Elsevier

Annals of Oncology

Volume 24, Issue 6, June 2013, Pages 1667-1674
Annals of Oncology

original articles
epidemiology
A comparison of trends in mortality from primary liver cancer and intrahepatic cholangiocarcinoma in Europe

https://doi.org/10.1093/annonc/mds652Get rights and content
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Abstract

Background

To update and compare mortality from primary liver cancer (PLC) and intrahepatic cholangiocarcinoma (ICC) in Europe in 1990–2010.

Materials and methods

We used data from the World Health Organization (WHO) to compute age-standardized (world population) mortality rates, and used joinpoint analysis to identify substantial changes.

Results

Between 2002 and 2007, PLC rates in the European Union (EU) declined from 3.9 to 3.6/100 000 men. Around 2007, the highest male rates were in France (6.2/100 000), Spain (4.9), and Italy (4.0), while the lowest ones were in Sweden (1.1), the Netherlands (1.2), and the UK (1.8). In women, mortality was lower (0.8/100 000 in 2007 in the EU), and showed more favourable trends, with a decline of over 2% per year over the last two decades as compared with 0.4% in men, in the EU. In contrast, the EU mortality from ICC increased by around 9% in both sexes from 1990 to 2008, reaching rates of 1.1/100 000 men and 0.75/100 000 women. The highest rates were in UK, Germany, and France (1.2–1.5/100 000 men, 0.8–1.1/100 000 women).

Conclusions

PLC mortality has become more uniform across Europe over recent years, with an overall decline; in contrast, ICC mortality has substantially increased in most Europe.

Keywords

cancer
cholangiocarcinoma
hepatocellular carcinoma
intrahepatic
liver
mortality

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