Antimalarial Activity and Cytotoxicity of (-)-Roemrefidine Isolated from the Stem Bark of Sparattanthelium amazonum

V. Muñoz; M. Sauvain; P. Mollinedo; J. Callapa; I. Rojas; A. Gimenez; A. Valentin; M. Mallié

doi:10.1055/s-2006-960808

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Planta Med 1999; 65(5): 448-449
DOI: 10.1055/s-2006-960808

Letter

Antimalarial Activity and Cytotoxicity of (-)-Roemrefidine Isolated from the Stem Bark of Sparattanthelium amazonum

V. Muñoz¹ , M. Sauvain² , P. Mollinedo¹ , J. Callapa¹ , I. Rojas¹ , A. Gimenez³ , A. Valentin⁴ , M. Mallié⁴

¹Instituto Boliviano de Biologia de Altura, La Paz, Bolivia
²Institut de Recherche pour le Développement, Paris, France
³Instituto de Investigaciones Farmaco-Bioquímicas, Universidad Mayor de San Andrés, La Paz, Bolivia
⁴Laboratoire d'lmmunologie et Parasitologie, UFR Sciences Pharmaceutiques, Montpellier, France

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Publication History

1998

1999

Publication Date:
04 January 2007 (online)

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Abstract

(-)-Roemrefidine, an aporphine alkaloid isolated from Sparattanthelium amazonum Martius (Hernandiaceae) a vine from Bolivia, has been found to be active against both resistant and sensitive strains of Plasmodium falciparum in vitro and against P. berghei in mice. The compound demonstrated no cytotoxic activity against three cell lines (KB, HEp-2 and HeLa).

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