Hostname: page-component-848d4c4894-ttngx Total loading time: 0 Render date: 2024-05-19T18:41:29.984Z Has data issue: false hasContentIssue false
  • English
  • Français

Prospective Comparison of Tuberculin Skin Test and QuantiFERON-TB Gold In-Tube Assay for the Detection of Latent Tuberculosis Infection among Healthcare Workers in a Low-Incidence Setting

Published online by Cambridge University Press:  02 January 2015

Kristin J. Cummings ,
Tamara S. Smith ,
Elizabeth S. Shogren ,
Rashida Khakoo ,
Sharmilarani Nanda ,
Lana Bunner ,
Ann Smithmyer ,
Darlene Soccorsi ,
Michael L. Kashon  and
Gerald H. Mazurek
...Show all authors
Kristin J. Cummings*
Affiliation:
Division of Respiratory Disease Studies, Morgantown, West Virginia
Tamara S. Smith
Affiliation:
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, the Section of Allergy and Immunology, Department of Pediatrics, Morgantown, West Virginia
Elizabeth S. Shogren
Affiliation:
Division of Respiratory Disease Studies, Morgantown, West Virginia
Rashida Khakoo
Affiliation:
Section of Infectious Diseases, Department of Medicine, Morgantown, West Virginia
Sharmilarani Nanda
Affiliation:
Department of Pediatrics, Morgantown, West Virginia
Lana Bunner
Affiliation:
West Virginia University School of Medicine, the University Health Associates, West Virginia University, Morgantown, West Virginia
Ann Smithmyer
Affiliation:
Employee Health Department, West Virginia University Hospitals, Morgantown, West Virginia
Darlene Soccorsi
Affiliation:
Employee Health Department, West Virginia University Hospitals, Morgantown, West Virginia
Michael L. Kashon
Affiliation:
Health Effects Laboratory Division, Morgantown, West Virginia
Gerald H. Mazurek
Affiliation:
Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia
Lloyd N. Friedman
Affiliation:
Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut
David N. Weissman
Affiliation:
Division of Respiratory Disease Studies, Morgantown, West Virginia
*
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, MS-2800, Morgantown, WV 26505 (cvx5@cdc.gov)
Get access Rights & Permissions [Opens in a new window]

Abstract

We compared the results of the tuberculin skin test with the results of the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay among 182 low-risk healthcare workers. Overall agreement and specificity were high, but the tests did not agree on positive results. Only 2 of 5 positive QFT-GIT assay results could be confirmed with repeat analyses. Indeterminate results were associated with potential immunosuppression.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 30 , Issue 11 , November 2009 , pp. 1123 - 1126
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Institute of Medicine (US). Committee on the Elimination of Tuberculosis in the United States. In: Geiter, L, ed. Ending neglect: the elimination of tuberculosis in the United States. Washington, DC: National Academy Press; 2000.Google Scholar
2.Pai, M, Dheda, K, Cunningham, J, Scano, F, O'Brien, R. T-cell assays for the diagnosis of latent tuberculosis infection: moving the research agenda forward. Lancet Infect Dis 2007;7:428–438.Google Scholar
3.National Health Service (NHS). National Institute for Health and Clinical Excellence. Tuberculosis: clinical diagnosis and management of tuberculosis, and measures for its prevention and control. Clinical guideline 33. Developed by the National Collaborating Centre for Chronic Conditions. March 2006. Available at: http://www.nice.org.uk/page.aspx?o=CG033NICEguideline. Accessed May 7, 2009.Google Scholar
4.Targeted tuberculin testing and treatment of latent tuberculosis infection. Am J Respir Crit Care Med 2000;161(4 Pt 2):S221–S247.CrossRefGoogle Scholar
5.Mazurek, GH, Zajdowicz, MJ, Hankinson, AL, et al.Detection of Mycobacterium tuberculosis infection in United States Navy recruits using the tuberculin skin test or whole-blood interferon-γ release assays. Clin Infect Dis 2007;45:826–836.CrossRefGoogle ScholarPubMed
6.Menzies, D, Pai, M, Comstock, G. Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research. Ann Intern Med 2007;146:340–354.CrossRefGoogle ScholarPubMed
7.Pai, M, Riley, LW, Colford, JM Jr. Interferon-γ assays in the immunodiagnosis of tuberculosis: a systematic review. Lancet Infect Dis 2004;4:761–776.CrossRefGoogle ScholarPubMed
8.Pollock, NR, Campos-Neto, A, Kashino, S, et al.Discordant QuantiFERONTB Gold test results among US healthcare workers with increased risk of latent tuberculosis infection: a problem or solution? Infect Control Hosp Epidemiol 2008;29:878–886.Google Scholar
9.Veerapathran, A, Joshi, R, Goswami, K, et al.T-cell assays for tuberculosis infection: deriving cut-offs for conversions using reproducibility data. PLoS ONE 2008;3:e1850.Google Scholar
10.Leyten, EM, Prins, C, Bossink, AW, et al.Effect of tuberculin skin testing on a Mycobacterium tuberculosis–specific interferon-γ assay. Eur Respir J 2007;29:1212–1216.CrossRefGoogle ScholarPubMed