Hostname: page-component-76fb5796d-2lccl Total loading time: 0 Render date: 2024-04-27T01:05:07.027Z Has data issue: false hasContentIssue false
  • English
  • Français

Reduction in Inddence of Nosocomial Methicillin-Resistant Staphylococcus aureus (MRSA) Infection in an Intensive Care Unit: Role of Treatment With Mupirocin Ointment and Chlorhexidine Baths for Nasal Carriers of MRSA

Published online by Cambridge University Press:  21 June 2016

Ana Maria Sandri ,
Micheline Gisele Dalarosa ,
Luciana Ruschel de Alcântara ,
Laura da Silva Elias  and
Alexandre Prehn Zavascki
Ana Maria Sandri
Affiliation:
Infection Control Department, Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
Micheline Gisele Dalarosa
Affiliation:
Infection Control Department, Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
Luciana Ruschel de Alcântara
Affiliation:
Infection Control Department, Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
Laura da Silva Elias
Affiliation:
Infection Control Department, Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
Alexandre Prehn Zavascki*
Affiliation:
Infectious Diseases Unit, Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
*
Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul, Serviço de Infectologia, 6690 Ipiranga Avenue, Porto Alegre, RS 90610-000, Brazil (apzavascki@terra.com.br)
Get access Rights & Permissions [Opens in a new window]

Abstract

After the introduction of routine treatment for every nasal carrier of methicillin-resistant Staphylococcus aureus, active follow-up surveillance for nosocomial methicillin-resistant S. aureus infection was conducted for 5 years in an intensive care unit of a tertiary-care teaching hospital. There was a significant decrease in the incidence of nosocomial methicillin-resistant S. aureus infection during the later years of follow-up. Decolonization of nasal carriers of methicillin-resistant S. aureus is probably associated with such findings.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 27 , Issue 2 , February 2006 , pp. 185 - 187
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Pujol, M, Pena, C, Pallares, R, et al. Nosocomial Staphylococcus aureus bacteremia among nasal carriers of methicillin-resistant and methicillin-susceptible strains. Am J Med 1996; 100:509–516.CrossRefGoogle ScholarPubMed
2.von Eiff, C, Becker, K, Machka, K, Stammer, H, Peters, G. Nasal carriage as a source of Staphylococcus aureus bacteremia. N Engl J Med 2001; 344: 11–16.CrossRefGoogle ScholarPubMed
3.Corbella, X, Dominguez, MA, Pujol, M, et al. Staphylococcus aureus nasal carriage as a marker for subsequent staphylococcal infections in intensive care unit patients. Eur J Clin Microbiol Infect Dis 1997; 16:351–357.CrossRefGoogle ScholarPubMed
4.Kluytmans, JA, Mouton, JW, VandenBergh, MF, et al. Reduction of surgical-site infections in cardiothoracic surgery by elimination of nasal carriage of Staphylococcus aureus. Infect Control Hosp Epidemiol 1996; 17:780–785.CrossRefGoogle ScholarPubMed
5.Boelaert, JR, Van Landuyt, HW, Gordts, BZ, De Baere, YA, Messer, SA, Herwaldt, LA. Nasal and cutaneous carriage of Staphylococcus aureus in hemodialysis patients: the effect of nasal mupirocin. Infect Control Hosp Epidemiol 1996; 17:809–811.CrossRefGoogle Scholar
6.Garner, JS, Jarvis, WR, Emori, TG, Horan, TC, Hughes, JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988; 16:128–140.CrossRefGoogle ScholarPubMed
7.NCCLS. Performance standards for antimicrobial disk susceptibility test. NCCLS document M2-A7. Wayne, PA: NCCLS, 2000.Google Scholar
8.Kalmeijer, MD, Coertjens, H, van Nieuwland-Bollen, PM, et al. Surgical site infections in orthopedic surgery: the effect of mupirocin nasal ointment in a double-blind, randomized, placebo-controlled study. Clin Infect Dis 2002; 35:353–358.CrossRefGoogle Scholar
9.Wertheim, HF, Vos, MC, Ott, A, et al. Mupirocin prophylaxis against nosocomial Staphylococcus aureus infections in nonsurgical patients: a randomized study. Ann Intern Med 2004; 140:419–425.CrossRefGoogle ScholarPubMed