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Endoscopy 2005; 37(5): 466-469
DOI: 10.1055/s-2005-861093
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Ileocolonic Lymphomas: A Series of 16 Cases

T.  Saito1 , H.  Toyoda2 , M.  Yamaguchi1 , T.  Nakamura3 , S.  Nakamura4 , K.  Mukai1 , H.  Fuke5 , Y.  Wakita6 , M.  Iwata7 , Y.  Adachi2 , H.  Shiku1
  • 1Second Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan
  • 2Department of Endoscopic Medicine, Mie University School of Medicine, Tsu, Mie, Japan
  • 3Department of Gastroenterology Aichi Cancer Center Hospital, Nagoya, Aichi, Japan
  • 4Department of Pathology and Clinical Laboratories, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan
  • 5Department of Gastroenterology, Yamada Red Cross Hospital, Misono, Mie, Japan
  • 6Department of Internal Medicine, Saiseikai Matsusaka General Hospital, Matsusaka, Mie, Japan
  • 7First Department of Surgery, Mie University School of Medicine, Tsu, Mie, Japan
Further Information

Publication History

Submitted 22 October 2003

Accepted after Revision 3 November 2004

Publication Date:
20 April 2005 (online)

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Background: Colonoscopic and clinical differences between primary ileocolonic mucosa-associated lymphoid tissue (MALT) lymphoma and mantle cell lymphoma (MCL) have not been defined.
Methods: We reviewed colonoscopic and clinical features in eight patients with primary MALT lymphoma and eight patients with MCL in the terminal ileum and/or colorectum. All cases were examined for CD5 and/or cyclin D1 expression.
Results: Endoscopic features of MALT lymphoma were characterized as protrusions that were covered with normal-appearing mucosa with or without ulceration. The gross appearances of MALT lymphomas were categorized as solitary (4 patients), multiple (3 patients), and multiple lymphomatous polyposis (MLP) (1 patient). The gross features of MCL at endoscopy were categorized as multiple protrusions (2 patients), and MLP (6 patients). The clinical stages of patients with MCL were more advanced than in patients with MALT lymphoma.
Conclusions: Solitary or multiple protrusions at an early clinical stage is the most common presentation pattern of patients with MALT lymphoma, but an MLP appearance at an early stage is also possible. On the other hand, MLP appearance with an advanced clinical stage is the main presentation pattern in patients with MCL, although multiple protrusions with an early clinical stage is also possible. Histological and immunohistochemical investigation including that of cyclin D1 and CD5 expression is essential to make the final diagnosis.

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H. Toyoda, M. D.

Department of Endoscopic Medicine · Mie University School of Medicine

2-174 Edobashi · Tsu Mie Prefecture 514-8507 · Japan

Fax: +81-59-2315200

Email: toyoda-t@ztv.ne.jp

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