Low-density-lipoprotein subclasses and response to a low-fat diet in healthy men

doi:10.1093/ajcn/62.2.478S

The American Journal of Clinical Nutrition

Volume 62, Issue 2, August 1995, Pages 478S-487S

https://doi.org/10.1093/ajcn/62.2.478S Get rights and content

ABSTRACT

Lipid and lipoprotein responses to reduced dietary fat intake were investigated in relation to differences in distribution of low-density-lipoprotein (LDL) subclasses among 105 healthy men consuming high-fat (46% fat) and low-fat (24% fat) diets in random order for 6 wk each. With high-fat diets, 87 subjects had predominantly large, buoyant LDL (pattern A), whereas the remainder had primarily smaller, denser LDL (pattern B). With low-fat diets, 36 men changed from pattern A to B. Compared with the 51 men with pattern A with both diets (stable A group), men in the stable B group (n = 18) had significantly greater reductions in plasma LDL cholesterol, apolipoprotein B, and mass of mid-sized (LDL II) and small (LDL III) LDL subfractions. In both the stable A and change groups, there was a shift in LDL particle mass from larger, lipid-enriched (LDL I and II) to smaller, lipid-depleted (LDL III and IV) subfractions, suggestive of change in LDL composition with minimal change in particle number, and consistent with the observation of reduced plasma LDL cholesterol without reduced apolipoprotein B. Stable B subjects had significantly greater increases in the largest very-low-density-lipoprotein subfraction with the low-fat diet than the stable A group, and also had greater decreases in the high-density-lipoprotein (HDL) subclass HDL3 but smaller reductions in HDL2. Genetic and environmental factors influencing LDL subclass distributions thus may also contribute substantially to interindividual variation in plasma lipoprotein response to a low-fat diet.

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Low-density-lipoprotein subclasses and response to a low-fat diet in healthy men

ABSTRACT

J Lipid Res

Metabolism

Lancet

J Lipid Res

Comput Methods Programs Biomed

J Am Diet Assoc

J Am Diet Assoc

J Lipid Res

Lancet

Am J Med

J Lipid Res

Metabolism

Metabolism

Am Heart J

Metabolism

Atherosclerosis

Atherosclerosis

Metabolism

Lancet

Individual variation in the effects of dietary cholesterol on plasma lipoproteins and cellular homeostasis in man.

J Clin Invest

Variability in individual serum cholesterol response to change in diet.

Arteriosclerosis

Gene-diet interactions in lipoprotein metabolism.

Monogr Hum Genet

Attenuated hyper-cholestcrolemic response to a high-cholesterol diet in subjects heterozygous for the apolipoprotein A-IV-2 allele.

N Engl J Med

Xbal polymorphism of the apolipoprotein B gene influences plasma lipid response to diet intervention.

Clin Genet

Role of apolipoprotein E and B gene variation in determining response of lipid, lipoprotein, and apolipoprotein levels to increased dietary cholesterol.

Am J Hum Genet

Low-density lipoprotein subclass patterns and lipoprotein response to a reduced-fat diet in men.

FASEB J

The NHLBI Twin Study: heritability of apolipoprotein A-I, B, and low density lipoprotein subclasses and concordance for lipoprotein(a).

Atherosclerosis

Genetics of LDL subclass phenotypes in women twins: concordance, heritability, and commingling analysis.

Arterioscler Thromb

Genetic epidemiology of low-density lipoprotein subclass phenotypes.

Ann Med