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Horm Metab Res 1983; 15(9): 449-452
DOI: 10.1055/s-2007-1018751
© Georg Thieme Verlag, Stuttgart · New York

Experimental Hyperthyroidism in Man: Effects on Plasma Lipoproteins, Lipoprotein Lipase and Hepatic Lipase

P. Hansson, S. Valdemarsson1 , P. Nilsson-Ehle
  • Department of Clinical Chemistry, University Hospital, Lund, Sweden
  • 1Department of Internal Medicine, University Hospital, Lund, Sweden
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Publication History

1982

1982

Publication Date:
14 March 2008 (online)

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Summary

We have studied the effects of triiodothyronine administration (20-40 μg three times daily over one week) in six healthy young men, on the activities of lipoprotein lipase and hepatic lipase and on plasma lipoprotein concentrations. Hepatic lipase activity in post-heparin plasma rose by 46 ± 25% (p< 0.025), whereas the activity of lipoprotein lipase did not change significantly. Plasma cholesterol concentrations decreased by about 20% (p< 0.025), whereas there was no change in plasma triglyceride levels. The fall in plasma cholesterol could be accounted for by a reduction of HDL cholesterol (-11%, p< 0.025) as well as LDL cholesterol (-27%, p< 0.025). The data emphasize the role of hepatic lipase in the lipoprotein alterations associated with thyroid dysfunction.

Key-Words:

Hepatic Lipase - Hyperthyroidism - Lipoproteins - HDL - Lipoproteins - LDL - Lipoprotein Lipase - Triiodothyronine

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