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Horm Metab Res 1987; 19(12): 642-647
DOI: 10.1055/s-2007-1011899
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Polymorphonuclear Cell Derangements in Type I Diabetes

D. Tater, B. Tepaut, J. P. Bercovici, P. Youinou
  • Unit of Diabetology and Laboratory of Immunology, Centre Hospitalier Universitaire, Brest, France
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Publication History

1986

1987

Publication Date:
14 March 2008 (online)

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Summary

Polymorphonuclear cell function had been studied in 58 Type I diabetic subjects. Chemotaxis, phagocytosis, adherence, bactericidal activity, NBT reduction capacity were evaluated. We enumerated gamma Fc receptor bearing Polymorphonuclear cells and the percentage of immune complexes containing Polymorphonuclear cells. These data were studied in accordance with glycemic levels and the presence of infections.

All Polymorphonuclear functions were decreased compared to non-diabetic subjects with the exception of phagocytosis. The efficiency of the diabetic sera on normal subjects polymorphonuclear cells was decreased (bactericidal activity, chemotactic index and phagocytosis).

These abnormalities were independent of the presence of infection. No correlation was found with glycemic level. The percentage of cells bearing an Fc gamma receptor was less in diabetics than in normal (70.1±17.4 vs 80.2±7.8%). The percentage of immune complexes containing polymorphonuclear cells was increased (n=16, 9.06±4.7 vs 4.75±2.1% in normals). There again, these data are without correlation with the presence of infections or glycemic level.

Key-Words

Diabetes - Immunology - Polymorphonuclear Cells - Fc Gamma Receptor

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