NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response

Journal of Biological Chemistry

Volume 287, Issue 31, 27 July 2012, Pages 25758-25769

Under a Creative Commons license

open access

Background: Switching from the acute early initiation to late adaptation response after TLR4 stimulation depends on SirT1.

Results: Switching from glucose to fatty acid oxidation between initiation and adaptation responses requires SirT6 and SirT1.

Conclusion: Bioenergy integrates metabolism and acute inflammation.

Significance: Understanding bioenergy shifts during inflammation may enable development of new therapies.

Bioenergetics

Biosensors

Macrophages

Metabolism

NAD

Sepsis

Sirtuins

HIF-1α

PGC-1

Acute Inflammation

^*: This work was supported, in whole or in part, by National Institutes of Health RO1 Grants AI-065791 and AI-079144 (to C. E. M.), K08 Grant GM086470 (to V. V.), and MO-1RR 007122 (to the Wake Forest University General Clinical Research Center). The research on human participants was endorsed by Wake Forest University Institutional Review Board protocol BG174. The animal sepsis model was approved by the Institutional Animal Care and Use Committee of the Wake Forest University School of Medicine.