Journal of Biological Chemistry
Transcription, Chromatin, and EpigeneticsBCL-xL Is a Target Gene Regulated by Hypoxia-inducible Factor-1α*
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The abbreviations used are: HIF-1α, hypoxia-inducible factor 1; BCL-xL, BCL2L1 or BCL2-like 1; BNIP3, BCL2/adenovirus E1B 19-kDa interacting protein 3; CASP, caspase; EMSA, electrophoretic mobility shift assay; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GLUT-1, glucose transporter-1; HIF-KD, HIF-1α knock-down PC-3 cells; HRE, hypoxia-responsive element; IAP, inhibitor of apoptosis protein; Mcl-1, myeloid cell factor-1; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; NIX, BCL2/adenovirus E1B 19-kDa interacting protein 3-like; RNAi, RNA interference; siRNA, small interference RNA; TUNEL, terminal deoxynucleotidyltransferase-mediated dUTP digoxigenin nick end labeling; VEGF, vascular endothelial growth factor; PI3K, phosphatidylinositol 3-kinase; RT, reverse transcription; KD, knocked-down; CHAPS, 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic acid; CMV, cytomegalovirus.
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This work was supported by Natural Science Foundation of China Grants NSFC 30570692, 30871383, and 30800637, Ministry of Education PhD Program Fund 20060610053, and Postdoctoral Fund 20060401022 of China.
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Supported by National Basic Research Program of China Grant 2007CB947802.