Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Oral MedicineReliability of toluidine blue application in the detection of oral epithelial dysplasia and in situ and invasive squamous cell carcinomas*,**
Section snippets
Patients and methods
For this study 50 patients with PMELs and superficial oral ulcerations suggestive of malignancy were selected from those treated at the Oral Medicine Service, Faculty of Dentistry, Araraquara, São Paulo, Brazil, from August 1993 to May 1995 (n = 1957). Not included in this study were patients who refused to be submitted to biopsy (n = 21), those who abandoned treatment, or those who had clinically obvious invasive carcinomas or lesions without risk or suspicion of malignancy. Twenty-eight of
Results
Of the 50 patients studied, 34 were smokers (23 smoked paper cigarettes, 7 hand-rolled cigarettes, and 4 pipes), 13 regularly consumed alcohol, and 13 had related occupational activities that frequently exposed them to the sun. The clinical diagnosis of the oral lesions analyzed and the results of staining are presented in Table II.
Clinical diagnosis n (%) Toluidine blue + – Homogenous leukoplakia 12 (24) 2 10 Nonhomogenous leukoplakia 20 (40) 10 10
Discussion
The sample investigated in this study was composed of 86% PMELs and 14% superficial oral ulcerations suggestive of malignancy, differentiating this work from the majority of previous works, which include in their samples few PMELs and a large number of clinically suspected malignancies or typically benign lesions with no risk of malignancy. Individuals without lesions (control group) were not included in this study, because performance of biopsy in normal mucosa not containing stain retention
Acknowledgements
We are indebted to the “Mario A.S. Paino” Laboratory of Clinical Pathology.
References (28)
- et al.
In vivo staining test for delineation of oral intraepithelial neoplastic change: preliminary report
J Am Dent Assoc
(1964) - et al.
In vivo staining properties of oral cancer
Am J Surg
(1965) Final evaluation of tolonium chloride rinse for screening of high-risk patients with asymptomatic squamous carcinoma
J Am Dent Assoc
(1983)- et al.
Toluidine blue staining in the detection of oral precancerous and malignant lesions
Oral Surg
(1984) - et al.
Use of meta-analysis to evaluate tolonium chloride in oral cancer screening
Oral Surg Oral Med Oral Pathol
(1989) - et al.
The utility of toluidine blue application as a diagnostic aid in patients previously treated for upper oropharyngeal carcinoma
Oral Surg Oral Med Oral Pathol
(1997) - et al.
Lichenoid dysplasic: a distinct histopathologic entity
Oral Surg Oral Med Oral Pathol
(1985) - et al.
Candidal infection in oral lichen planus
Oral Surg Oral Med Oral Pathol
(1990) - et al.
The application of toluidine blue as a diagnostic adjunct in the detection of epithelial dysplasia
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
(1998) - et al.
Further appraisal of in vivo staining properties of oral cancer
Arch Surg
(1967)
The toluidine blue test in lesions of the oral cavity
Cancer J Clin
Toluidine blue test for detection of carcinoma of the oral cavity: an evaluation
J Surg Oncol
Toluidine blue staining of oral cancer and precancerous lesions
Indian J Med Res
Reevaluation of toluidine blue application as a diagnostic adjunct in the detection of asymptomatic oral squamous carcinoma: a continuing prospective study of oral cancer III
Cancer
Cited by (0)
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Supported by grants CNPq no. 523164/96-3 and FAPESP no. 96/5927-8.
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Reprint requests: Dr Mirian A. Onofre, Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara - UNESP, Rua Humaitá, 1680, Araraquara - São Paulo, Brazil, [email protected]