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Planta Med 1999; 65(5): 460-462
DOI: 10.1055/s-2006-960813
Letter

© Georg Thieme Verlag Stuttgart · New York

(-)-Epiafzelechin: Cyclooxygenase-1 Inhibitor and Anti-Inflammatory Agent from Aerial Parts of Celastrus orbiculatus

Kyung Rak Min1 , Bang Yeon Hwang1 , Hyoun-Soo Lim1 , Bo-Seong Kang1 , Gab-Jin Oh1 , Jeongrai Lee1 , Seh-Hoon Kang2 , Kyong Soon Lee1 , Jai Seup Ro1 , Youngsoo Kim1
  • 1College of Pharmacy, Chungbuk National University, Cheongju, Korea
  • 2Cosmetic R & D Center, LG Chemical Ltd. Taejon, Korea
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Publication History

1998

1999

Publication Date:
04 January 2007 (online)

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Abstract

An inhibitor of cyclooxygenase (COX)-1 activity of prostaglandin H2 synthase was isolated from aerial parts of Celastrus orbiculatus Thunb. (Celastraceae), an oriental folk medicine for rheumatoid arthritis by activity-guided column chromatographic methods. The COX inhibitor was identified as (-)-epiafzelechin, a member of flavan-3-ols by the structural analysis with HR-EI-mass, 1H-NMR and 13C-NMR spectral data. The compound exhibited a dose-dependent inhibition on the COX activity with an IC50 value of 15 µM. (-)-Epiafzelechin exhibited about 3-fold weaker inhibitory potency on the enzyme activity than indomethacin as a positive control. (-)-Epiafzelechin exhibited significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment.

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