Neurobiology
The Neural Cell Adhesion Molecules L1 and CHL1 Are Cleaved by BACE1 Protease in Vivo*

https://doi.org/10.1074/jbc.M112.377465Get rights and content
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Background: The function and physiological substrates of BACE1 remain largely unknown.

Results: Novel substrates for BACE1 were identified using large scale proteome analysis; L1 and CHL1 were validated in vivo.

Conclusion: L1 and CHL1 are physiological substrates for BACE1.

Significance: Identification of physiological substrates of BACE1 is important to understand its function and helps to predict potential side effects of BACE1 inhibitor drugs for Alzheimer disease.

Alzheimers Disease
Axon
Neurons
Protease
Proteomics
Axon Guidance
BACE1
CHL1
L1
Neural Adhesion

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*

This work was supported in part by IWT Flanders, the Fund for Scientific Research, Flanders, KU Leuven, a Methusalem grant from KU Leuven and the Flemish Government, the Foundation for Alzheimer Research (SAO/FRMA), the Interuniversity Attraction Poles Program of the Belgian Federal Science Policy Office, and Fundação para a Ciência e a Tecnologia (Portugal).

© 2012 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.