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Risk of Transmission and Features of Hepatitis C After Needlestick Injuries

Published online by Cambridge University Press:  02 January 2015

Saeed S. Hamid ,
Badar Farooqui ,
Qudsia Rizvi ,
Tarranum Sultana  and
Anwar A. Siddiqui
Saeed S. Hamid*
Affiliation:
Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan
Badar Farooqui
Affiliation:
Department of Microbiology, The Aga Khan University Hospital, Karachi, Pakistan
Qudsia Rizvi
Affiliation:
Department of Microbiology, The Aga Khan University Hospital, Karachi, Pakistan
Tarranum Sultana
Affiliation:
Department of Biochemistry, The Aga Khan University Hospital, Karachi, Pakistan
Anwar A. Siddiqui
Affiliation:
Department of Biochemistry, The Aga Khan University Hospital, Karachi, Pakistan
*
Department of Medicine, The Aga Khan University Hospital, PO Box 3500, Karachi 74800, Pakistan
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Abstract

The rate of transmission and management of needlestick injuries from hepatitis C virus (HCV) patients to healthcare workers is still a matter of debate. We used a stringent protocol using monthly transaminase levels and polymerase chain reaction for HCV RNA to monitor 53 healthcare workers prospectively for up to 6 months following needle injuries from HCV-positive patients. Evidence of transmission of HCV was found in only 2 workers (4%) with mild asymptomatic infection, one of which resolved spontaneously. Based on our experience, we now use a less-intensive follow-up protocol. Further investigation is required to determine the most cost-effective method to monitor individuals who suffer a needlestick injury from an HCV-positive patient.

Type
Concise Communications
Information
Infection Control & Hospital Epidemiology , Volume 20 , Issue 1 , January 1999 , pp. 63 - 64
Copyright
Copyright © The Society for Healthcare Epidemiology of America 1999

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References

1. Alter, MJ. Epidemiology of hepatitis C in the west. Semin Liver Dis 1995;15:5–14.Google Scholar
2. Hernandez, ME, Bruguera, M, Puyuelo, T, Barrera, JM, Sanchez Tapias, JM, Rodes, J. Risk of needle-stick injuries in the transmission of hepatitis C virus in hospital personnel. J Hepatol 1992;16:56–58.Google Scholar
3. Zuckerman, J, Clewley, G, Griffiths, P. Cockcroft, A. Prevalence of hepatitis C antibodies in clinical health care workers. Lancet 1994;343:1618–1620.Google Scholar
4. Petrosilla, N, Puro, V, Ippolito, G, Italian Study Group on blood borne occupational risk in dialysis. Prevalence of hepatitis C antibodies in health care workers. Lancet 1994;344:339–340.Google Scholar
5. Lanphear, BP, Linnermann, CC, Cannon, CG, Deronde, MM, Pendy, L, Kerley, LM. Hepatitis C virus infection in health care workers: risk of exposure and infection. Infect Control Hosp Epidemiol 1994;15:745–750.Google Scholar
6. Mitsui, T, Iwano, K, Masuko, K, Yamazaki, C, Okamoto, H, Tsuda, F, et al. Hepatitis C virus infection in medical personnel after needlestick accident. Hepatology 1992;16:1109–1114.CrossRefGoogle ScholarPubMed
7. Chomczynski, P, Sacchi, N. Single step method of RNA isolation by acid guanidium thiocynate-phenol-chloroform extraction. Ann Biochem 1987;162:156–159.Google Scholar
8. Shikata, T, Karasawa, T, Abe, K, Uzawa, T, Suzuki, H, Oda, T, et al. Hepatitis B e antigen and infectivity of hepatitis B virus. J Infect Dis 1977;136:571–576.Google Scholar
9. Royce, RA Sena, A, Cates, W, Cohen, MS. Sexual transmission of HIV. N Engl J Med 1997;336:1072–1078.Google Scholar
10. Alter, MJ, Margolis, HS, Krawczynski, K, Judson, FN, Mares, A, Alexander, WJ, et al. The natural history of community acquired hepatitis C in the United States. N Engl J Med 1992;327:1899–1905.Google Scholar
11. Zafar, AB, Butler, C, Podgorny, JM, Mennona, PA, Gaydos, LA, Sandiford, JA. Effect of a comprehensive program to reduce needlestick injuries. Infect Control Hosp Epidemiol 1997;18:712–715.Google Scholar