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Planta Med 2002; 68(1): 72-73
DOI: 10.1055/s-2002-20048
Letter

© Georg Thieme Verlag Stuttgart · New York

Iridoids with Anti-Inflammatory Activity from Vitex peduncularis

A. Suksamrarn1 , S. Kumpun1 , K. Kirtikara2 , B. Yingyongnarongkul1 , S. Suksamrarn3
  • 11 Department of Chemistry, Ramkhamhaeng University, Bangkok, Thailand
  • 22 National Centre for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Bangkok, Thailand
  • 33 Department of Chemistry, Srinakharinwirot University, Bangkok, Thailand
Further Information

Publication History

February 9, 2001

May 13, 2001

Publication Date:
31 January 2002 (online)

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Abstract

A new iridoid, pedunculariside, together with the known iridoid agnuside were isolated from the butanol extract of Vitex peduncularis stem bark. Both pedunculariside and agnuside showed preferential inhibition of COX-2, with IC50 values of 0.15 ± 0.21 mg/ml and 0.026 ± 0.015 mg/ml respectively, while having only small inhibitory effects on COX-1. Both compounds did not exhibit cytotoxicity against vero cells.

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Prof. Dr. Assoc. A. Suksamrarn

Department of Chemistry

Faculty of Science

Ramkhamhaeng University

Bangkok 10240

Thailand

Email: apichart@ram1.ru.ac.th

Fax: +66 2-3108381

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