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Planta Med 1994; 60(2): 163-167
DOI: 10.1055/s-2006-959442
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© Georg Thieme Verlag Stuttgart · New York

Biologically Active Triterpene Saponins from Bupleurum fruticosum

M. C. Guinea1 , J. Parellada1 , M. A. Lacaille-Dubois2 , H. Wagner3
  • 1Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Alcalá de Henares, E-28871 Alcalá de Henares, Madrid, Spain
  • 2Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Bourgogne, F-21033 Dijon Cedex, France
  • 3Institut für Pharmazeutische Biologie der Universität München, Karlstraße 29, D-80333 München, Federal Republic of Germany
Further Information

Publication History

1993

1993

Publication Date:
04 January 2007 (online)

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Abstract

Extracts of the root of B. fruticosum L. showed in a biological Screening hemolytical activity, hepatoprotective and phagocytosis stimiilating effects, and a specific inhibitory activity of leucine amino-peptidase. Further monitoring of the fraction with antihepatotoxic activity led to the isolation of an hepatoprotective saikosaponin identified as buddlejasaponin IV and the new malonylbuddlejasaponin IV, determined as saikogenin F-3-O-[6-O-malonyl-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl(1→3)]-β-D-fucopyranoside. The structures were elucidated on the basis of the chemical and spectroscopic data.

Key words

Bupleurum fruticosum - Apiaceae - saikosaponin - malonylsaikosaponin - antihepatotoxic activity - granulocyte phagocytosis Stimulation - leucine aminopeptidase inhibition

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