Minireviews
Cellular and Physiological Roles for Phospholipase D1 in Cancer*

https://doi.org/10.1074/jbc.R114.576876Get rights and content
Under a Creative Commons license
open access

Phospholipase D enzymes have long been proposed to play multiple cell biological roles in cancer. With the generation of phospholipase D1 (PLD1)-deficient mice and the development of small molecule PLD-specific inhibitors, in vivo roles for PLD1 in cancer are now being defined, both in the tumor cells and in the tumor environment. We review here tools now used to explore in vivo roles for PLD1 in cancer and summarize recent findings regarding functions in angiogenesis and metastasis.

Cited by (0)

*

This work was supported, in whole or in part, by National Institutes of Health Grant GM100109 and a Carol Baldwin Breast Cancer Award (to M. A. F.). This is the second article in the Thematic Minireview Series “Phospholipase D and Cancer.”

2

The abbreviations used are:

    PLD

    phospholipase D

    PA

    phosphatidic acid

    Ptd

    phosphatidyl

    FIPI

    5-fluoro-2-indolyl des-chlorohalopemide

    MMP

    matrix metalloproteinase

    EMT

    epithelial-mesenchymal transformation

    VEGFR2

    VEGF receptor 2

    ENaC

    epithelial sodium channel.