Planta Med 2006; 72(3): 276-278
DOI: 10.1055/s-2005-916174
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Antiproliferative and Apoptotic Effects of Butyrolactone Lignans from Arctium lappa on Leukemic Cells

T. Matsumoto1 , K. Hosono-Nishiyama1 , H. Yamada1
  • 1Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University and Oriental Medicine Research Center, The Kitasato Institute. Tokyo, Japan
Further Information

Publication History

Received: June 29, 2005

Accepted: August 3, 2005

Publication Date:
05 December 2005 (online)

Abstract

In the course of screening for pharmacologically active substances from extracts of crude drugs used traditionally in Sino-Japanese herbal medicines, it was found that the 70 % ethanol extract from the fruits of Arctium lappa L. (Compositae) showed potent antiproliferative activity against B cell hybridoma cell, MH60. By bioassay-guided purification, a new lignan, (+)-7,8-didehydroarctigenin, together with the known lignans (-)-arctigenin and (-)-matairesinol were isolated as the active ingredients from an aqueous ethanolic extract of the fruits of A. lappa. Of these active compounds, (-)-arctigenin showed the most potent antiproliferative activity against MH60 cells (IC50 : 1.0 μM), and the activity was suggested to be due to apoptosis.

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Prof. Dr. H. Yamada

Kitasato Institute for Life Sciences

Kitasato University

5-9-1 Shirokane

Minato-ku

Tokyo 108-8641

Japan

Fax: +81-3-5791-6121

Email: yamada@lisci.kitasato-u.ac.jp

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