Exp Clin Endocrinol Diabetes 2006; 114(8): 412-416
DOI: 10.1055/s-2006-924153
Article

© J. A. Barth Verlag in Georg Thieme Verlag KG · Stuttgart · New York

Prevalence of Glutamic Acid Decarboxylase Antibody Positivity and its Association with Insulin Secretion and Sensitivity in Autoimmune Thyroid Disease: A Pilot Study[1]

D. Y. Aksoy 1 , B. P. Ş. Yürekli 1 , B. O. Yıldız 1 , 2 , O. Gedik 1 , 2
  • 1Hacettepe University Faculty of Medicine, Department of Internal Medicine, Ankara, Turkey
  • 2Hacettepe University Faculty of Medicine, Endocrinology and Metabolism Unit, Ankara, Turkey
Further Information

Publication History

Received: December 19, 2005 First decision: March 15, 2006

Accepted: April 3, 2006

Publication Date:
13 October 2006 (online)

Abstract

Objective: Type 1 diabetes and autoimmune thyroid disease are commonly associated. Few studies have addressed islet-cell autoimmunity and its relation with glucose homeostasis in Hashimoto's thyroiditis. The aims of this study were: (1) to determine the prevalence of islet-cell autoimmunity, and (2) to compare insulin sensitivity and secretion patterns between normal glucose tolerant glutamic acid decarboxylase antibodies (GA-D-Ab) positive and negative patients with Hashimoto's thyroidi-tis. Methods: Two hundred fifty-three consecutive patients with Hashimoto's thyroiditis were recruited. After excluding 38 patients with diabetes mellitus, 215 were screened for presence of GAD-Ab. Nine GAD-Ab positive and 8 age, sex and body mass index (BMI) matched GAD-Ab negative patients from the same cohort were included. Frequently sampled intravenous glucose tolerance tests (FSIGTT) were applied. Using glucose and insulin data from FSIGTT, fasting glucose to insulin ratio, HOMA-IR and HOMA-β-cell function, using the minimal model analysis (MIN-MOD) program, the first phase insulin secretion in response to glucose, the insulin sensitivity index and glucose sensitivity index were calculated. Results: Eleven patients were positive for GAD-Ab (5.1%). There was no difference in any insulin sensitivity or secretion parameters between the GAD-Ab positive and negative patients. Conclusions: Our results suggest that the prevalence GAD-Ab in Hashimoto's thyroiditis is around 5%. GAD-Ab antibody positivity per se does not appear to be associated with any disturbances in insulin sensitivity or insulin secretion in this specific population. The presence of islet-cell autoimmunity does not seem to influence insulin secretion or action in normal glucose tolerant subjects with Hashimoto's thyroiditis in this pilot study. Whether the presence of GAD-Ab per se or along with other antibodies impairs insulin dynamics or predicts the development of diabetes in autoimmune thyroiditis remains to be determined in future studies.

1 This study was supported by a grant (No: 0101101017) of Hacettepe University Faculty of Medicine Research Funds

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1 This study was supported by a grant (No: 0101101017) of Hacettepe University Faculty of Medicine Research Funds

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