Journal of Biological Chemistry
Volume 293, Issue 25, June 2018, Pages 9759-9769
Signal TransductionDifferential activities and mechanisms of the four R-spondins in potentiating Wnt/β-catenin signalingDistinct activities of RSPO1–4
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cell signaling
stem cells
7-helix receptor
Wnt signaling
beta-catenin (β-catenin)
LGR4
LGR5
organoids
R-spondin
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This work was supported in part by Cancer Prevention and Research Institute of Texas Grants RP160235 and RP170245 and the Janice D. Gordon endowment for bowel cancer research (to Q. J. L). Q. J. L. is a cofounder of Wntrix, and J. C. is a full-time employee of Wntrix.
This article contains Figs. S1–S6.
© 2018 Park et al.