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Planta Med 1994; 60(3): 228-231
DOI: 10.1055/s-2006-959464
Paper

© Georg Thieme Verlag Stuttgart · New York

Anti-Inflammatory Activity of Hydroxyachillin, a Sesquiterpene Lactone from Tanacetum microphyllum

M. J. Abad1 , P. Bermejo1 , S. Valverde2 , A. Villar1
  • 1Department of Pharmacology, Faculty of Pharmacy, University Complutense, E-28040 Madrid, Spain
  • 2Institute of Organic Chemistry, CSIC, Juan de la Cierva 3, E-28002 Madrid, Spain
Further Information

Publication History

1993

1993

Publication Date:
04 January 2007 (online)

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Abstract

The aerial parts of Tanacetum microphyllum D.C. (Compositae), used in folk medicine as an anti-inflammatory and anti-ulcer agent, were studied, the active principle hydroxyachillin (1) was isolated, and its pharmacological properties were analyzed. Hydroxyachillin showed marked anti-inflammatory activity in carrageenan-induced paw edema in mice. In the experimental models in vitro, hydroxyachillin has been reported to be a dual inhibitor of cyclooxygenase and soybean lipoxygenase. In this study, inhibition of prostaglandin synthetase (bovine seminal vesicular microsomes) by hydroxyachillin required concentrations more than twice those which inhibited soybean lipoxygenase (ED50 values = 10-4 M and 2.6 × 10-5 M, respectively). Therefore, an inhibition of leukotriene synthesis might be involved in the anti-inflammatory activity of hydroxyachillin in vivo.

Key words

Tanacetum microphyllum - Compositae - sesquiterpene lactones - hydroxyachillin - anti-inflammatory activity - soybean lipoxygenase - prostaglandin synthetase

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