Semin Liver Dis 2006; 26(4): 363-372
DOI: 10.1055/s-2006-951601
Copyright © 2006 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Hepatic Imaging in the 21st Century

Emil I. Cohen1 , Eric J. Wilck1 , Robert S. Shapiro1
  • 1Department of Radiology, Mount Sinai School of Medicine, New York, New York
Further Information

Publication History

Publication Date:
18 October 2006 (online)

ABSTRACT

Imaging of the liver has progressed rapidly during the past decade with continued advancement of current ultrasound, computed tomography, and magnetic resonance imaging (MRI). Each modality not only has seen refinement enabling better anatomic characterization of disease but also has received strength from the addition of new techniques to its resources. New contrast agents have become available for all modalities and some agents, particularly for MRI, have opened the way for better functional assessment. MRI continues to see an elaboration of sequences (including spectroscopy and diffusion) that also open imaging to the microscopic structure of disease and normal function. The further development of workstations have improved both analysis and depiction of disease. In the 21st century imaging will continue to shift from a simple source of anatomic information to a more functional problem-solving tool.

REFERENCES

  • 1 Gambarin-Gelwan M, Wolf D C, Shapiro R, Schwartz M E, Min A D. Sensitivity of commonly available screening tests in detecting hepatocellular carcinoma in cirrhotic patients undergoing liver transplantation.  Am J Gastroenterol. 2000;  95 1535-1538
  • 2 Chalasani N, Horlander Sr J C, Said A et al.. Screening for hepatocellular carcinoma in patients with advanced cirrhosis.  Am J Gastroenterol. 1999;  94 2988-2993
  • 3 Federle M P. Use of radiologic techniques to screen for hepatocellular carcinoma.  J Clin Gastroenterol. 2002;  35 S92-S100
  • 4 Colli A, Fraquelli M, Casazza G et al.. Accuracy of ultrasonography, spiral CT, magnetic resonance, and alpha-fetoprotein in diagnosing hepatocellular carcinoma: a systematic review.  Am J Gastroenterol. 2006;  101 513-523
  • 5 Dodd III G D, Zajko A B, Orons P D, Martin M S, Eichner L S, Santaguida L A. Detection of transjugular intrahepatic portosystemic shunt dysfunction: value of duplex Doppler sonography.  AJR Am J Roentgenol. 1995;  164 1119-1124
  • 6 Haskal Z J, Carroll J W, Jacobs J E et al.. Sonography of transjugular intrahepatic portosystemic shunts: detection of elevated portosystemic gradients and loss of shunt function.  J Vasc Interv Radiol. 1997;  8 549-556
  • 7 Zizka J, Elias P, Krajina A et al.. Value of Doppler sonography in revealing transjugular intrahepatic portosystemic shunt malfunction: a 5-year experience in 216 patients.  AJR Am J Roentgenol. 2000;  175 141-148
  • 8 Kok T, Slooff M J, Thijn C J et al.. Routine Doppler ultrasound for the detection of clinically unsuspected vascular complications in the early postoperative phase after orthotopic liver transplantation.  Transpl Int. 1998;  11 272-276
  • 9 Uzochukwu L N, Bluth E I, Smetherman D H et al.. Early postoperative hepatic sonography as a predictor of vascular and biliary complications in adult orthotopic liver transplant patients.  AJR Am J Roentgenol. 2005;  185 1558-1570
  • 10 Fuss M, Salter B J, Cavanaugh S X et al.. Daily ultrasound-based image-guided targeting for radiotherapy of upper abdominal malignancies.  Int J Radiat Oncol Biol Phys. 2004;  59 1245-1256
  • 11 Milsom J W, Jerby B L, Kessler H, Hale J C, Herts B R, O'Malley C M. Prospective, blinded comparison of laparoscopic ultrasonography vs. contrast-enhanced computerized tomography for liver assessment in patients undergoing colorectal carcinoma surgery.  Dis Colon Rectum. 2000;  43 44-49
  • 12 Foroutani A, Garland A M, Berber E et al.. Laparoscopic ultrasound vs triphasic computed tomography for detecting liver tumors.  Arch Surg. 2000;  135 933-938
  • 13 Cervone A, Sardi A, Conaway G L. Intraoperative ultrasound (IOUS) is essential in the management of metastatic colorectal liver lesions.  Am Surg. 2000;  66 611-615
  • 14 Leen E, Angerson W J, Yarmenitis S et al.. Multi-centre clinical study evaluating the efficacy of SonoVue (BR1), a new ultrasound contrast agent in Doppler investigation of focal hepatic lesions.  Eur J Radiol. 2002;  41 200-206
  • 15 Beissert M, Delorme S, Mutze S et al.. Comparison of B-mode and conventional colour/power Doppler ultrasound, contrast-enhanced Doppler ultrasound and spiral CT in the diagnosis of focal lesions of the liver: results of a multicentre study.  Ultraschall Med. 2002;  23 245-250
  • 16 von Herbay A, Vogt C, Willers R, Haussinger D. Real-time imaging with the sonographic contrast agent SonoVue: differentiation between benign and malignant hepatic lesions.  J Ultrasound Med. 2004;  23 1557-1568
  • 17 Quaia E, D'Onofrio M, Palumbo A, Rossi S, Bruni S, Cova M. Comparison of contrast-enhanced ultrasonography versus baseline ultrasound and contrast-enhanced computed tomography in metastatic disease of the liver: diagnostic performance and confidence.  Eur Radiol. 2006;  16 1599-1609
  • 18 Leen E, Ceccotti P, Kalogeropoulou C, Angerson W J, Moug S J, Horgan P G. Prospective multicenter trial evaluating a novel method of characterizing focal liver lesions using contrast-enhanced sonography.  AJR Am J Roentgenol. 2006;  186 1551-1559
  • 19 Hollett M D, Jeffrey Jr R B, Nino-Murcia M, Jorgensen M J, Harris D P. Dual-phase helical CT of the liver: value of arterial phase scans in the detection of small (< or = 1.5 cm) malignant hepatic neoplasms.  AJR Am J Roentgenol. 1995;  164 879-884
  • 20 Oliver III J H, Baron R L, Federle M P, Rockette Jr H E. Detecting hepatocellular carcinoma: value of unenhanced or arterial phase CT imaging or both used in conjunction with conventional portal venous phase contrast-enhanced CT imaging.  AJR Am J Roentgenol. 1996;  167 71-77
  • 21 Yeh B M, Breiman R S, Taouli B, Qayyum A, Roberts J P, Coakley F V. Biliary tract depiction in living potential liver donors: comparison of conventional MR, mangafodipir trisodium-enhanced excretory MR, and multi-detector row CT cholangiography-initial experience.  Radiology. 2004;  230 645-651
  • 22 Wang Z J, Yeh B M, Roberts J P, Breiman R S, Qayyum A, Coakley F V. Living donor candidates for right hepatic lobe transplantation: evaluation at CT cholangiography-initial experience.  Radiology. 2005;  235 899-904
  • 23 Matsui O, Takashima T, Kadoya M et al.. Liver metastases from colorectal cancers: detection with CT during arterial portography.  Radiology. 1987;  165 65-69
  • 24 Heiken J P, Weyman P J, Lee J K et al.. Detection of focal hepatic masses: prospective evaluation with CT, delayed CT, CT during arterial portography, and MR imaging.  Radiology. 1989;  171 47-51
  • 25 Kondo H, Kanematsu M, Hoshi H et al.. Preoperative detection of malignant hepatic tumors: comparison of combined methods of MR imaging with combined methods of CT.  AJR Am J Roentgenol. 2000;  174 947-954
  • 26 Semelka R C, Martin D R, Balci C, Lance T. Focal liver lesions: comparison of dual-phase CT and multisequence multiplanar MR imaging including dynamic gadolinium enhancement.  J Magn Reson Imaging. 2001;  13 397-401
  • 27 Rode A, Bancel B, Douek P et al.. Small nodule detection in cirrhotic livers: evaluation with US, spiral CT, and MRI and correlation with pathologic examination of explanted liver.  J Comput Assist Tomogr. 2001;  25 327-336
  • 28 Libbrecht L, Bielen D, Verslype C et al.. Focal lesions in cirrhotic explant livers: pathological evaluation and accuracy of pretransplantation imaging examinations.  Liver Transpl. 2002;  8 749-761
  • 29 Burrel M, Llovet J M, Ayuso C et al.. MRI angiography is superior to helical CT for detection of HCC prior to liver transplantation: an explant correlation.  Hepatology. 2003;  38 1034-1042
  • 30 Soyer P, de Givry S C, Gueye C, Lenormand S, Somveille E, Scherrer A. Detection of focal hepatic lesions with MR imaging: prospective comparison of T2-weighted fast spin-echo with and without fat suppression, T2-weighted breath-hold fast spin-echo, and gadolinium chelate-enhanced 3D gradient-recalled imaging.  AJR Am J Roentgenol. 1996;  166 1115-1121
  • 31 Fujita T, Ito K, Honjo K, Okazaki H, Matsumoto T, Matsunaga N. Detection of hepatocellular carcinoma: comparison of T2-weighted breath-hold fast spin-echo sequences and high-resolution dynamic MR imaging with a phased-array body coil.  J Magn Reson Imaging. 1999;  9 274-279
  • 32 Coulam C H, Chan F P, Li K C. Can a multiphasic contrast-enhanced three-dimensional fast spoiled gradient-recalled echo sequence be sufficient for liver MR imaging?.  AJR Am J Roentgenol. 2002;  178 335-341
  • 33 Hecht E M, Holland A E, Israel G M et al.. Hepatocellular carcinoma in the cirrhotic liver: gadolinium-enhanced 3D T1-weighted MR imaging as a stand-alone sequence for diagnosis.  Radiology. 2006;  239 438-447
  • 34 Sodickson A, Mortele K J, Barish M A, Zou K H, Thibodeau S, Tempany C M. Three-dimensional fast-recovery fast spin-echo MRCP: comparison with two-dimensional single-shot fast spin-echo techniques.  Radiology. 2006;  238 549-559
  • 35 Kapoor V, Peterson M S, Baron R L, Patel S, Eghtesad B, Fung J J. Intrahepatic biliary anatomy of living adult liver donors: correlation of mangafodipir trisodium-enhanced MR cholangiography and intraoperative cholangiography.  AJR Am J Roentgenol. 2002;  179 1281-1286
  • 36 Bridges M D, May G R, Harnois D M. Diagnosing biliary complications of orthotopic liver transplantation with mangafodipir trisodium-enhanced MR cholangiography: comparison with conventional MR cholangiography.  AJR Am J Roentgenol. 2004;  182 1497-1504
  • 37 Goyen M, Schroeder T, Ruehm S G, Debatin J F. MR-based assessment of potential living related liver donors.  Eur Radiol. 2004;  14(suppl 7) O36-O40
  • 38 Akin E B, Vitellas K M, Rajab A et al.. Magnetic resonance cholangiography with mangafodipir trisodium (Teslascan) to evaluate bile duct leaks after T-tube removal in liver transplantation.  J Comput Assist Tomogr. 2004;  28 613-616
  • 39 Ayuso J R, Ayuso C, Bombuy E et al.. Preoperative evaluation of biliary anatomy in adult live liver donors with volumetric mangafodipir trisodium enhanced magnetic resonance cholangiography.  Liver Transpl. 2004;  10 1391-1397
  • 40 Lee V S, Krinsky G A, Nazzaro C A et al.. Defining intrahepatic biliary anatomy in living liver transplant donor candidates at mangafodipir trisodium-enhanced MR cholangiography versus conventional T2-weighted MR cholangiography.  Radiology. 2004;  233 659-666
  • 41 Lim J S, Kim M J, Kim J H et al.. Preoperative MRI of potential living-donor-related liver transplantation using a single dose of gadobenate dimeglumine.  AJR Am J Roentgenol. 2005;  185 424-431
  • 42 Moseley M E, Cohen Y, Mintorovitch J et al.. Early detection of regional cerebral ischemia in cats: comparison of diffusion- and T2-weighted MRI and spectroscopy.  Magn Reson Med. 1990;  14 330-346
  • 43 Taouli B, Vilgrain V, Dumont E, Daire J L, Fan B, Menu Y. Evaluation of liver diffusion isotropy and characterization of focal hepatic lesions with two single-shot echo-planar MR imaging sequences: prospective study in 66 patients.  Radiology. 2003;  226 71-78
  • 44 Quan X Y, Sun X J, Yu Z J, Tang M. Evaluation of diffusion weighted imaging of magnetic resonance imaging in small focal hepatic lesions: a quantitative study in 56 cases.  Hepatobiliary Pancreat Dis Int. 2005;  4 406-409
  • 45 Sun X J, Quan X Y, Huang F H, Xu Y K. Quantitative evaluation of diffusion-weighted magnetic resonance imaging of focal hepatic lesions.  World J Gastroenterol. 2005;  11 6535-6537
  • 46 Nasu K, Kuroki Y, Nawano S et al.. Hepatic metastases: diffusion-weighted sensitivity-encoding versus SPIO-enhanced MR imaging.  Radiology. 2006;  239 122-130
  • 47 Boulanger Y, Amara M, Lepanto L et al.. Diffusion-weighted MR imaging of the liver of hepatitis C patients.  NMR Biomed. 2003;  16 132-136
  • 48 Koinuma M, Ohashi I, Hanafusa K, Shibuya H. Apparent diffusion coefficient measurements with diffusion-weighted magnetic resonance imaging for evaluation of hepatic fibrosis.  J Magn Reson Imaging. 2005;  22 80-85
  • 49 Ross B D, Moffat B A, Lawrence T S et al.. Evaluation of cancer therapy using diffusion magnetic resonance imaging.  Mol Cancer Ther. 2003;  2 581-587
  • 50 Chen C Y, Li C W, Kuo Y T et al.. Early response of hepatocellular carcinoma to transcatheter arterial chemoembolization: choline levels and MR diffusion constants-initial experience.  Radiology. 2006;  239 448-456
  • 51 Jackson A, Haroon H, Zhu X P, Li K L, Thacker N A, Jayson G. Breath-hold perfusion and permeability mapping of hepatic malignancies using magnetic resonance imaging and a first-pass leakage profile model.  NMR Biomed. 2002;  15 164-173
  • 52 Annet L, Materne R, Danse E, Jamart J, Horsmans Y, Van Beers B E. Hepatic flow parameters measured with MR imaging and Doppler US: correlations with degree of cirrhosis and portal hypertension.  Radiology. 2003;  229 409-414
  • 53 Yoshioka H, Takahashi N, Yamaguchi M, Lou D, Saida Y, Itai Y. Double arterial phase dynamic MRI with sensitivity encoding (SENSE) for hypervascular hepatocellular carcinomas.  J Magn Reson Imaging. 2002;  16 259-266
  • 54 Tanoli T, Yue P, Yablonskiy D, Schonfeld G. Fatty liver in familial hypobetalipoproteinemia: roles of the APOB defects, intra-abdominal adipose tissue, and insulin sensitivity.  J Lipid Res. 2004;  45 941-947
  • 55 Machann J, Thamer C, Schnoedt B et al.. Hepatic lipid accumulation in healthy subjects: a comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopy.  Magn Reson Med. 2006;  55 913-917
  • 56 Cho S G, Kim M Y, Kim H J et al.. Chronic hepatitis: in vivo proton MR spectroscopic evaluation of the liver and correlation with histopathologic findings.  Radiology. 2001;  221 740-746
  • 57 Lim A K, Patel N, Hamilton G, Hajnal J V, Goldin R D, Taylor-Robinson S D. The relationship of in vivo 31P MR spectroscopy to histology in chronic hepatitis C.  Hepatology. 2003;  37 788-794
  • 58 Dezortova M, Taimr P, Skoch A, Spicak J, Hajek M. Etiology and functional status of liver cirrhosis by 31P MR spectroscopy.  World J Gastroenterol. 2005;  11 6926-6931
  • 59 Zakian K L, Koutcher J A, Malhotra S et al.. Liver regeneration in humans is characterized by significant changes in cellular phosphorus metabolism: assessment using proton-decoupled 31P-magnetic resonance spectroscopic imaging.  Magn Reson Med. 2005;  54 264-271
  • 60 Chu W C, Lam W W, Lee K H, Yeung D K, Sihoe J, Yeung C K. Phosphorus-31 MR spectroscopy in pediatric liver transplant recipients: a noninvasive assessment of graft status with correlation with liver function tests and liver biopsy.  AJR Am J Roentgenol. 2005;  184 1624-1629
  • 61 Planchamp C, Montet X, Frossard J L et al.. Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers.  Invest Radiol. 2005;  40 187-194
  • 62 Matsuo M, Kanematsu M, Itoh K et al.. Detection of malignant hepatic tumors: comparison of gadolinium- and ferumoxide-enhanced MR imaging.  AJR Am J Roentgenol. 2001;  177 637-643
  • 63 Kwak H S, Lee J M, Kim Y K, Lee Y H, Kim C S. Detection of hepatocellular carcinoma: comparison of ferumoxides-enhanced and gadolinium-enhanced dynamic three-dimensional volume interpolated breath-hold MR imaging.  Eur Radiol. 2005;  15 140-147
  • 64 Simon G, Link T M, Wortler K et al.. Detection of hepatocellular carcinoma: comparison of Gd-DTPA- and ferumoxides-enhanced MR imaging.  Eur Radiol. 2005;  15 895-903
  • 65 Kato H, Kanematsu M, Kondo H et al.. Ferumoxide-enhanced MR imaging of hepatocellular carcinoma: correlation with histologic tumor grade and tumor vascularity.  J Magn Reson Imaging. 2004;  19 76-81
  • 66 Kim Y K, Lee J M, Kim C S, Chung G H, Kim C Y, Kim I H. Detection of liver metastases: gadobenate dimeglumine-enhanced three-dimensional dynamic phases and one-hour delayed phase MR imaging versus superparamagnetic iron oxide-enhanced MR imaging.  Eur Radiol. 2005;  15 220-228
  • 67 Bartolozzi C, Donati F, Cioni D et al.. Detection of colorectal liver metastases: a prospective multicenter trial comparing unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT.  Eur Radiol. 2004;  14 14-20
  • 68 Youk J H, Lee J M, Kim C S. MRI for detection of hepatocellular carcinoma: comparison of mangafodipir trisodium and gadopentetate dimeglumine contrast agents.  AJR Am J Roentgenol. 2004;  183 1049-1054
  • 69 Scharitzer M, Schima W, Schober E et al.. Characterization of hepatocellular tumors: value of mangafodipir-enhanced magnetic resonance imaging.  J Comput Assist Tomogr. 2005;  29 181-190
  • 70 Sahani D V, Kalva S P, Fischman A J et al.. Detection of liver metastases from adenocarcinoma of the colon and pancreas: comparison of mangafodipir trisodium-enhanced liver MRI and whole-body FDG PET.  AJR Am J Roentgenol. 2005;  185 239-246
  • 71 Regge D, Campanella D, Anselmetti G C et al.. Diagnostic accuracy of portal-phase CT and MRI with mangafodipir trisodium in detecting liver metastases from colorectal carcinoma.  Clin Radiol. 2006;  61 338-347
  • 72 Gondolesi G E, Yoshizumi T, Bodian C et al.. Accurate method for clinical assessment of right lobe liver weight in adult living-related liver transplant.  Transplant Proc. 2004;  36 1429-1433
  • 73 Harada N, Shimada M, Yoshizumi T, Suehiro T, Soejima Y, Maehara Y. A simple and accurate formula to estimate left hepatic graft volume in living-donor adult liver transplantation.  Transplantation. 2004;  77 1571-1575
  • 74 Salvalaggio P R, Baker T B, Koffron A J et al.. Liver graft volume estimation in 100 living donors: measure twice, cut once.  Transplantation. 2005;  80 1181-1185
  • 75 Dodd III G D, Baron R L, Oliver III J H, Federle M P. Spectrum of imaging findings of the liver in end-stage cirrhosis: part II, focal abnormalities.  AJR Am J Roentgenol. 1999;  173 1185-1192
  • 76 Krinsky G A, Israel G. Nondysplastic nodules that are hyperintense on T1-weighted gradient-echo MR imaging: frequency in cirrhotic patients undergoing transplantation.  AJR Am J Roentgenol. 2003;  180 1023-1027
  • 77 Yu J S, Kim Y H, Rofsky N M. Dynamic subtraction magnetic resonance imaging of cirrhotic liver: assessment of high signal intensity lesions on nonenhanced T1-weighted images.  J Comput Assist Tomogr. 2005;  29 51-58
  • 78 Sugiyama M, Sakahara H, Torizuka T et al.. 18F-FDG PET in the detection of extrahepatic metastases from hepatocellular carcinoma.  J Gastroenterol. 2004;  39 961-968

Emil CohenM.D. 

Department of Radiology, Box 1234, Mount Sinai Medical Center, One Gustave L. Levy Place

New York, NY 10029-6574

Email: emil.cohen@mountsinai.org

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