Semin Respir Crit Care Med 2001; 22(6): 665-674
DOI: 10.1055/s-2001-18803
Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Hepatic Hydrothorax

José Ribas Milanez de Campos1 , Laert Oliveira Andrade Filho1 , Eduardo de Campos Werebe1 , Fernando Luiz Pandulo, Luiz Tarcísio Brito Filomeno1 , Fabio Biscegli Jatene1
  • 1Division of Thoracic Surgery, Hospital das Clínicas of the University of São Paulo Medical School, São Paulo, Brazil
  • 2Division of Hepathology, Hospital Israelita Albert Einstein, São Paulo, Brazil
Further Information

Publication History

Publication Date:
05 December 2001 (online)

ABSTRACT

Hepatic hydrothorax (HH) is an uncommon manifestation of cirrhosis with ascites. Pleural effusions form when ascitic fluid moves through diaphragmatic defects that have been opened by increased peritoneal pressure. The diagnosis is established clinically by finding a serous transudate and is confirmed by radionuclide imaging demonstrating communication between the peritoneal and pleural spaces. In end-stage liver disease, the management of hepatic hydrothorax is problematic and often does not respond to medical therapy. Therapeutic options for a refractory hepatic hydrothorax include therapeutic thoracentesis, talc slurry through a chest tube, peritoneovenous and pleurovenous shunting, thoracoscopic talc poudrage, transjugular intrahepatic portosystemic shunt (TIPS), thoracosopic diaphragmatic defect repair followed by talc poudrage, and lastly, liver transplant. TIPS can be used as a bridge for transplantation but is often complicated by encephalopathy. Video assisted thoracic surgery (VATS) with patching the defect and talc poudrage may provide symptomatic relief; however, the morbidity and mortality in these extremely ill patients is high. The only definitive treatment for refractory hepatic hydrothorax associated with end-stage cirrhosis is liver transplantation.

REFERENCES

  • 1 Zenda T, Miyamoto S, Murata S, Mabuchi H. Detection of diaphragmatic defect as the cause of severe hepatic hydrothorax with magnetic resonance imaging.  Am J Gastroenterol . 1998;  93 2288-2289
  • 2 Mouroux J, Perrin C, Venissac N. Management of pleural effusion of cirrhotic origin.  Chest . 1996;  109 1093-1096
  • 3 Alberts W M, Salem A J, Solomon D A. Hepatic hydrothorax: cause and management.  Arch Intern Med . 1991;  151 2383-2388
  • 4 Gordon F D, Anastopoulos H T, Crenshaw W. The successful treatment of symptomatic, refractory hepatic hydrothorax with transjugular intrahepatic portosystemic shunt.  Hepatology . 1997;  25 1366-1369
  • 5 Ellis G, Laurin J. Hepatic hydrothorax: diagnosis and management: case report and review of the literature.  Maryland Medical Journal . 1999;  48 295-298
  • 6 Daly J J, Potts J M, Gordon L. Scintigraphic diagnosis of peritoneal-pleural communication in the absence of ascites.  Clin Nucl Med . 1994;  19 892-894
  • 7 Kakizaki S, Katakai K, Yoshinaga T. Hepatic hydrothorax in the absence of ascites.  Liver . 1998;  18 216-220
  • 8 Haitjema T, Maat C EM. Pleural effusion without ascites in a patient with cirrhosis.  Nether J Med . 1994;  44 207-209
  • 9 Kirsch C M, Chui D W, Yenokida G G. Case report: hepatic hydrothorax without ascites.  Am J Med Sci . 1991;  302 103-106
  • 10 Leuallen E C, Carr D T. Pleural effusion: a statistical study of 436 patients.  N Eng J Med . 1955;  252 79-83
  • 11 Strauss R M, Martin L G, Kaufman S L. Transjugular intrahepatic portal systemic shunt for the management of symptomatic cirrhotic hydrothorax.  Am J Gastroenterol . 1994;  94 1520-1522
  • 12 Nakamura A, Kojima Y, Ohmi H. Peritoneal-pleural communications in hepatic hydrothorax demonstrated by thoracoscopy.  Chest . 1996;  109 579-581
  • 13 Giacobbe A, Facciorusso D, Barbano F. Hepatic hydrothorax: diagnosis and management.  Clinical Nuclear Medicine . 1996;  21 56-60
  • 14 Kirschner P A. Porous diaphragm syndromes.  Chest Surg Clin N Am . 1998;  8 449-472
  • 15 Temes T, Davis M S, Follis F M. Videothoracoscopic treatment of hepatic hydrothorax.  Ann Thorac Surg . 1997;  64 1468-1469
  • 16 Yaguchi T, Harada A, Sakakibara T. A successful surgical repair of the hepatic hydrothorax using pneumoperitoneum: report of a case.  Surg Today . 1999;  29 795-798
  • 17 Williams M H. Pleural effusion produced by abdomino pleural communication in a patient with Laënnec's cirrhosis of the liver and ascites.  Ann Intern Med . 1950;  33 216-21
  • 18 Park S Z, Shrager J B, Allen M S. Treatment of refractory nonmalignant hydrothorax with a pleurovenous shunt.  Ann Thorac Surg . 1997;  63 1777-1779
  • 19 Degawa M, Hamasaki K, Yano K. Refractory hepatic hydrothorax treated with transjugular intrahepatic portosystemic shunt.  J Gastroenterol . 1999;  34(1) 128-131
  • 20 Di Bisceglie D M, Paladini P, Voltolini L. Videothoracoscopic obliteration of pleuroperitoneal fistula in continuous peritoneal dialysis.  Ann Thorac Surg . 1996;  62 1509-1510
  • 21 Mentes B B, Kayhan B, Gorgul A, Unal S. Hepatic hydrothorax in the absence of ascites: report of two reviews of the mechanism.  Dig Dis Sci . 1997;  42 781-788
  • 22 Emerson P A, Davies J H. Hydrothorax complicating ascites.  Lancet . 1955;  1 487-488
  • 23 Strauss R M, Boyer T D. Hepatic hydrothorax.  Semn Liv Dis . 1997;  17 227-232
  • 24 Lazaridis K N, Frank J W, Krowka M J, Kamath P S. Hepatic hydrothorax: pathogenesis, diagnosis, and management.  Am J Med . 1999;  107 262-267
  • 25 Sadler T W. Langman's Medical Embryology.  7th ed. Baltimore, Md: Williams and Wilkins 1995: 176-182
  • 26 Sawabe J, Ishida H, Niizawa M. Sonographic demonstration of diaphragmatic fistula in a patient with hepatic hydrothorax.  Akita J Med . 1992;  19 615-619
  • 27 Raju E PV, Rad P N, Verilateswarlu J. Ultrasound documentation of diaphragmatic tent in hepatic hydrothorax.  Indian J Gastroenterol . 1989;  8 111-112
  • 28 Arroyo V, Gines P, Gerbes A L. Definition and diagnostic criteria of ascites and hepatorenal syndrome in cirrhosis.  Hepatology . 1996;  23 164-176
  • 29 Morrow C S, Kantor M, Armen R N. Hepatic hydrothorax.  Ann Intern Med . 1958;  49 193-203
  • 30 Gordon F D, Anastopoulos H T, Crenshaw W. The successful treatment of symptomatic, refractory hepatic hydrothorax with transjugular intrahepatic portosystemic shunt.  Hepatology . 1997;  25 1366-1369
  • 31 Dumortier J, Lepetre J, Scalone O. Successful treatment of hepatic hydrothorax with octreotide.  Eur J Gastroenterol Hepatol . 2000;  12 817-820
  • 32 Kaffy F, Borderie C, Chagneau C. Octreotide in the treatment of the hepatorenal syndrome in cirrhotic patients.  J Hepatol . 1999;  30 174
  • 33 Angeli P, Volpin R, Gerunda G. Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide.  Hepatology . 1999;  29 1690-1697
  • 34 Runyon B A, Greenblatt M, Ring M HC. Hepatic hydrothorax is a relative contraindication to chest tube insertion.  Am J Gastroenterol . 1986;  81 566-567
  • 35 Falchuk K R, Jacoby I, Colucci W S. Tetracycline-induced pleural symphysis for recurrent hydrothorax complicating cirrhosis: a new approach to treatment.  Gastroenterology . 1977;  72 319-323
  • 36 Yim A PC, Chan A TC, Lee T W. Thoracoscopic talc insufflation versus talc slurry for symptomatic malignant pleural effusion.  Ann Thorac Surg . 1996;  62 1655-1658
  • 37 Colombo A, Boncinelli L, Pinzi M. Un nuovo approccio terapeutico nell'idrotorace epatico.  Minerva Med . 1992;  83 219-222
  • 38 Lin C C, Wu J C. Resolution of refractory hepatic hydrothorax after chemical pleurodesis with minocycline.  Zhonghua Yi Xve Za Zhi (Taipei) . 2000;  63 704-709
  • 39 Vargas F S, Milanez J RC, Filomeno L TB. Intrapleural talc for the prevention of recurrent in benign or undiagnosed pleural effusions.  Chest . 1994;  106 1771-1775
  • 40 Milanez J RC, Vargas F S, Filomeno L TB. Intrapleural talc for the prevention of recurrent pneumothorax.  Chest . 1994;  106 1162-1165
  • 41 Ohri S K, Oswal S K, Townsend E R. Early and late outcome after diagnostic thoracoscopy and talc pleurodesis.  Ann Thorac Surg . 1992;  53 1038-1041
  • 42 Xiol X, Castellvi J M, Guardiola J. Spontaneous bacterial empyema in cirrhotic patients: a prospective study.  Hepatology . 1996;  23 719-723
  • 43 Abba A A, Laajam M A, Zargar S A. Spontaneous neutrocytic hepatic hydrothorax without ascites.  Respir Med . 1996;  90 631-634
  • 44 Hobbs C L, Mullen J L, Rossato E F. Peritoneovenous shunt for hydrothorax associated with ascites.  Arch Surg . 1982;  117 1233-1234
  • 45 LeVeen H H, Piccone V A, Hutto R B. Management of ascites with hydrothorax.  Am J Surg . 1984;  148 210-213
  • 46 Ikard R W, SawyersJL. Persistent hepatic hydrothorax after peritoneovenous shunt.  Asch Surg . 1980;  115 1125-1129
  • 47 Ghandour E, Carter J, Feola M. Management of hepatic hydrothorax with a peritoneovenous shunt.  Southern Med J . 1990;  83 718-719
  • 48 Rubinstein D, McInnes I E, Duddley F G. Hepatic hydrothorax in the absence of clinical ascites: diagnosis and management.  Gastroenterology . 1985;  88 188-191
  • 49 Campos J RM, Andrade Filho O L, Werebe E C. Thoracoscopy and talc poudrage in the management of hepatic hydrothorax.  Chest . 2000;  118 13-17
  • 50 Rossle M, Siegerstetter V, Huber M, Ochs A. The first decade of the transjugular intrahepatic portosystemic shunt (TIPS): state of the art.  Liver . 1998;  18(2) 73-89
  • 51 Jeffries M A, Kazanjian S, Wilson M, Punch J, Fontana R J. Transjugular intrahepatic portosystemic shunts and liver transplantation in patients with refractory hepatic hydrothorax.  Liver Transpl Surg . 1998;  4(5) 416-423
  • 52 Freedman A M, Sanyal A J, Tisnado J. Complications of transjugular intrahepatic portosystemic shunt: a comprehensive review.  Radiographics . 1993;  13 1185-1210
  • 53 Lind C D, Malisch T W, Chong W K. Incidence of shunt occlusion or stenosis with transjugular intrahepatic portosystemic shunts.  Gastroenterology . 1993;  104 A941
  • 54 Ong J P, Sands M, Younossi Z M. Transjugular intrahepatic portosystemic shunts TIPS: a decade later.  J Clin Gastroenterol . 2000;  30 14-28
  • 55 Van der Linden P, Le Moine O, Ghysels M. Pulmonary hypertension after transjugular intrahepatic portosystemic shunt: effects on right ventricular function.  Hepatology . 1996;  23 982-987
  • 56 Henderson J M, Nagle A, Curtas S, Geisinger M, Barnes D. Surgical shunts and TIPS for variceal decompression in the 1990s.  Surgery . 2000;  128 540-547
  • 57 Ochs A, Rossele M, Haag K. The transjugular intrahepatic portosystemic stent shunt procedure for refractory ascites.  N Engl J Med . 1995;  332 1192-1197
  • 58 Lerut P S, Goffette P, Molle G. Transjugular intrahepatic portosystemic shunt after adult liver transplantation.  Transplantation . 1999;  68 379-384
  • 59 Kirsch C M. Cirrhotic hydrothorax and the law of unintended consequences [editorial].  Chest . 2000;  118 2-4
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