Elsevier

Annals of Oncology

Volume 21, Issue 2, February 2010, Pages 232-237
Annals of Oncology

original articles
lung cancer
The strength of female sex as a prognostic factor in small-cell lung cancer: a pooled analysis of chemotherapy trials from the Manchester Lung Group and Medical Research Council Clinical Trials Unit

https://doi.org/10.1093/annonc/mdp300Get rights and content
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Abstract

Background

Previous studies reported that women survive longer than men, but experience greater toxicity, when treated for small-cell lung cancer (SCLC).

Methods

Individual patient data from six randomized phase II/III chemotherapy trials, from the Manchester Lung Group and UK Medical Research Council, were pooled for analysis. End points included overall survival, response rate, toxicity, dose intensity (DI) and transfusion rates.

Results

Of 1707 patients analyzed, 44% were women. At baseline, women had poorer performance status (PS) (57% versus 67% Eastern Cooperative Oncology Group PS 0–1/Karnofsky PS 80–100, P = 0.0004) and more were of normal weight or underweight (57% versus 48%, P = 0.003), but fewer were anemic (25% versus 62%, P < 0.0001). Response rates between women and men were similar (77% versus 76%, P = 0.64). In univariate [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.76–0.96, P = 0.006] and multivariate (HR 0.88, 95% CI 0.79–0.99, P = 0.04) analyses, female sex predicted for longer survival. Women experienced more grade 3/4 emesis (18% versus 9%, P < 0.0001) and grade 3/4 mucositis (13% versus 8%, P = 0.005) than men. There were no differences in DI, infections, transfusions or treatment-related deaths.

Conclusion

Data from >1700 patients in randomized SCLC chemotherapy trials confirm that women survive modestly longer than men but may experience greater toxicity.

Keywords

chemotherapy
sex
small-cell lung cancer

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