Bioactive Phenols from the Leaves of Baccaurea ramiflora

 

 Buy Article Permissions and Reprints

Abstract

Two new phenols, 6′-O-vanilloylisotachioside (1) and 6′-O-vanilloyltachioside (2), together with nine known compounds, were isolated from the leaves of Baccaurea ramiflora (Euphorbiaceae). The structures of the new compounds were elucidated mainly by analysis of physical and spectroscopic data. Compounds 1 - 10 were tested for antioxidant activities by using MTT and DPPH assays. Seven compounds, 1, 2, and 4 - 8, revealed potent antioxidant activities against H₂O₂-induced impairment in PC12 cells, and exhibited significant DPPH radical-scavenging activities with IC₅₀ values of 86.9, 142.9, 15.2, 37.6, 35.9, 30.2, and 79.8 μM, respectively.

References

• 1 Li P T. Flora Reipublicae Popularis Sinicae. In: Wu ZY, editor Beijing; Science Press 1994: 131-3.
  Google Scholar
• 2 Lin Y F, Yi Z, Zhao Y H. Chinese Dai Medicine colorful illustrations. Kunming; Yunnan Nationality Press 2003: 158-60.
  Google Scholar
• 3 Foo L Y, Lu Y, McNabb W C, Waghorn G, Ulyatt M J. Proanthocyanidins from Lotus pedunculatus .  Phytochemistry. 1997;  45 1689-96.
  CrossrefPubMedGoogle Scholar
• 4 Kiatgrajai P, Wellons J D, Gollob L, White J D. Kinetics of polymerization of (+)-catechin with formaldehyde.  J Org Chem. 1982;  47 2913-7.
  CrossrefPubMedGoogle Scholar
• 5 Kim Y G, Lee H, Ozawa S, Sasaya T, Moon C K. Lignans of Abies koreana Wilson.  Mokuzai Gakkaishi. 1994;  40 414-8.
  PubMedGoogle Scholar
• 6 Kweon M H, Hwang H J, Sung H C. Identification and antioxidant avtivity of novel chlorogenic acid derivatives from Bamboo (Phyllostachys edulis).  J Agric Food Chem. 2001;  49 4646-55.
  CrossrefPubMedGoogle Scholar
• 7 Nakatani N, Kayano S, Kikuzaki H, Sumino K, Katagiri K, Mitani T. Identification, quantitative determination, and antioxidative activities of chlorogenic acid isomers in prune (Prunus domestica L. ).  J Agric Food Chem. 2000;  48 5512-6.
  CrossrefPubMedGoogle Scholar
• 8 Wang M, Kikuzaki H, Zhu N, Sang S, Nakatani N, Ho C T. Isolation and structural elucidation of two new glycosides from sage (Salvia officinalis L.)  J Agric Food Chem. 2000;  48 235-8.
  CrossrefPubMedGoogle Scholar
• 9 Simko I, Omer E A, Ewing E E, McMurry S, Koch J L, Davies P J. Tuberonic (12-OH-jasmonic) acid glucoside and its methyl ester in potato.  Phytochemistry. 1996;  43 727-30.
  CrossrefPubMedGoogle Scholar
• 10 Yue J, Lin Z, Wang D, Sun H. A sesquiterpene and other constituents from Erigron breviscapus .  Phytochemistry. 1994;  36 717-9.
  CrossrefPubMedGoogle Scholar
• 11 Inoshiri S, Sasaki M, Kohda H, Otsuka H, Yamasaki K. Aromatic glycosides from Berchemia racemosa .  Phytochemistry. 1987;  26 2811-4.
  CrossrefPubMedGoogle Scholar
• 12 Yang X W, Zhao P J, Ma Y L, Xiao H T, Zuo Y Q, He H P. et al . Mixed lignan-neolignans from Tarenna attenuata .  J Nat Prod. 2007;  70 521-5.
  CrossrefPubMedGoogle Scholar

Prof. Dr. Xiao-Jiang Hao

Key Laboratory of Phytochemistry and Plant Resources in West China

Kunming Institute of Botany

Chinese Academy of Sciences

Kunming 650204

People’s Republic of China

Phone: +86-871-522-3263

Fax: +86-871-521-9684

Email: haoxj@mail.kib.ac.cn

• Supplementary Material