Journal of Biological Chemistry
Mechanisms of Signal TransductionThe Effects of Amyloid Precursor Protein on Postsynaptic Composition and Activity*
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The abbreviations used are: AD, Alzheimer disease; APP, amyloid precursor protein; NMDA, N-methyl-d-aspartate; NMDAR, NMDA receptor; RNAi, RNA interference; PSD, postsynaptic density; mEPSC, miniature excitatory postsynaptic current; GFP, green fluorescent protein; siRNA, small interfering RNA; β-ME, β-mercaptoethanol; PBS, phosphate-buffered saline; DIV, day(s) in vitro; CGC, cerebellar granule cell; pF, picofarads.
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This work was supported, in whole or in part, by National Institutes of Health Grants AG14473 (to G. W. R.), NS48085 (to D. T. S. P.), NS047700 (to S. V.), AG12406 (to B. T. H.), AG032330 (to H. S. H.). This work is also supported by the Alzheimer’s Research Fund in memory of Bill and Marie Drach. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
The on-line version of this article (available at http://www.jbc.org) contains supplemental Figs. S1 and S2.
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Both of these authors contributed equally to this work.
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Present address: Neurodegeneration Research, GlaxoSmith Kline, Shanghai 201203, China.
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Investigator of the Howard Hughes Medical Institute.