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Planta Med 2003; 69(4): 350-355
DOI: 10.1055/s-2003-38883
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

New Antimicrobial Alkaloids from the Roots of Polyalthia longifolia var. pendula

Shaheen Faizi1 , Rashid Ali Khan1 , Soobia Azher2 , Shakeel Ahmed Khan2 , Saima Tauseef2 , Aqeel Ahmad2
  • 1H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan
  • 2Department of Microbiology, University of Karachi, Karachi, Pakistan
Further Information

Publication History

Received: July 18, 2002

Accepted: December 22, 2002

Publication Date:
23 April 2003 (online)

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Abstract

Bioassay-guided isolation studies on the root extract of Polyalthia longifolia var. pendula possessing significant antibacterial activity led to the isolation of three new alkaloids pendulamine A (1), pendulamine B (2) and penduline (3) along with stigmasterol 3-O-β-D-glucoside, allantoin, the known diterpenoid kolavenic acid, and the azafluorene alkaloid isoursuline. The structures of these compounds have been elucidated with the help of spectroscopic studies including 2D NMR experiments. Compounds 1 and 2, which are the only protoberberine alkaloids having a monosubstituted A ring with a hydroxy group at C-3, were found to be the active antibacterial principles of the roots. Their MIC values ranged between 0.02 - 20 μg against the tested bacteria.

Key words

Polyalthia longifolia var. pendula - Annonaceae - roots - alkaloids - 8-oxoprotoberberine - azafluorenones - antibacterial activity

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Prof. Dr. Shaheen Faizi

H.E.J. Research Institute of Chemistry

International Center for Chemical Sciences

University of Karachi

Karachi-75270

Pakistan

Email: shaheen@khi.comsats.net.pk

Fax: +92+21-9243190-91

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