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Planta Med 2004; 70(9): 856-860
DOI: 10.1055/s-2004-827235
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

In vitro Antiviral Diterpenes from the Brazilian Brown Alga Dictyota pfaffii

Jussara Pinheiro Barbosa1 , Renato Crespo Pereira2 , Juliana Lourenço Abrantes3 , Cláudio César Cirne dos Santos4 , Moacyr Alcoforado Rebello4 , Izabel Christina de Palmer Paixão Frugulhetti3 , Valéria Laneuville Teixeira2
  • 1Programa de Pós-graduação em Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Niterói, RJ, Brazil
  • 2Departamento de Biologia Marinha, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brazil
  • 3Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Niterói, RJ, Brazil
  • 4Instituto de Microbiologia Prof. Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Further Information

Publication History

Received: December 12, 2003

Accepted: May 20, 2004

Publication Date:
23 September 2004 (online)

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Abstract

Specimens of Dictyota pfaffii from Atol das Rocas, Northeast Brazil, afforded the rare dolabellane diterpene 10,18-diacetoxy-8-hydroxy-2, 6-dolabelladiene (1) and the new 10-acetoxy-8,18-dihydroxy-2,6-dolabelladiene (2). Reduction of 1 yielded 8,10,18-trihydroxy-2,6-dolabelladiene (3), also present in the crude extract of D. pfaffii. All three structures were assigned by 1D and 2D NMR spectral data. These substances showed strong anti-HSV-1 activity in vitro but only 3 inhibited the reverse transcriptase enzyme of HIV-1.

Key words

Dictyota pfaffii - Dictyotales - dolabellanes - marine diterpenoids - antiviral activity - HSV-1 - HIV-1

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Valéria Laneuville Teixeira

Departamento de Biologia Marinha

Instituto de Biologia

P.O. Box 100.644

Universidade Federal Fluminense

Niterói, 24001-970

RJ

Brazil

Phone: +55-21-26292311

Fax: +55-21-26292292

Email: gbmvalt@vm.uff.br

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