Int J Sports Med 2003; 24(5): 337-343
DOI: 10.1055/s-2003-40702
Physiology & Biochemistry
© Georg Thieme Verlag Stuttgart · New York

Anabolic Androgenic Steroids Produce Dose-Dependent Increase in Left Ventricular Mass in Power Athletes, and this Effect is Potentiated by Concomitant Use of Growth Hormone

T. A. M. Karila1, 2, 3 , J. E.  Karjalainen4 , M. J.  Mäntysaari4 , M. T.  Viitasalo5 , T. A.  Seppälä1, 2
  • 1Laboratory of Substance Abuse, National Public Health Institute, Helsinki, Finland
  • 2Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Helsinki, Finland
  • 3Department of Orthopaedics and Traumatology, Helsinki University Central Hospital, Finland
  • 4Central Military Hospital and Research Institute of Military Medicine, Helsinki, Finland
  • 5Department of Internal Medicine, Helsinki University Central Hospital, Finland
Further Information

Publication History

Accepted after revision: January 15, 2003

Publication Date:
17 July 2003 (online)

Abstract

Power athletes abuse anabolic androgenic steroids (AASs) and growth hormone (GH) to gain their muscular mass and strength. We wanted to determine how massive, self-administered doses of AASs with or without GH affect the left ventricular (LV) dimensions in power athletes. These substances are assumed to increase LVmass mainly by thickening the ventricular walls. Anecdotal evidence suggests a higher risk of cardiovascular events in AAS abusers. We were interested to see if LV dimensions and function in AAS abusers would indicate this increased risk. Twenty healthy male power athletes using massive doses of AAS without (n = 16) or with (n = 4) GH volunteered for the study. The controls were 15 sedentary male non-users of hormones. LV mass, geometry and filling were studied using standard echocardiographic methods. We found a significant association between LV mass and AAS dose (r = 0.54, p < 0.015). In contrast to the controls, LV mass (274 g in the athletes, 167 g in the controls) among the AAS abusers did not correlate with body weight or height. Concomitant use of AAS and GH further increased LV mass and associated with concentric remodelling of LV. Multiple regression analysis indicated that the mean AAS dose accounted for 29 %, age for 14 % and systolic blood pressure for 17 % of the variance in LV mass. We concluded that AAS abuse associates dose-dependently with myocardial hypertrophy and that concomitant use of GH associates with concentric remodelling of the LV. Our findings suggest that AASs and GH have a direct effect on the myocardium.

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T. Karila

Laboratory of Substance Abuse · National Public Health Institute

Mannerheimintie 166 F · 00300 Helsinki · Finland ·

Phone: +358 9 4744 8425

Fax: +358 9 4744 8553

Email: tuomo.karila@ktl.fi

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