General Obstetrics and Gynecology: GynecologyThe relationship among serum insulin-like growth factor-I, insulin-like growth factor-I gene polymorphism, and bone mineral density in postmenopausal women in Korea☆,☆☆
Section snippets
Subjects
This study included 300 postmenopausal Korean women aged 45 to 75 years who visited the Menopause Clinic of Seoul National University Hospital for bone mass examination and who agreed to participate in the study. All subjects had been without spontaneous menses for at least 1 year and underwent a careful physical examination and a medical history review. Blood glucose and hepatic and renal function were determined. Women who had undergone bilateral oophorectomy or women with current hepatic or
Allele frequencies in a dinucleotide repeat of IGF-I gene
Table I shows the allele frequency distribution in a dinucleotide repeat of the IGF-I gene.Fragment size(bp) CA repeats(n) Allele frequency n % 176 12 1 0.2 180 13 1 0.2 182 14 8 1.3 184 15 25 4.2 186 16 109 18.2 188 17 157 26.2 190 18 93 15.5 192 19 86 14.3 194 20 119 19.8 196 21 1 0.2 TOTAL 600 100.0
Comment
Many genes that were believed to be involved in BMD have been investigated,2, 3 but osteoporosis genes have yet to be defined. Recently, our results have suggested that circulating IGF components play an important endocrinologic role in the maintenance of bone.5 The present cross-sectional study shows that the IGF-I gene CA polymorphism does not affect serum levels of biochemical markers of bone turnover and that this polymorphism is one of the genetic factors that may affect circulating IGF-I
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Cited by (58)
Molecular basis of bone diseases
2018, Molecular Pathology: The Molecular Basis of Human DiseaseThe Insulin-Like Growth Factor System in Bone. Basic and Clinical Implications.
2012, Endocrinology and Metabolism Clinics of North AmericaCitation Excerpt :Linkage analysis in humans has also implicated the possible role of Igf1 gene as contributing to the bone mass.51,52 For example, CA-repeat promoter polymorphisms in the Igf1 gene have been shown to be associated with bone mass.53–55 However, the importance of CA-repeat polymorphisms needs to be clarified because some studies could not find any association between bone mineral density and this polymorphism in premenopausal Caucasian and African American women56 and in premenopausal Chinese women.57
Association between endometriosis and polymorphisms in insulin-like growth factors (IGFs) and IGF-I receptor genes in Korean women
2011, European Journal of Obstetrics and Gynecology and Reproductive BiologyCitation Excerpt :Although Cleveland et al. [12] have reported that women with the genotype lacking (CA) 19 repeat alleles have a significantly increased risk of breast cancer, the present study showed that the IGF-I (CA) repeat polymorphism was not related with endometriosis, an estrogen-dependent benign condition, as it is with breast cancer. Several studies were undertaken to evaluate the association between the IGF-I (CA) repeat polymorphism and circulating IGF-I levels, but the results have been conflicting, showing a decrease [15], an increase [16] and no change [17–19] in serum IGF-I levels among subjects carrying a (CA)19 repeat allele. As IGF levels were not measured in this study, whether circulating IGF levels are associated with the IGF-I polymorphism could not be confirmed.
Genetic determinants involved in the osteoporosis pathophysiology
2020, Current Pharmacogenomics and Personalized Medicine
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Supported by a grant of the Korea Health 21 Research and Development Project, Ministry of Health and Welfare, Republic of Korea (HMP-00-B-21000-0029).
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Reprint requests: Jung Gu Kim, MD, PhD, Department of Obstetrics & Gynecology, Seoul National University Hospital, 28 Yeungun-dong Chongno-Ku, Seoul 110-744, Korea. E-mail: [email protected]