Journal of the American Academy of Child & Adolescent Psychiatry
ARTICLEPlasma Cortisol and Aggression in Boys With ADHD
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Cited by (76)
An exploratory analysis of testosterone, cortisol, and aggressive behavior type in men and women
2021, Biological PsychologyCitation Excerpt :The majority of evidence indicates a negative association between cortisol and aggressive or antisocial behavior (van Goozen, Fairchild, Snoek, & Harold, 2007). However, there are null findings and significant results that are opposite general trends (Gerra et al., 1997; Kruesi, Schmidt, Donnelly, Hibbs, & Hamburger, 1989; McBurnett et al., 2005; Schulz, Halperin, Newcorn, Sharma, & Gabriel, 1997; van Bokhoven et al., 2005). Mixed results and weak associations across studies relating cortisol and testosterone individually to aggression may be explained by the interactive effects of these hormones on aggressive behaviors.
The hyporeactivity of salivary cortisol at stress test (TSST-C) in children with internalizing or externalizing disorders is contrastively associated with α-amylase
2015, Journal of Psychiatric ResearchCitation Excerpt :In the sub-groups of externalizing disorders, low basal cortisol was reported in disruptive behaviors (McBurnett et al., 2000), ODD (Pajer et al., 2001; van Goozen et al., 1998), conduct disorders (Vanyukov et al., 1993), and comorbid ODD and attention deficit/hyperactivity disorders (Karyawasam et al., 2003). However, not all studies could reproduce these findings (Fairchild et al., 2008; Schulz et al., 1997). During a stress test, a blunted cortisol response appears to be a robust finding in the literature (Alink et al., 2008; Fairchild et al., 2008; Hartman et al., 2013; van Goozen et al., 1998).
Chronic systemic administration of serotonergic ligands flibanserin and 8-OH-DPAT enhance HPA axis responses to restraint in female marmosets
2013, PsychoneuroendocrinologyCitation Excerpt :While exposure to a stressful environment is associated with impaired sexual behavior and elevated aggression in female rats (Yoon et al., 2005), and personal distress and distress in partner relations are hallmarks of HSDD in women (DSM-IV-TR, 2000), the link between HPA axis activity and aggression is not clear. In some human studies high aggression is associated with low HPA axis activity (Gordis et al., 2006), but others do not confirm such an inverse relationship between aggression and stress hormone levels (Schulz et al., 1997). It is therefore not clear whether the behavioral associations with increased HPA responsiveness to restraint in the current study reflect HPA axis hormone-mediated changes in behavior, or whether both behavior and HPA hormones serve as separate and reliable biomarkers of 8-OH-DPAT-mediated action.
Cortisol levels in children with Attention-Deficit/Hyperactivity Disorder
2012, Journal of Psychiatric ResearchAltered circadian profiles in attention-deficit/hyperactivity disorder: An integrative review and theoretical framework for future studies
2012, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Some authors confirmed a hypo-arousal pattern in children with ADHD with ODD measuring both awakening (Freitag et al., 2009) and basal values (Kariyawasam et al., 2002) while other authors failed to find any robust association between waking levels and comorbid problems in ADHD (Hastings et al., 2009). In line with these findings, no differences in basal levels between ADHD children with aggression and without aggression have been reported (Schulz et al., 1997), suggesting the possibility that certain characteristics of ADHD, rather than aggression, could be associated with cortisol levels. Very recently, this complex relation between ADHD/ODD comorbidity and diurnal cortisol profiles has become a focus of interest.
This research was supported by NIMH grant 1 R01 MH46448, The William T. Grant foundation's Faculty Scholar's Award Program, and grant 5 M01 RR00071 to the Mount Sinai General Clinical Research Center from the National Center for Research Resources, NIH. Special thanks to Debbie Lazarus for technical support.