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DOI: 10.1055/s-2008-1071573
© Georg Thieme Verlag KG Stuttgart · New York
Inherited or Acquired Disorders of Blood Coagulation in Children with Neurovascular Complications
Publication History
Publication Date:
15 May 2008 (online)
Abstract
Congenital or acquired disorders of hemostasis can cause thrombotic events in adults as well as in children. Recently, acute neurologic complications such as hemiparesis or transitory ischemic attacks (TIA) have been reported in patients with different disorders of hemostasis. In addition, the interaction between anionic antiphospholipid antibodies and inhibition of the coagulation have to be considered for these clinical manifestation. This review aims at putting the clinical and experimental data which are currently available for children into perspective.
Abbreviations
APA: antiphospholipid antibodies
AT III : antithrombin III
CLA: cardiolipin antibody
Ig: immunoglobulin
LA: lupus anticoagulant
PA: plasminogen activator inhibitor
PC: protein C
PCa: activated protein C
PS: protein S
PTT: partial thromboplastin time
Key words
Stroke - Coagulation - Antiphospholipid antibodies - Neurovascular disorders