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Higher erythrocyte 22: 6n−3 and 22: 5n−6, and lower 22: 5n−3 suggest higher Δ-4-desaturation capacity in women of childbearing age

Published online by Cambridge University Press:  09 March 2007

Ella N. Smit*
Affiliation:
Department of Pathology and Laboratory Medicine, CMC-V, Y1.147, Groningen University Hospital, PO Box 30.001, 9700 RB Groningen, The Netherlands
M. Rebecca Fokkema
Affiliation:
Department of Pathology and Laboratory Medicine, CMC-V, Y1.147, Groningen University Hospital, PO Box 30.001, 9700 RB Groningen, The Netherlands
E. Rudy Boersma
Affiliation:
Retired Professor of Paediatrics, Groningen University Hospital, The Netherlands
Frits A. J. Muskiet
Affiliation:
Department of Pathology and Laboratory Medicine, CMC-V, Y1.147, Groningen University Hospital, PO Box 30.001, 9700 RB Groningen, The Netherlands
*
*Corresponding Author: Dr Ella N. Smit, c/o Frits A. J. Muskiet, fax +31 50 3612290, email ella.smit@undp.org
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Abstract

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Type
Letter to the Editors
Copyright
Copyright © The Nutrition Society 2003

References

Burdge, GC, Jones, AE & Wootton, SA (2002) Eicosapentaenoic and docosapentaenoic acids are the principal products of α-linolenic acid metabolism in young men. British Journal of Nutrition 88 355363.CrossRefGoogle ScholarPubMed
Burdge, GC & Wootton, SA (2002) Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. British Journal of Nutrition 88 411420.CrossRefGoogle ScholarPubMed
Fokkema, MR, Smit, EN, Martini, IA, Woltil, HA, Boersma, ER & Muskiet, FAJ (2002) Assessment of essential fatty acid and omega 3-fatty acid status by measurement of erythrocyte 20:3ω9 (Mead acid), 22:5ω6/20:4ω6 and 22:5ω6/22:6ω3. Prostaglandins, Leukotrienes and Essential Fatty Acids 67 345356.CrossRefGoogle ScholarPubMed
Holman, RT, Smythe, L & Johnson, S (1979) Effect of sex and age on fatty acid composition of human serum lipids. American Journal of Clinical Nutrition 32 23902399.CrossRefGoogle ScholarPubMed
Horrobin, DF (1981) Loss of delta-6-desaturase activity as a key factor in aging. Medical Hypotheses 7 12111220.CrossRefGoogle ScholarPubMed
Horrobin, DF (1995) Abnormal membrane concentrations of 20 and 22-carbon essential fatty acids: A common link between risk factors and coronary and peripheral vascular disease? Prostaglandins, Leukotrienes and Essential Fatty Acids 53 385396.CrossRefGoogle ScholarPubMed
Sprecher, H, Chen, Q & Yin, FQ (1999) Regulation of the biosynthesis of 22:5n-6 and 22:6n-3: a complex intracellular process. Lipids 34 Suppl.S153S156.CrossRefGoogle Scholar