Neuropediatrics 2007; 38(5): 257-260
DOI: 10.1055/s-2007-1004521
Short Communication

© Georg Thieme Verlag KG Stuttgart · New York

Detection of Autoantibodies against NMDA-Type Glutamate Receptor in a Patient with Recurrent Optic Neuritis and Transient Cerebral Lesions

N. Ishikawa 1 , G. Tajima 1 , S. Hyodo 2 , Y. Takahashi 3 , M. Kobayashi 1
  • 1Department of Pediatrics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
  • 2Department of Pediatrics, Funairi Municipal Hospital, Hiroshima, Japan
  • 3Department of Pediatrics, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
Further Information

Publication History

received 11.07.2007

accepted 06.11.2007

Publication Date:
10 March 2008 (online)

Abstract

We describe the case of a Japanese girl with recurrent optic neuritis and transient cerebral lesions. Antibodies against N-methyl-d-aspartate (NMDA)-type glutamate receptors were detected in both serum and cerebrospinal fluid. Results of this case study suggest that the development of autoantibodies against NMDA-type glutamate receptors may play a role in the pathogenesis of central nervous system demyelinating diseases.

References

  • 1 Backhoff F, Fillipi M, Miller DH, Scheltens P, Campi A, Polman CH. et al . Comparison of MR imaging criteria at first presentation to predict conversion to clinically definite multiple sclerosis.  Brain. 1997;  120 2059-2069
  • 2 Fazekas F, Deisenhammer F, Strasser-Fuchs S, Nahler G, Mamoli B. Randomized placebo-controlled trial of monthly intravenous immunoglobulin therapy in relapsing-remitting multiple sclerosis.  Lancet. 1997;  349 589-593
  • 3 Krupp LB, Banwell B, Tenembaum S. Consensus definitions proposed for pediatric multiple sclerosis and related disorders.  Neurol. 2007;  68 ((suppl 2)) S7-S12
  • 4 McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD. et al . Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis.  Ann Neurol. 2001;  50 121-127
  • 5 Reindl M, Khalil M, Berger T. Antibodies as biological markers for pathophysiological process in MS.  J Neuroimmunol. 2006;  180 50-62
  • 6 Steinman L. Multiple sclerosis: a two-stage disease.  Nat Immunol. 2001;  2 762-764
  • 7 Takahashi Y. Infections as causative factors of epilepsy.  Future Neurol. 2006;  1 291-302
  • 8 Takahashi Y, Mori H, Mishima M, Watanabe M, Fujiwara T, Shimomura J. et al . Autoantibodies to NMDA receptor in patients with chronic forms of epilepsia partialis continua.  Neurology. 2003;  61 891-896
  • 9 Takahashi Y, Mori H, Mishima M, Watanabe M, Kondo N, Shimomura J. et al . Autoantibodies and cell mediated autoimmunity to NMDA-type GluRå2 in patients with Rasmussen's encephalitis and chro-nic progressive epilepsia partialis continua.  Epilepsia. 2005;  46 152-158
  • 10 Tintore M, Rovira A, Martinez MJ, Rio J, Diaz-Villoslada P, Brieva L. et al . Isolated demyelinating syndromes: Comparison of different MR imaging criteria to predict conversion clinically definite multiple sclerosis.  Am J Neuroradiol. 2000;  21 702-706

Correspondence

N. IshikawaMD. 

Department of Pediatrics

Hiroshima University Graduate School of Biomedical Science

1-2-3 Kasumi

Minami-ku

734-8551 Hiroshima

Japan

Phone: +81/82/257 52 12

Fax: +81/82/257 52 14

Email: ishikan@hiroshima-u.ac.jp

    >