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Endoscopy 1986; 18(5): 174-176
DOI: 10.1055/s-2007-1018365
© Georg Thieme Verlag KG Stuttgart · New York

The Clinical Significance of Gastric Epithelial Dysplasia

H. Aste, S. Sciallero, V. Pugliese, M. Gennaro
  • Endoscopic Service and Gastrointestinal Unit, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy and the Institute of Oncology, University of Genoa, Genoa, Italy
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Publication History

Publication Date:
17 March 2008 (online)

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Summary

Six-hundred-and-ninety-four patients with localized gastric lesions (ulcers, polyps, enlarged or irregular folds, erosions and tumors) underwent endoscopic examination and multiple biopsies. Twenty-nine proved to have severe or moderate gastric epithelial dysplasia. Another group of 123 patients were submitted to endoscopic examination and multiple biopsies, but showed no evidence of localized gastric lesions. Only one case of mild dysplasia was observed in this group. Of the 29 patients with dysplasia, 8 (27.5 %) had a carcinoma in the surgical specimen. The endoscopic follow-up carried out in non-operated patients with dysplasia did not show any development of malignancy.

This study shows dysplastic changes significantly associated with prominent or depressed lesions of the gastric mucosa at endoscopy. In operated patients a synchronous carcinoma is often detected in the surgical specimen.

Key words:

Gastric dysplasia - Brush cytology - Gastric biopsy - Gastric cancer

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