-Villegas JC, Sobrino-Cossio S, Tenorio-Tellez LC. et al. Argon plasma coagulation and hyperbaric oxygen therapy in chronic radiation proctopathy, effectiveness and impact on tissue toxicity. Rev Esp Enferm Dig 2011; 103: 576-581
- 234 Lenz L, Tafarel J, Correia L. et al. Comparative study of bipolar eletrocoagulation versus argon plasma coagulation for rectal bleeding due to chronic radiation coloproctopathy. Endoscopy 2011; 43: 697-701
- 235 Akhtar K, Byrne JP, Bancewicz J. et al. Argon beam plasma coagulation in the management of cancers of the esophagus and stomach. Surg Endosc 2000; 14: 1127-1130
- 236 Johnston JH, Fleischer D, Petrini J. et al. Palliative bipolar electrocoagulation therapy of obstructing esophageal cancer. Gastrointestinal endoscopy 1987; 33: 349-353
- 237 Mambrini P, Audibert P, Barthet M. et al. Palliative treatment of esophageal neoplastic stenosis using bipolar electrocoagulation probe. Gastroenterologie clinique et biologique 1996; 20: 844-851
- 238 Kofoed SC, Lundsgaard M, Ellemann AC. et al. Low morbidity after palliation of obstructing gastro-oesophageal adenocarcinoma to restore swallowing function. Dan Med J 2012; 59: A4434
- 239 Kok KY, Kum CK, Goh PM. Colonoscopic evaluation of severe hematochezia in an Oriental population. Endoscopy 1998; 30: 675-680
- 240 Poncet G, Heluwaert F, Voirin D. et al. Natural history of acute colonic diverticular bleeding: a prospective study in 133 consecutive patients. Alimentary pharmacology & therapeutics 2010; 32: 466-471
- 241 Kaltenbach T, Watson R, Shah J. et al. Colonoscopy with clipping is useful in the diagnosis and treatment of diverticular bleeding. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 2012; 10: 131-137
- 242 Ishii N, Setoyama T, Deshpande GA. et al. Endoscopic band ligation for colonic diverticular hemorrhage. Gastrointestinal endoscopy 2012; 75: 382-387
- 243 Oda I, Suzuki H, Nonaka S. et al. Complications of gastric endoscopic submucosal dissection. Dig Endosc 2013; 25 (Suppl. 01) 71-78
- 244 Fahrtash-Bahin F, Holt BA, Jayasekeran V. et al. Snare tip soft coagulation achieves effective and safe endoscopic hemostasis during wide-field endoscopic resection of large colonic lesions (with videos). Gastrointestinal endoscopy 2013; 78: 158-163 e151
- 245 Burgess NG, Metz AJ, Williams SJ. et al. Risk factors for intraprocedural and clinically significant delayed bleeding after wide-field endoscopic mucosal resection of large colonic lesions. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association 2014; 12: 651-661 e651–653
- 246 Curcio G, Granata A, Traina M. Hemospray for multifocal bleeding following ultra-low rectal endoscopic submucosal dissection. Dig Endosc 2014; 26: 606-607
- 247 Tsuji Y, Fujishiro M, Kodashima S. et al. Polyglycolic acid sheets and fibrin glue decrease the risk of bleeding after endoscopic submucosal dissection of gastric neoplasms (with video). Gastrointestinal endoscopy 2015; 81: 906-912
- 248 Alcaide N, Penas-Herrero I, Sancho-del-Val L. et al. Ovesco system for treatment of postpolypectomy bleeding after failure of conventional treatment. Rev Esp Enferm Dig 2014; 106: 55-58
- 249 Schmidt A, Gölder S, Messmann H. et al. Over-the-scope-clips versus standard endoscopic therapy in patients with recurrent peptic ulcer bleeding – a prospective randomized, multicenter trial (STING). United European Gastroenterology Journal; 2016: 2 (Supplement 1)
- 250 Sulz MC, Frei R, Meyenberger C. et al. Routine use of Hemospray for gastrointestinal bleeding: prospective two-center experience in Switzerland. Endoscopy 2014; 46: 619-624
- 251 Smith LA, Morris AJ, Stanley AJ. The use of hemospray in portal hypertensive bleeding; a case series. Journal of hepatology 2014; 60: 457-460
- 252 Strate LL, Gralnek IM. ACG Clinical Guideline: Management of Patients With Acute Lower Gastrointestinal Bleeding. The American journal of gastroenterology 2016; 111: 459-474
- 253 Levy MJ, Wong Kee Song LM, Farnell MB. et al. Endoscopic ultrasound (EUS)-guided angiotherapy of refractory gastrointestinal bleeding. The American journal of gastroenterology 2008; 103: 352-359
- 254 Holster IL, Kuipers EJ. Management of acute nonvariceal upper gastrointestinal bleeding: current policies and future perspectives. World journal of gastroenterology: WJG 2012; 18: 1202-1207
- 255 Sbrozzi-Vanni A, Zullo A, Di Giulio E. et al. Low prevalence of idiopathic peptic ulcer disease: an Italian endoscopic survey. Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2010; 42: 773-776
- 256 Gisbert JP, Abraira V. Accuracy of Helicobacter pylori diagnostic tests in patients with bleeding peptic ulcer: a systematic review and meta-analysis. The American journal of gastroenterology 2006; 101: 848-863
- 257 Sanchez-Delgado J, Gene E, Suarez D. et al. Has H. pylori prevalence in bleeding peptic ulcer been underestimated? A meta-regression. The American journal of gastroenterology 2011; 106: 398-405
- 258 Kyaw M, Tse Y, Ang D. et al. Embolization versus surgery for peptic ulcer bleeding after failed endoscopic hemostasis: a meta-analysis. Endosc Int Open 2014; 2: E6-E14
- 259 Beggs AD, Dilworth MP, Powell SL. et al. A systematic review of transarterial embolization versus emergency surgery in treatment of major nonvariceal upper gastrointestinal bleeding. Clin Exp Gastroenterol 2014; 7: 93-104
- 260 Khanna A, Ognibene SJ, Koniaris LG. Embolization as first-line therapy for diverticulosis-related massive lower gastrointestinal bleeding: evidence from a meta-analysis. Journal of gastrointestinal surgery: official journal of the Society for Surgery of the Alimentary Tract 2005; 9: 343-352
- 261 Padia SA, Geisinger MA, Newman JS. et al. Effectiveness of coil embolization in angiographically detectable versus non-detectable sources of upper gastrointestinal hemorrhage. Journal of vascular and interventional radiology: JVIR 2009; 20: 461-466
- 262 Nanavati SM. What if endoscopic hemostasis fails? Alternative treatment strategies: interventional radiology. Gastroenterology clinics of North America 2014; 43: 739-752
- 263 Farner R, Lichliter W, Kuhn J. et al. Total colectomy versus limited colonic resection for acute lower gastrointestinal bleeding. American journal of surgery 1999; 178: 587-591
- 264 Chiu PW, Lau JY. What if endoscopic hemostasis fails?: Alternative treatment strategies: surgery. Gastroenterology clinics of North America 2014; 43: 753-763
- 265 Ripoll C, Banares R, Beceiro I. et al. Comparison of transcatheter arterial embolization and surgery for treatment of bleeding peptic ulcer after endoscopic treatment failure. Journal of vascular and interventional radiology: JVIR 2004; 15: 447-450
- 266 Wong TC, Wong KT, Chiu PW. et al. A comparison of angiographic embolization with surgery after failed endoscopic hemostasis to bleeding peptic ulcers. Gastrointestinal endoscopy 2011; 73: 900-908
- 267 Morris DL, Hawker PC, Brearley S. et al. Optimal timing of operation for bleeding peptic ulcer: prospective randomised trial. Br Med J (Clin Res Ed) 1984; 288: 1277-1280
- 268 de Franchis R, Faculty BV. Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension. Journal of hepatology 2015; 63: 743-752
- 269 D´Amico G, Pasta L, Morabito A. et al. Competing risks and prognostic stages of cirrhosis: a 25-year inception cohort study of 494 patients. Alimentary Pharmacology & Therapeutics 2014; 39: 1180-1193
- 270 Dhiman RK, Saraswat VA, Choudhuri G. et al. Endosonographic, endoscopic, and histologic evaluation of alterations in the rectal venous system in patients with portal hypertension. Gastrointestinal endoscopy 1999; 49: 218-227
- 271 Ghoshal UC, Biswas PK, Roy G. et al. Colonic mucosal changes in portal hypertension. Tropical gastroenterology: official journal of the Digestive Diseases Foundation 2001; 22: 25-27
- 272 Chen LS, Lin HC, Lee FY. et al. Portal hypertensive colopathy in patients with cirrhosis. Scandinavian journal of gastroenterology 1996; 31: 490-494
- 273 Almadi MA, Almessabi A, Wong P. et al. Ectopic varices. Gastrointestinal endoscopy 2011; 74: 380-388
- 274 Fontana RJ, Sanyal AJ, Mehta S. et al. Portal hypertensive gastropathy in chronic hepatitis C patients with bridging fibrosis and compensated cirrhosis: results from the HALT-C trial. The American journal of gastroenterology 2006; 101: 983-992
- 275 Maurice JB, Brodkin E, Arnold F. et al. Validation of the Baveno VI criteria to identify low risk cirrhotic patients not requiring endoscopic surveillance for varices. Journal of hepatology 2016; 65: 899-905
- 276 Abraldes JG, Bureau C, Stefanescu H. et al. Noninvasive tools and risk of clinically significant portal hypertension and varices in compensated cirrhosis: The "Anticipate" study. Hepatology 2016; 64: 2173-2184
- 277 Garcia-Tsao G, Sanyal AJ, Grace ND. et al. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. 2007; 922-938
- 278 Groszmann RJ, Garcia-Tsao G, Bosch J. et al. Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis. New England Journal of Medicine 2005; 353: 2254-2261
- 279 Qi XS, Bao YX, Bai M. et al. Nonselective beta-blockers in cirrhotic patients with no or small varices: A meta-analysis. World Journal of Gastroenterology 2015; 21: 3100-3108
- 280 Bhardwaj A, Kedarisetty CK, Vashishtha C. et al. Carvedilol delays the progression of small oesophageal varices in patients with cirrhosis: a randomised placebo-controlled trial. Gut 2016; DOI: 10.1136/gutjnl-2016-311735: gutjnl-2016-311735.
- 281 Mandorfer M, Peck-Radosavljevic M, Reiberger T. Prevention of progression from small to large varices: are we there yet? An updated meta-analysis. Gut 2016; DOI: 10.1136/gutjnl-2016-312814: gutjnl-2016-312814-312813.
- 282 de Franchis R. Faculty ObotBV. Revising consensus in portal hypertension: Report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. Journal of hepatology 2010; 53: 762-768
- 283 Gluud LL, Krag A. Banding ligation versus beta-blockers for primary prevention in oesophageal varices in adults. The Cochrane database of systematic reviews 2012; 8 DOI: CD004544.
- 284 Hayes PC, Davis JM, Lewis JA. et al. Meta-analysis of value of propranolol in prevention of variceal haemorrhage. The Lancet 1990; 336: 153-156
- 285 Tripathi D, Ferguson JW, Kochar N. et al. Randomized controlled trial of carvedilol versus variceal band ligation for the prevention of the first variceal bleed. Hepatology 2009; 50: 825-833
- 286 Cheng JW, Zhu L, Gu MJ. et al. Meta analysis of propranolol effects on gastrointestinal hemorrhage in cirrhotic patients. World Journal of Gastroenterology 2003; 9: 1836-1839
- 287 Banares R, Moitinho E, Matilla A. et al. Randomized comparison of long-term carvedilol and propranolol administration in the treatment of portal hypertension in cirrhosis. Hepatology 2002; 36: 1367-1373
- 288 Sinagra E, Perricone G, D'Amico M. et al. Systematic review with meta-analysis: the haemodynamic effects of carvedilol compared with propranolol for portal hypertension in cirrhosis. Alimentary Pharmacology Therapeutics 2014; 39: 557-568
- 289 Reiberger T, Ulbrich G, Ferlitsch A. et al. Carvedilol for primary prophylaxis of variceal bleeding in cirrhotic patients with haemodynamic non-response to propranolol. Gut 2013; 62: 1634-1641
- 290 Serste T, Melot C, Francoz C. et al. Deleterious effects of beta-blockers on survival in patients with cirrhosis and refractory ascites. Hepatology 2010; 52: 1017-1022
- 291 Leithead JA, Rajoriya N, Tehami N. et al. Non-selective β-blockers are associated with improved survival in patients with ascites listed for liver transplantation. Gut 2015; 64: 1111-1119
- 292 Mookerjee RP, Pavesi M, Thomsen KL. et al. Treatment with non-selective beta blockers is associated with reduced severity of systemic inflammation and improved survival of patients with acute-on-chronic liver failure. Journal of hepatology 2016; 64: 574-582
- 293 Villanueva C, Aracil C, Colomo A. et al. Acute hemodynamic response to beta-blockers and prediction of long-term outcome in primary prophylaxis of variceal bleeding. Gastroenterology 2009; 137: 119-128
- 294 Schepke M, Kleber G, Nürnberg D. et al. Ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology 2004; 40: 65-72
- 295 Imperiale TF, Chalasani N. A meta-analysis of endoscopic variceal ligation for primary prophylaxis of esophageal variceal bleeding. Hepatology 2001; 33: 802-807
- 296 Shah HA, Azam Z, Rauf J. et al. Carvedilol vs. esophageal variceal band ligation in the primary prophylaxis of variceal hemorrhage: a multicentre randomized controlled trial. Journal of hepatology 2014; 60: 757-764
- 297 Lo GH, Chen WC, Wang HM. et al. Controlled trial of ligation plus nadolol versus nadolol alone for the prevention of first variceal bleeding. Hepatology 2010; 52: 230-237
- 298 Tripathi D, Macnicholas R, Kothari C. et al. Good clinical outcomes following transjugular intrahepatic portosystemic stent-shunts in Budd-Chiari syndrome. Alimentary Pharmacology & Therapeutics 2014; 39: 864-872
- 299 Thanapirom K, Ridtitid W, Rerknimitr R. et al. Prospective comparison of three risk scoring systems in non-variceal and variceal upper gastrointestinal bleeding. Journal of gastroenterology and hepatology 2016; 31: 761-767
- 300 Villanueva C, Colomo A, Bosch A. et al. Transfusion strategies for acute upper gastrointestinal bleeding. New England Journal of Medicine 2013; 368: 11-21
- 301 Habib A, Sanyal AJ. Acute variceal hemorrhage. Gastrointestinal endoscopy clinics of North America 2007; 17: 223-252- v
- 302 Kleber G, Sauerbruch T, Ansari H. et al. Prediction of variceal hemorrhage in cirrhosis: a prospective follow-up study. Gastroenterology 1991; 100: 1332-1337
- 303 Zoli M, Merkel C, Magalotti D. et al. Evaluation of a new endoscopic index to predict first bleeding from the upper gastrointestinal tract in patients with cirrhosis. Hepatology 1996; 24: 1047-1052
- 304 Bosch J, Abraldes JG, Berzigotti A. et al. The clinical use of HVPG measurements in chronic liver disease. Nature reviews Gastroenterology & hepatology 2009; 6: 573-582
- 305 Garcia-Pagan JC, Caca K, Bureau C. et al. Early use of TIPS in patients with cirrhosis and variceal bleeding. New England Journal of Medicine 2010; 362: 2370-2379
- 306 Garcia-Pagan JC, Di Pascoli M, Caca K. et al. Use of early-TIPS for high-risk variceal bleeding: results of a post-RCT surveillance study. Journal of hepatology 2013; 58: 45-50
- 307 Bruha R, Marecek Z, Spicak J. et al. Double-blind randomized, comparative multicenter study of the effect of terlipressin in the treatment of acute esophageal variceal and/or hypertensive gastropathy bleeding. Hepato-gastroenterology 2002; 49: 1161-1166
- 308 Zhou Y, Qiao L, Wu J. et al. Comparison of the efficacy of octreotide, vasopressin, and omeprazole in the control of acute bleeding in patients with portal hypertensive gastropathy: a controlled study. Journal of gastroenterology and hepatology 2002; 17: 973-979
- 309 Kamath PS, Lacerda M, Ahlquist DA. et al. Gastric mucosal responses to intrahepatic portosystemic shunting in patients with cirrhosis. Gastroenterology 2000; 118: 905-911
- 310 Escorsell A, Pavel O, Cardenas A. et al. Esophageal balloon tamponade versus esophageal stent in controlling acute refractory variceal bleeding: A multicenter randomized, controlled trial. Hepatology 2016; 63: 1957-1967
- 311 McCarty TR, Njei B. Self-expanding metal stents for acute refractory esophageal variceal bleeding: A systematic review and meta-analysis. Digestive endoscopy: official journal of the Japan Gastroenterological Endoscopy Society 2016; 28: 539-547
- 312 Dechêne A, El Fouly AH, Bechmann LP. et al. Acute management of refractory variceal bleeding in liver cirrhosis by self-expanding metal stents. Digestion 2012; 85: 185-191
- 313 Ibrahim M, El-Mikkawy A, Abdalla H. et al. Management of acute variceal bleeding using hemostatic powder. United European gastroenterology journal 2015; 3: 277-283
- 314 Qi X, Jia J, Bai M. et al. Transjugular Intrahepatic Portosystemic Shunt for Acute Variceal Bleeding: A Meta-analysis. Journal of clinical gastroenterology 2015; 49: 495-505
- 315 Halabi SA, Sawas T, Sadat B. et al. Early TIPS versus endoscopic therapy for secondary prophylaxis after management of acute esophageal variceal bleeding in cirrhotic patients: a meta-analysis of randomized controlled trials. Journal of gastroenterology and hepatology 2016; 31: 1519-1526
- 316 Gülberg V, Schepke M, Geigenberger G. et al. Transjugular intrahepatic portosystemic shunting is not superior to endoscopic variceal band ligation for prevention of variceal rebleeding in cirrhotic patients: a randomized, controlled trial. Scandinavian journal of gastroenterology 2002; 37: 338-343
- 317 Pomier-Layrargues G, Villeneuve JP, Deschênes M. et al. Transjugular intrahepatic portosystemic shunt (TIPS) versus endoscopic variceal ligation in the prevention of variceal rebleeding in patients with cirrhosis: a randomised trial. Gut 2001; 48: 390-396
- 318 Sauer P, Hansmann J, Richter GM. et al. Endoscopic variceal ligation plus propranolol vs. transjugular intrahepatic portosystemic stent shunt: a long-term randomized trial. Endoscopy 2002; 34: 690-697
- 319 Burroughs AK, Vangeli M. Transjugular intrahepatic portosystemic shunt versus endoscopic therapy: randomized trials for secondary prophylaxis of variceal bleeding: an updated meta-analysis. Scandinavian journal of gastroenterology 2002; 37: 249-252
- 320 Papatheodoridis GV, Goulis J, Leandro G. et al. Transjugular intrahepatic portosystemic shunt compared with endoscopic treatment for prevention of variceal rebleeding: A meta-analysis. Hepatology 1999; 30: 612-622
- 321 Zheng M, Chen Y, Bai J. et al. Transjugular intrahepatic portosystemic shunt versus endoscopic therapy in the secondary prophylaxis of variceal rebleeding in cirrhotic patients: meta-analysis update. Journal of clinical gastroenterology 2008; 42: 507-516
- 322 Sauerbruch T, Mengel M, Dollinger M. et al. Prevention of Rebleeding From Esophageal Varices in Patients With Cirrhosis Receiving Small-Diameter Stents Versus Hemodynamically Controlled Medical Therapy. Gastroenterology 2015; 149: 660-668.e661
- 323 Barrio J, Ripoll C, Bañares R. et al. Comparison of transjugular intrahepatic portosystemic shunt dysfunction in PTFE-covered stent-grafts versus bare stents. European journal of radiology 2005; 55: 120-124
- 324 Bureau C, Pagán JCG, Layrargues GP. et al. Patency of stents covered with polytetrafluoroethylene in patients treated by transjugular intrahepatic portosystemic shunts: long-term results of a randomized multicentre study. Liver international: official journal of the International Association for the Study of the Liver 2007; 27: 742-747
- 325 Boyer TD, Haskal ZJ. Diseases AAftSoL. The Role of Transjugular Intrahepatic Portosystemic Shunt (TIPS) in the Management of Portal Hypertension: update 2009. Wiley Subscription Services, Inc., A Wiley Company 2010; 306
- 326 Tesdal IK, Filser T, Weiss C. et al. Transjugular intrahepatic portosystemic shunts: adjunctive embolotherapy of gastroesophageal collateral vessels in the prevention of variceal rebleeding. Radiology 2005; 236: 360-367
- 327 Chen S, Li X, Wei B. et al. Recurrent variceal bleeding and shunt patency: prospective randomized controlled trial of transjugular intrahepatic portosystemic shunt alone or combined with coronary vein embolization. Radiology 2013; 268: 900-906
- 328 Park JK, Saab S, Kee ST. et al. Balloon-Occluded Retrograde Transvenous Obliteration (BRTO) for Treatment of Gastric Varices: Review and Meta-Analysis. Digestive diseases and sciences 2015; 60: 1543-1553
- 329 Henderson JM, Boyer TD, Kutner MH. et al. Distal Splenorenal Shunt Versus Transjugular Intrahepatic Portal Systematic Shunt for Variceal Bleeding: A Randomized Trial. Gastroenterology 2006; 130: 1643-1651
- 330 Bernard B, Cadranel JF, Valla D. et al. Prognostic significance of bacterial infection in bleeding cirrhotic patients: a prospective study. Gastroenterology 1995; 108: 1828-1834
- 331 Bleichner G, Boulanger R, Squara P. et al. Frequency of infections in cirrhotic patients presenting with acute gastrointestinal haemorrhage. The British journal of surgery 1986; 73: 724-726
- 332 Hou MC, Lin HC, Liu TT. et al. Antibiotic prophylaxis after endoscopic therapy prevents rebleeding in acute variceal hemorrhage: a randomized trial. Hepatology 2004; 39: 746-753
- 333 Hsieh WJ, Lin HC, Hwang SJ. et al. The effect of ciprofloxacin in the prevention of bacterial infection in patients with cirrhosis after upper gastrointestinal bleeding. The American journal of gastroenterology 1998; 93: 962-966
- 334 Soriano G, Guarner C, Tomas A. et al. Norfloxacin prevents bacterial infection in cirrhotics with gastrointestinal hemorrhage. Gastroenterology 1992; 103: 1267-1272
- 335 Pauwels A, Mostefa-Kara N, Debenes B. et al. Systemic antibiotic prophylaxis after gastrointestinal hemorrhage in cirrhotic patients with a high risk of infection. Hepatology 1996; 24: 802-806
- 336 Brown MR, Jones G, Nash KL. et al. Antibiotic prophylaxis in variceal hemorrhage: timing, effectiveness and Clostridium difficile rates. World journal of gastroenterology: WJG 2010; 16: 5317-5323
- 337 Ioannou G, Doust J, Rockey DC. Terlipressin for acute esophageal variceal hemorrhage. The Cochrane database of systematic reviews 2003; DOI: 10.1002/14651858.CD002147: CD002147.
- 338 Tripodi A, Mannucci PM. The coagulopathy of chronic liver disease. The New England journal of medicine 2011; 365: 147-156
- 339 Tripodi A, Salerno F, Chantarangkul V. et al. Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests. Hepatology 2005; 41: 553-558
- 340 Bosch J, Thabut D, Albillos A. et al. Recombinant factor VIIa for variceal bleeding in patients with advanced cirrhosis: A randomized, controlled trial. Hepatology 2008; 47: 1604-1614
- 341 Bosch J, Thabut D, Bendtsen F. et al. Recombinant factor VIIa for upper gastrointestinal bleeding in patients with cirrhosis: a randomized, double-blind trial. Gastroenterology 2004; 127: 1123-1130
- 342 Bendtsen F, D'Amico G, Rusch E. et al. Effect of recombinant Factor VIIa on outcome of acute variceal bleeding: an individual patient based meta-analysis of two controlled trials. Journal of hepatology 2014; 61: 252-259
- 343 Jairath V, Rehal S, Logan R. et al. Acute variceal haemorrhage in the United Kingdom: patient characteristics, management and outcomes in a nationwide audit. Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2014; 46: 419-426
- 344 Sorbi D, Gostout CJ, Peura D. et al. An assessment of the management of acute bleeding varices: a multicenter prospective member-based study. The American journal of gastroenterology 2003; 98: 2424-2434
- 345 Lo EA, Wilby KJ, Ensom MH. Use of proton pump inhibitors in the management of gastroesophageal varices: a systematic review. Ann Pharmacother 2015; 49: 207-219
- 346 Sharma P, Agrawal A, Sharma BC. et al. Prophylaxis of hepatic encephalopathy in acute variceal bleed: a randomized controlled trial of lactulose versus no lactulose. Journal of gastroenterology and hepatology 2011; 26: 996-1003
- 347 Maharshi S, Sharma BC, Srivastava S. et al. Randomised controlled trial of lactulose versus rifaximin for prophylaxis of hepatic encephalopathy in patients with acute variceal bleed. Gut 2015; 64: 1341-1342
- 348 Bari K, Garcia-Tsao G. Treatment of portal hypertension. World journal of gastroenterology: WJG 2012; 18: 1166-1175
- 349 Gatta A, Merkel C, Sacerdoti D. et al. Nadolol for prevention of variceal rebleeding in cirrhosis: a controlled clinical trial. Digestion 1987; 37: 22-28
- 350 D'Amico G, Pagliaro L, Bosch J. Pharmacological treatment of portal hypertension: an evidence-based approach. Seminars in liver disease 1999; 19: 475-505
- 351 Gournay J, Masliah C, Martin T. et al. Isosorbide mononitrate and propranolol compared with propranolol alone for the prevention of variceal rebleeding. Hepatology 2000; 31: 1239-1245
- 352 Gluud LL, Langholz E, Krag A. Meta-analysis: isosorbide-mononitrate alone or with either beta-blockers or endoscopic therapy for the management of oesophageal varices. Alimentary pharmacology & therapeutics 2010; 32: 859-871
- 353 Lo GH, Chen WC, Wang HM. et al. Randomized, controlled trial of carvedilol versus nadolol plus isosorbide mononitrate for the prevention of variceal rebleeding. Journal of gastroenterology and hepatology 2012; 27: 1681-1687
- 354 Abraldes JG, Villanueva C, Aracil C. et al. Addition of Simvastatin to Standard Therapy for the Prevention of Variceal Rebleeding Does Not Reduce Rebleeding but Increases Survival in Patients With Cirrhosis. Gastroenterology 2016; 150: 1160-1170 e1163
- 355 Lo GH, Chen WC, Chen MH. et al. Banding ligation versus nadolol and isosorbide mononitrate for the prevention of esophageal variceal rebleeding. Gastroenterology 2002; 123: 728-734
- 356 Lo GH, Chen WC, Lin CK. et al. Improved survival in patients receiving medical therapy as compared with banding ligation for the prevention of esophageal variceal rebleeding. Hepatology 2008; 48: 580-587
- 357 Li L, Yu C, Li Y. Endoscopic band ligation versus pharmacological therapy for variceal bleeding in cirrhosis: a meta-analysis. Canadian journal of gastroenterology = Journal canadien de gastroenterologie 2011; 25: 147-155
- 358 Cheung J, Zeman M, van Zanten SV. et al. Systematic review: secondary prevention with band ligation, pharmacotherapy or combination therapy after bleeding from oesophageal varices. Alimentary pharmacology & therapeutics 2009; 30: 577-588
- 359 Ding SH, Liu J, Wang JP. Efficacy of beta-adrenergic blocker plus 5-isosorbide mononitrate and endoscopic band ligation for prophylaxis of esophageal variceal rebleeding: a meta-analysis. World journal of gastroenterology: WJG 2009; 15: 2151-2155
- 360 Ravipati M, Katragadda S, Swaminathan PD. et al. Pharmacotherapy plus endoscopic intervention is more effective than pharmacotherapy or endoscopy alone in the secondary prevention of esophageal variceal bleeding: a meta-analysis of randomized, controlled trials. Gastrointestinal endoscopy 2009; 70: 658-664 e655
- 361 Stanley AJ, Dickson S, Hayes PC. et al. Multicentre randomised controlled study comparing carvedilol with variceal band ligation in the prevention of variceal rebleeding. Journal of hepatology 2014; 61: 1014-1019
- 362 Thiele M, Krag A, Rohde U. et al. Meta-analysis: banding ligation and medical interventions for the prevention of rebleeding from oesophageal varices. Alimentary Pharmacology & Therapeutics 2012; 35: 1155-1165
- 363 Puente A, Hernandez-Gea V, Graupera I. et al. Drugs plus ligation to prevent rebleeding in cirrhosis: an updated systematic review. Liver international: official journal of the International Association for the Study of the Liver 2014; 34: 823-833
- 364 Mandorfer M, Bota S, Schwabl P. et al. Nonselective beta blockers increase risk for hepatorenal syndrome and death in patients with cirrhosis and spontaneous bacterial peritonitis. Gastroenterology 2014; 146: 1680-1690 e1681
- 365 Mishra SR, Chander Sharma B, Kumar A. et al. Endoscopic cyanoacrylate injection versus beta-blocker for secondary prophylaxis of gastric variceal bleed: a randomised controlled trial. Gut 2010; 59: 729-735
- 366 Luca A, D'Amico G, La Galla R. et al. TIPS for prevention of recurrent bleeding in patients with cirrhosis: meta-analysis of randomized clinical trials. Radiology 1999; 212: 411-421
- 367 Khan S, Tudur Smith C, Williamson P. et al. Portosystemic shunts versus endoscopic therapy for variceal rebleeding in patients with cirrhosis. The Cochrane database of systematic reviews 2006; DOI: 10.1002/14651858.CD000553.pub2: CD000553.
- 368 Windecker S, Kolh P. Authors/Task Force m. et al. 2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). European heart journal 2014; 35: 2541-2619
- 369 Roffi M, Patrono C, Collet JP. et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). European heart journal 2016; 37: 267-315
- 370 Adler DG, Leighton JA, Davila RE. et al. ASGE guideline: The role of endoscopy in acute non-variceal upper-GI hemorrhage. Gastrointestinal endoscopy 2004; 60: 497-504
- 371 El Ouali S, Barkun AN, Wyse J. et al. Is routine second-look endoscopy effective after endoscopic hemostasis in acute peptic ulcer bleeding? A meta-analysis. Gastrointestinal endoscopy 2012; 76: 283-292
- 372 Chiu PW, Joeng HK, Choi CL. et al. High-dose omeprazole infusion compared with scheduled second-look endoscopy for prevention of peptic ulcer rebleeding: a randomized controlled trial. Endoscopy 2016; 48: 717-722
- 373 Imperiale TF, Kong N. Second-look endoscopy for bleeding peptic ulcer disease: a decision-effectiveness and cost-effectiveness analysis. Journal of clinical gastroenterology 2012; 46: e71-e75
- 374 Qureshi W, Adler DG, Davila R. et al. ASGE Guideline: the role of endoscopy in the management of variceal hemorrhage, updated July 2005. Gastrointestinal endoscopy 2005; 62: 651-655
- 375 Riphaus A, Wehrmann T, Weber B. et al. S3-guidelines--sedation in gastrointestinal endoscopy. Zeitschrift fur Gastroenterologie 2008; 46: 1298-1330
- 376 Waring JP, Baron TH, Hirota WK. et al. Guidelines for conscious sedation and monitoring during gastrointestinal endoscopy. Gastrointestinal endoscopy 2003; 58: 317-322
- 377 Taeger K. Leitlinie zur Sedierung und Analgesie (Analgosedierung) von Patienten durch Nicht-Anästhesisten. Anästh Intensivmed 2002; 43: 639-641
- 378 Amornyotin S, Chal W, Kongphlay S. Recovery pattern and home-readiness after ambulatory gastrointestinal endoscopy. J Med Assoc Thai 2007; 90: 2352-2358
- 379 Dumonceau JM, Riphaus A, Schreiber F. et al. Non-anesthesiologist administration of propofol for gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy, European Society of Gastroenterology and Endoscopy Nurses and Associates Guideline--Updated June 2015. Endoscopy 2015; 47: 1175-1189