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Horm Metab Res 2004; 36(10): 708-715
DOI: 10.1055/s-2004-826020
Original Clinical
© Georg Thieme Verlag KG Stuttgart · New York

The Metabolic Syndrome and Incident Diabetes: Assessment of Four Suggested Definitions of the Metabolic Syndrome in a Chinese Population with High Post-prandial Glucose

J.  J.  Wang1 , G.  Hu1, 2 , M.  E.  Miettinen1 , J.  Tuomilehto1, 2
  • 1Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
  • 2Department of Public Health, University of Helsinki, Finland
Further Information

Publication History

Received 5 January 2004

Accepted after revision 24 March 2004

Publication Date:
03 November 2004 (online)

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Abstract

Aims: To assess the sensitivity and specificity of the four definitions of the metabolic syndrome for incident diabetes in both men and women. Methods: The screening survey for type 2 diabetes was conducted in 1994. A follow-up study on 627 high-risk non-diabetic individuals at baseline was carried out in 1999 in Beijing area. 70 men and 76 women developed diabetes during the five-year follow-up. Sensitivity and specificity of four definitions of the metabolic syndrome based on the NCEP, WHO, EGIR and AACE recommendations were compared by McNemar's test. Results: The metabolic syndrome based on all four definitions identified men at a 3.7 - 4.5-fold and women at a 1.6 - 2.8-fold risk of developing diabetes during 5-year follow-up. The AACE definition had the highest sensitivity for predicting diabetes (men: 0.61; women: 0.58) and lowest specificity (men: 0.71; women: 0.70). The WHO definition identified 53 % of male and 42 % female incident diabetes. The NCEP definition of adiposity as waist girth > 102 cm was the least sensitive, detecting only 27 % of incident diabetes in men; however, it was the most specific (0.91). The EGIR definition identified the lowest number of female cases (28 %) and fewer male cases (28 %) of incident diabetes, but was specific (women: 0.87; men: 0.91). Conclusions: Further studies on definition of the metabolic syndrome should focus on the potential ethnic differences in insulin resistance and anthropometric indicators for obesity.

Key words

Metabolic syndrome - Incident diabetes - Obesity - Hypertension - Hyperlipidaemia - Hyperinsulinism - Microalbuminuria

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Dr. J. Wang

Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion · National Public Health Institute, KTL/GE-Lab

Kytosuontie 11 · FIN-00300 Helsinki · Finland ·

Phone: +358-9-19127-424

Fax: +358-9-19127-425

Email: jianjun.wang@ktl.fi

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