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Planta Med 1997; 63(5): 409-414
DOI: 10.1055/s-2006-957723
Papers
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Rutoside as Mucosal Protective in Acetic Acid-Induced Rat Colitis

J. Gálvez, T. Cruz, E. Crespo, M. A. Ocete, M. D. Lorente, F. Sánchez de Medina, A. Zarzuelo
  • Department of Pharmacology, School of Pharmacy, University of Granada, Polígono de Cartuja s/n, E-18071 Granada, Spain
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Publication History

1996

1997

Publication Date:
04 January 2007 (online)

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Abstract

The effect of the flavonoid rutoside on acetic acid-induced rat colitis was studied. Rats were pretreated orally with different doses of the flavonoid (10, 25, and l00 mg/kg) 48, 24, and 1 hour prior to colitis induction and examined for colonic damage 24 hours later. Colonic inflammation was characterized by gross and microscopical injury, bowel wall thickening, abolition of fluid absorption, glutathione depletion, enhanced leukotriene B4 synthesis, and increased levels of myeloperoxidase and alkaline phosphatase activities. Rutoside treatment (25 and 100 mg/kg) reduced histologic injury and prevented the increase in alkaline phosphatase activity, but it had no effect on myeloperoxidase levels or leukotriene B4 synthesis. In addition, glutathione depletion was effectively counteracted at the dose of 25 mg/kg, whereas fluid absorption was achieved at the highest dose assayed. It is concluded that rutoside has an acute anti-inflammatory activity in this model which may be related to a putative direct protective effect on intestinal cells, mainly enterocytes, in which the antioxidative properties of the flavonoid may play a role.

key words

Rutoside - acetic acid rat colitis - intestinal anti-inflammatory activity - antioxidative activity

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