New Cytotoxic Diarylheptanoids from the Rhizomes of Alpinia officinarum

 

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Abstract

Bioassay-guided fractionation of the cytotoxic MeOH extract from the rhizomes of Alpinia officinarum Hance led to the isolation of two new diarylheptanoids named alpinoid D (1) and E (2), together with fifteen known diarylheptanoids (3 - 17). The structures of compounds 1 and 2 were elucidated on the basis of spectroscopic data and chemical evidence. The cytotoxic activity of the isolated diarylheptanoids was evaluated against the IMR-32 human neuroblastoma cell line. Among the tested compounds, 11, 12 and 14 exhibited the most potent activities with IC₅₀ values of 0.83, 0.23 and 0.11 μM, respectively.

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Prof. Dr. Ken Yasukawa

College of Pharmacy

Nihon University

7-7-1, Narashinodai

Funabashi-shi

Chiba 274-8555

Japan

Phone: +81-47-465-1107

Fax: +81-47-465-1107

Email: self-med@pha.nihon-u.ac.jp

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