Inhibitory Effects of Natural Sesquiterpenoids Isolated from the Rhizomes of Curcuma zedoaria on Prostaglandin E₂ and Nitric Oxide Production

 

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Abstract

β-Turmerone and ar-turmerone, sesquiterpenoids isolated from the rhizome of Curcuma zedoaria, inhibited lipopolysaccharide (LPS)-induced prostaglandin E₂ production in cultured mouse macrophage cell RAW 264.7 in a dose-dependent manner (IC₅₀ = 7.3 μM for β-turmerone; IC₅₀ = 24.0 μM for ar-turmerone). In addition, these compounds exhibited inhibitory effects on LPS-induced nitric oxide production in the cell system.

• 1 Matsuda H, Ninomiya T, Yoshikawa M. Inhibitory effect and action mechanism of sesquiterpenes from Zedoariae rhizoma on D-galactosamine/lipopolysaccharide-induced liver injury.  Bioorg Med Chem Lett. 1998;  8 339-44
  CrossrefPubMedGoogle Scholar
• 2 Yoshioka T, Fujii E, Endo M, Wada K, Tokunaga Y, Shiba N, Hohsho H, Shibuya H, Muraki T. Anti-inflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene.  Inflammation Res. 1998;  47 476-81
  PubMedGoogle Scholar
• 3 Hong C H, Kim Y, Lee S K. Sesquiterpenoids from the rhizome of Curcuma zedoaria .  Arch Pharm Res. 2001;  24 424-6
  PubMedGoogle Scholar
• 4 Pradelles P, Grassi J, Maclouf J. Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: An alternative to radioimmunoassay.  Anal Chem. 1985;  57 1170-3
  CrossrefPubMedGoogle Scholar
• 5 Kim H K, Cheon B S, Kim Y H, Kim S Y, Kim H P. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW264.7 and their structure-activity relationships.  Biochem Pharmacol. 1999;  58 759-65
  CrossrefPubMedGoogle Scholar

Dr. Sang Kook Lee

College of Pharmacy

Ewha Womans University

11-1 Daehyun-dong

Seodaemun-ku

Seoul 120-750

Korea

Phone: +82-2-3277-3023

Fax: +82-2-3277-2851

Email: sklee@mm.ewha.ac.kr