Case ReportsCase Report: I reatment of Blastomycosis with Fluconazole
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Cited by (21)
First Japanese case of disseminated blastomycosis imported from North America: A case report
2023, Journal of Infection and ChemotherapyBlastomycosis
2016, Infectious Disease Clinics of North AmericaCitation Excerpt :Itraconazole has excellent in vitro activity against B dermatitidis, but the CSF levels are very poor. Fluconazole, on the other hand, is not recommended for the treatment of blastomycosis but has excellent penetration into the CSF and has proved effective in treating CNS blastomycosis in a few patients.70 Voriconazole achieves good CSF concentrations and also has excellent activity against the organism.
Blastomycosis: New Insights into Diagnosis, Prevention, and Treatment
2009, Clinics in Chest MedicineCitation Excerpt :Following initial therapy with amphotericin B, the choice of an oral agent for further therapy is unclear. Itraconazole has poor CNS penetration152 and although fluconazole crosses the blood–brain barrier effectively, clinical failures have been described.131,132,153,154 Voriconazole achieves good penetration into the CNS147 and there have been several reports of successful therapy when used to treat CNS blastomycosis.127,148,149
Treatment and experimental therapeutics of blastomycosis
1995, International Journal of Antimicrobial AgentsIndications for the surgical management of central nervous system blastomycosis
1995, Surgical NeurologyBlastomycosis
2020, Seminars in Respiratory and Critical Care Medicine