Journal of Biological Chemistry
Computational BiologyNovel Synthetic Biscoumarins Target Tumor Necrosis Factor-α in Hepatocellular Carcinoma in Vitro and in Vivo*
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This work was supported by grants from National University of Singapore (NUS) Academic Research Fund (Grant R-184-000-207-112) (to G. S.). This research was also supported by the University Grants Commission (41-257-2012-SR), Vision Group Science and Technology, and Department of Science and Technology (Grant SR/FT/LS-142/2012) (to Basappa).
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Both authors contributed equally to this work.
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Recipient of a Basic Scientific Research (BSR) fellowship from the University Grants Commission (UGC).
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Recipient of an INSPIRE fellowship from the Department of Science and Technology (DST).
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Present address: Dept. of Studies and Research in Biochemistry, Tumkur University, Tumkur 572 103.
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The abbreviations used are:
- HCC
hepatocellular carcinoma
- BIHC
3,3′-((2-butyl-5-chloro-1H-imidazol-4-yl)methylene)bis(4-hydroxy-2H-chromen-2-one)
- DSS
dextran sulfate sodium
- PARP
poly(ADP-ribose) polymerase
- MTT
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
- TG
thioglycolate
- DAI
disease activity index
- RO
reverse osmosis
- MPO
myeloperoxidase.