Synvisc perisynovitis
References (7)
- et al.
The role of viscosupplementation with hylan G-F 20 (Synvisc) in the treatment of osteoarthritis of the knee: a Canadian multicentre trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone
Osteoarthritis Cartilage
(1995) - et al.
Viscosupplementation with hylan G-F 20: a 26 week controlled trial of efficacy and safety in the osteoarthritis joint
Clin Ther
(1998) - et al.
A risk-benefit assessment of injections of hyaluronan and its derivatives in the treatment of osteoarthritis of the knee
Drug Saf
(2000)
Cited by (33)
Biocompatibility of cross-linked hyaluronate (Gel-200) for the treatment of knee osteoarthritis
2014, Osteoarthritis and CartilageCitation Excerpt :Synvisc-One was the first single injection product approved in the US and contains three times the volume of hylan G-F 20 as Synvisc, which requires three injections. However, there is growing clinical evidence to suggest that hylan G-F 20 may be associated with an increased incidence of pseudosepsis or granulomatous synovitis4–13. Furthermore, in non-clinical studies, evidence of an immune response to hylan G-F 20 has been demonstrated.
Advances and advantages of nanomedicine in the pharmacological targeting of hyaluronan-CD44 interactions and signaling in cancer
2014, Advances in Cancer ResearchThe Role of Viscosupplementation in the Ankle Using Hylan G-F 20
2008, Journal of Foot and Ankle SurgeryCitation Excerpt :Cases of post injection-induced pseudogout with hylan G-F 20 have also been reported (36, 43). Zardawi and Chan (44) observed granulomatous inflammation with hylan G-F 20 in the perisynovial adipose tissue and described the histological findings associated with the condition. Martens (45) described symmetrical knee inflammation after hyaluronan injection and suggested that some individuals may be uniquely susceptible to inflammatory responses.
A double-blind randomized controlled trial comparing alternate forms of high molecular weight hyaluronan for the treatment of osteoarthritis of the knee
2006, Osteoarthritis and CartilageCitation Excerpt :Several recent publications have noted acute local reactions after hylan CL-HA injection15,16, particularly in patients receiving repeat treatment17. Inflammatory reactions around hylan gel particles have also been histologically observed in synovial biopsies18,19. These reports make it especially important to consider safety differences among IA-HA products, and alternate ways of producing high molecular weight hyaluronan for viscosupplementation.